CDK5:p25 phosphorylates PRDX1

Stable Identifier
R-HSA-8868567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CDK5:p25 phosphorylates PRDX1
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Oxidative stress, manifested through accumulation of reactive oxygen species in the cell, is one of the hallmarks of Alzheimer's disease. Based on mouse model studies, CDK5, aberrantly activated by binding to p25, phosphorylates the peroxide reductase PRDX1 on a conserved threonine residue T90, thus inactivating it and contributing to ROS accumulation (Sun et al. 2008).

Literature References
PubMed ID Title Journal Year
18691386 Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

Sun, KH, Vincent, F, Shah, K, de Pablo, Y

J. Neurochem. 2008
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of CDK5:p25 [cytosol]

Physical Entity
CDK5:p25 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Cdk5:p25 phosphorylates Prdx1 (Mus musculus)
Disease
Name Identifier Synonyms
Alzheimer's disease DOID:10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-04-22)
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