Reactome | SYNJ hydrolyze PI(4,5)P2 to PI(4)P

SYNJ hydrolyze PI(4,5)P2 to PI(4)P

Stable Identifier

R-HSA-8868648

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Inositol-5-phosphatases like SYNJs and OCRL hydrolyze PI(4,5)P2 to PI(4)P. In the context of CME, this promotes the abortive turnover (disassembly) of some CCPs, contributes to the dynamin-mediated scission of the clathrin-coated vesicle neck, and promotes clathrin uncoating following scission (Guan et al, 2010; Cremona et al, 1999; Mani et al, 2007; Chang-Ileto et al, 2011; Antonescu et al, 2011; reviewed in McMahon and Boucrot, 2011; Daumke et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
18093523	The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals Ryan, TA, Cremona, O, Di Paolo, G, Mani, M, Lucast, L, De Camilli, P, Lee, SY	Neuron	2007
21779028	Molecular mechanism and physiological functions of clathrin-mediated endocytosis Boucrot, E, McMahon, HT	Nat. Rev. Mol. Cell Biol.	2011
21613550	Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size Aguet, F, Antonescu, CN, Danuser, G, Schmid, SL	Mol. Biol. Cell	2011
20826345	Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding Kirchhausen, T, Han, D, Guan, R, Harrison, SC, Dai, H	Structure	2010
24581490	BAR domain scaffolds in dynamin-mediated membrane fission Daumke, O, Haucke, V, Roux, A	Cell	2014
10535736	Essential role of phosphoinositide metabolism in synaptic vesicle recycling Flavell, RA, Cremona, O, Takei, K, Wenk, MR, Nemoto, Y, McCormick, DA, Di Paolo, G, Daniell, L, Lüthi, A, De Camilli, P, Shears, SB, Kim, WT	Cell	1999

Participants

Input

Output

Participates

as an event of

Clathrin-mediated endocytosis (Homo sapiens)

Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane]

Physical Entity

PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)

Activity

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (GO:0004439)

Orthologous Events

SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Bos taurus)

SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)

SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)

SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)

SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Gallus gallus)

SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Mus musculus)

SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)