misfolded CFTR [endoplasmic reticulum membrane]

Stable Identifier
R-HSA-8868730
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Cystic fibrosis transmembrane conductance regulator, CFTR_HUMAN
misfolded CFTR [endoplasmic reticulum membrane] icon
Locations in the PathwayBrowser for interactor UniProt:Q01518 CAP1
External Reference Information
External Reference
Gene Names
CFTR, ABCC7
Chain
chain:1-1480
Reference Transcript
Other Identifiers
1080
11722757_at
17050694
17050697
17050733
205043_PM_at
205043_at
215702_PM_s_at
215702_s_at
215703_PM_at
215703_at
217026_PM_at
217026_at
234702_PM_x_at
234702_x_at
3020624
3020625
3020627
3020647
3020648
3020649
3020652
3020654
3020656
3020658
3020659
3020661
3020662
3020663
3020664
3020666
3020667
3020668
3020670
3020672
3020673
3020674
3020679
3020680
3020682
3020683
3020684
3020685
3020686
3020688
3020689
3020694
3020695
3020696
3020698
3020699
3020701
3020702
3020705
3020706
3020707
3020708
3020709
3020712
3020717
3020718
3020719
3020721
3020722
3020723
3020724
3020725
3020726
3020727
3020729
31578_at
36816_s_at
36817_at
3902164
3902300
77392_at
8135661
AC000061_cds2_at
AC000061_cds3_at
A_14_P104877
A_14_P114787
A_14_P115109
A_14_P129538
A_14_P132049
A_23_P215720
A_24_P931355
GE571878
GE62403
GO:0000166
GO:0003824
GO:0005215
GO:0005254
GO:0005260
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005765
GO:0005768
GO:0005769
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006629
GO:0006695
GO:0006811
GO:0006821
GO:0006904
GO:0009986
GO:0010008
GO:0015106
GO:0015108
GO:0015701
GO:0016020
GO:0016324
GO:0016787
GO:0016853
GO:0016887
GO:0017081
GO:0019869
GO:0019899
GO:0022414
GO:0030165
GO:0030301
GO:0030660
GO:0030669
GO:0031410
GO:0031901
GO:0032991
GO:0034220
GO:0034707
GO:0034976
GO:0035377
GO:0035774
GO:0042626
GO:0043225
GO:0043226
GO:0045921
GO:0048240
GO:0050891
GO:0051087
GO:0051454
GO:0051649
GO:0055037
GO:0055038
GO:0055085
GO:0060081
GO:0070175
GO:0071320
GO:0071889
GO:0097186
GO:0098772
GO:0106138
GO:0140359
GO:0140657
GO:1902161
GO:1902476
GO:1902943
GO:1904322
HMNXSV003020096
HMNXSV003030732
HMNXSV003037881
Hs.283899.0.S1_3p_at
Hs.326797.0.S1_3p_at
Hs.663.1.A1_3p_a_at
ILMN_1705813
M55131_at
PH_hs_0024884
PH_hs_0026496
TC07000725.hg
TC07000726.hg
TC07000727.hg
TC07002542.hg
g6995995_3p_at
p15442
Participates
Other forms of this molecule
Inferred To
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
707
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
IntEnz
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (989)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O14745 NHRF1      0.938 26
 UniProt:Q15599 NHRF2      0.93 28
 UniProt:P30153 PPP2R1A  2 0.889 24
 UniProt:P27824 CANX  2 0.888 27
 UniProt:O00299 CLIC1      0.788 15
 UniProt:Q9Y678 COPG1  4 0.788 21
 UniProt:P10809 HSPD1  6 0.788 24
 UniProt:Q9UN37 VPS4A  1 0.788 9
 UniProt:P06702 S100A9  3 0.774 15
 UniProt:Q14974 KPNB1  5 0.774 24
 UniProt:P11021 HSPA5  6 0.774 25
 UniProt:P31689 DNAJA1  2 0.774 27
 UniProt:P02545 LMNA  3 0.774 23
 UniProt:P13569 CFTR  17 0.77 14
 UniProt:Q9HD26 GOPC  3 0.767 10
 UniProt:P26599 PTBP1  1 0.749 13
 UniProt:P15311 EZR  3 0.745 22
 UniProt:P60981 DEST      0.738 16
 UniProt:P31040 SDHA  2 0.738 15
 UniProt:P13667 PDIA4      0.736 18
 UniProt:Q9P035 HACD3  1 0.736 15
 UniProt:P60709 ACTB  5 0.731 6
 UniProt:Q01518 CAP1  3 0.725 14
 UniProt:P62879 GNB2  4 0.725 12
 UniProt:P28799 GRN  2 0.725 19
 UniProt:O95793 STAU1      0.725 13
 UniProt:P62158 CALM      0.725 18
 UniProt:Q15370 ELOB  2 0.725 18
 UniProt:P47756 CAPZB  1 0.725 23
 UniProt:Q15369 ELOC  2 0.725 12
 UniProt:P30101 PDIA3  3 0.725 12
 UniProt:Q99942 RNF5  1 0.718 8
 UniProt:Q92734 TFG  7 0.707 7
 UniProt:O14545 TRAD1      0.707 9
 UniProt:Q96CS3 FAF2  3 0.706 17
 UniProt:P61619 SEC61A1  2 0.706 15
 UniProt:P62910 RPL32  1 0.706 14
 UniProt:P04843 RPN1  1 0.706 22
 UniProt:P50991 CCT4  1 0.706 17
 UniProt:Q9UHB6 LIMA1      0.706 22
 UniProt:P16615 ATP2A2  2 0.706 16
 UniProt:P07910 HNRNPC  3 0.706 18
 UniProt:P04899 GNAI2  1 0.706 13
 UniProt:P05783 KRT18  1 0.706 21
 UniProt:P53618 COPB1  8 0.706 13
 UniProt:P63104 YWHAZ  2 0.706 22
 UniProt:P61160 ACTR2  4 0.706 15
 UniProt:P61163 ACTR1A  1 0.706 11
 UniProt:O95433 AHSA1      0.706 13
 UniProt:O95425 SVIL      0.706 14
 UniProt:Q8WWI1 LMO7  3 0.706 17
 UniProt:P30041 PRDX6  3 0.706 17
 UniProt:A0FGR8 ESYT2  1 0.706 15
 UniProt:Q9NYL9 TMOD3  1 0.706 21
 UniProt:Q13045 FLII      0.706 18
 UniProt:Q9Y608 LRRF2      0.706 14
 UniProt:P17812 CTPS1  1 0.706 20
 UniProt:P56192 MARS1  1 0.706 18
 UniProt:P50402 EMD  4 0.706 15
 UniProt:P55072 VCP  8 0.706 21
 UniProt:P13010 XRCC5  4 0.706 21
 UniProt:Q5T4S7 UBR4  5 0.706 15
 UniProt:O60884 DNAJA2  1 0.706 17
 UniProt:P17655 CAPN2  2 0.706 17
 UniProt:Q9UL46 PSME2  2 0.706 13
 UniProt:P57088 TMM33      0.706 21
 UniProt:Q9BUF5 TUBB6  6 0.706 20
 UniProt:P04075 ALDOA  6 0.706 18
 UniProt:Q12904 AIMP1  1 0.706 16
 UniProt:O75340 PDCD6      0.706 8
 UniProt:P46779 RPL28  1 0.706 22
 UniProt:P37802 TAGLN2  2 0.706 20
 UniProt:P32119 PRDX2  2 0.706 22
 UniProt:Q14257 RCN2      0.706 18
 UniProt:P04792 HSBP1  3 0.706 21
 UniProt:O43852 CALU  3 0.706 13
 UniProt:P47897 QARS1  2 0.706 18
 UniProt:P63244 RACK1  1 0.706 19
 UniProt:P00338 LDHA  2 0.706 20
 UniProt:P35579 MYH9  3 0.706 21
 UniProt:O14980 XPO1  2 0.706 24
 UniProt:P49023 PXN  4 0.706 12
 UniProt:P38646 HSPA9  6 0.706 23
 UniProt:P35232 PHB  2 0.706 17
 UniProt:Q13200 PSMD2  5 0.706 17
 UniProt:P04637 TP53  20 0.706 18
 UniProt:Q06830 PRDX1  3 0.706 21
 UniProt:P50454 SERPINH1  1 0.706 23
 UniProt:P06733 ENO1  1 0.706 21
 UniProt:P78527 PRKDC  4 0.706 20
 UniProt:P22061 PCMT1  1 0.706 19
 UniProt:P20700 LMNB1  8 0.706 21
 UniProt:Q5T2W1 NHRF3      0.702 6
 UniProt:Q9BUN8 DERL1  1 0.695 8
 UniProt:Q6PID8 KLD10      0.677 9
 UniProt:P05787 KRT8  1 0.677 11
 UniProt:P19474 TRIM21  1 0.677 24
 UniProt:Q14694 USP10  3 0.665 7
 UniProt:Q14192 FHL2  1 0.659 10
 UniProt:Q9QX74 SHAN2      0.658 3
 UniProt:P07237 P4HB  3 0.658 17
 UniProt:Q9H8Y8 GORASP2  2 0.646 6
 UniProt:P04632 CAPNS1  2 0.643 5
 UniProt:P08107 HSP71      0.643 5
 UniProt:P31151 S100A7  2 0.643 10
 UniProt:Q9NQH7 XPP3      0.643 8
 UniProt:P62841 RPS15  2 0.643 11
 UniProt:Q9Y3U8 RPL36  1 0.643 11
 UniProt:P05109 S100A8  3 0.643 11
 UniProt:P56537 IF6      0.643 11
 UniProt:P13987 CD59  8 0.643 9
 UniProt:Q9P0L0 VAPA  4 0.64 13
 UniProt:O95292 VAPB  2 0.64 12
 UniProt:Q9Y295 DRG1  2 0.64 9
 UniProt:P09972 ALDOC  5 0.64 8
 UniProt:P45880 VDAC2  6 0.64 10
 UniProt:P13804 ETFA  1 0.64 7
 UniProt:P55036 PSMD4  1 0.64 13
 UniProt:Q96PK6 RBM14  1 0.64 13
 UniProt:Q8WWA1 TMM40      0.632 9
 UniProt:Q9NUU7 DD19A      0.618 9
 UniProt:Q9UEU0 VTI1B  2 0.618 10
 UniProt:P14868 DARS1  1 0.615 16
 UniProt:P14866 HNRNPL  1 0.615 12
 UniProt:Q16643 DBN1  1 0.615 20
 UniProt:P11586 MTHFD1  1 0.615 18
 UniProt:P14618 PKM  3 0.615 20
 UniProt:P48643 CCT5  1 0.615 14
 UniProt:P40926 MDH2  1 0.615 9
 UniProt:P35580 MYH10  1 0.615 21
 UniProt:Q13148 TADBP      0.615 9
 UniProt:P13797 PLST      0.615 9
 UniProt:Q14204 DYNC1H1  3 0.615 20
 UniProt:O94905 ERLIN2  3 0.615 10
 UniProt:P27708 CAD  1 0.615 19
 UniProt:Q14697 GANAB  1 0.615 17
 UniProt:P62917 RPL8  3 0.615 20
 UniProt:Q99829 CPNE1  2 0.615 13
 UniProt:P50990 CCT8  5 0.615 19
 UniProt:P11142 HSPA8  10 0.615 22
 UniProt:P48444 ARCN1  4 0.615 8
 UniProt:O43795 MYO1B      0.615 20
 UniProt:Q13310 PABP4      0.615 12
 UniProt:Q9P2E9 RRBP1  2 0.615 10
 UniProt:O75369 FLNB  1 0.615 21
 UniProt:P37108 SRP14  4 0.615 12
 UniProt:P22087 FBL  1 0.615 13
 UniProt:P17980 PSMC3  5 0.615 15
 UniProt:O43175 PHGDH  1 0.615 12
 UniProt:Q96PU5 NEDD4L  2 0.615 8
 UniProt:Q9Y305 ACOT9  1 0.615 14
 UniProt:Q69YQ0 CYTSA      0.615 16
 UniProt:O00425 IGF2BP3  1 0.615 10
 UniProt:O95831 AIFM1      0.615 11
 UniProt:O60762 DPM1  4 0.615 11
 UniProt:P49368 CCT3  1 0.615 10
 UniProt:P53621 COPA  4 0.615 16
 UniProt:P25398 RPS12  2 0.615 18
 UniProt:Q9UM54 MYO6  3 0.615 22
 UniProt:P29992 GNA11  1 0.615 6
 UniProt:O95817 BAG3  1 0.615 15
 UniProt:Q92614 MYO18A  4 0.615 15
 UniProt:O00232 PSMD12  5 0.615 15
 UniProt:Q6WCQ1 MPRIP  2 0.615 18
 UniProt:Q9BR76 COR1B      0.615 7
 UniProt:P27348 YWHAQ  1 0.615 15
 UniProt:P62258 YWHAE  1 0.615 18
 UniProt:P67936 TPM4  3 0.615 19
 UniProt:P61158 ACTR3  1 0.615 13
 UniProt:Q99497 PARK7  7 0.615 16
 UniProt:P06576 ATP5F1B  6 0.615 20
 UniProt:Q9ULV4 COR1C      0.615 16
 UniProt:P40227 CCT6A  1 0.615 9
 UniProt:O00264 PGRMC1  2 0.615 19
 UniProt:Q7Z406 MYH14  1 0.615 20
 UniProt:Q00610 CLTC  10 0.615 21
 UniProt:P84090 ERH      0.615 14
 UniProt:Q15084 PDIA6  3 0.615 16
 UniProt:Q08554 DSC1  3 0.615 5
 UniProt:Q9UJZ1 STOML2  1 0.615 13
 UniProt:Q5D862 FLG2  2 0.615 12
 UniProt:Q9UJW0 DCTN4  1 0.615 8
 UniProt:P22626 HNRNPA2B1  2 0.615 14
 UniProt:P12814 ACTN1  3 0.615 19
 UniProt:P18124 RPL7  1 0.615 20
 UniProt:Q9NZ01 TECR  1 0.615 18
 UniProt:Q15293 RCN1  2 0.615 13
 UniProt:P30048 PRDX3  1 0.615 14
 UniProt:Q9UBM7 DHCR7  1 0.615 8
 UniProt:Q8WWM7 ATX2L      0.615 5
 UniProt:P53396 ACLY  4 0.615 17
 UniProt:P55786 NPEPPS  1 0.615 17
 UniProt:Q9H3U1 UN45A      0.615 17
 UniProt:Q14152 EIF3A  1 0.615 11
 UniProt:Q9UBQ5 EIF3K  1 0.615 11
 UniProt:P50914 RPL14  1 0.615 18
 UniProt:Q15233 NONO      0.615 14
 UniProt:P62906 RPL10A  1 0.615 15
 UniProt:P47755 CAPZA2  2 0.615 15
 UniProt:P23526 AHCY  3 0.615 15
 UniProt:P25705 ATP5F1A  3 0.615 20
 UniProt:P34897 SHMT2  2 0.615 10
 UniProt:Q16543 CDC37  1 0.615 11
 UniProt:P31150 GDI1  1 0.615 7
 UniProt:P31153 MAT2A  1 0.615 14
 UniProt:P35998 PSMC2  5 0.615 16
 UniProt:Q03252 LMNB2      0.615 6
 UniProt:P62826 RAN  2 0.615 14
 UniProt:Q08J23 NSUN2  1 0.615 14
 UniProt:P55060 XPO2      0.615 15
 UniProt:Q13492 PICALM  3 0.615 8
 UniProt:P35241 RDX  2 0.615 10
 UniProt:P83731 RPL24  1 0.615 20
 UniProt:Q04760 GLO1  1 0.615 16
 UniProt:Q14318 FKBP8  2 0.615 11
 UniProt:P23246 SFPQ  3 0.615 14
 UniProt:P60660 MYL6  2 0.615 19
 UniProt:P58107 EPIPL      0.615 16
 UniProt:Q9UBX3 SLC25A10  1 0.615 13
 UniProt:O00571 DDX3X  3 0.615 14
 UniProt:P17858 PFKL  4 0.615 16
 UniProt:P49207 RPL34  1 0.615 18
 UniProt:O14974 PPP1R12A  4 0.615 13
 UniProt:Q96A65 EXOC4  2 0.615 6
 UniProt:Q8WUY1 THEM6      0.615 6
 UniProt:P07814 EPRS1  1 0.615 8
 UniProt:Q00325 S25A3      0.615 15
 UniProt:P61313 RPL15  1 0.615 16
 UniProt:P60228 EIF3E  1 0.615 10
 UniProt:P40616 ARL1  2 0.615 14
 UniProt:Q9UKM9 RALY      0.615 10
 UniProt:P06753 TPM3  3 0.615 14
 UniProt:Q02978 SLC25A11  1 0.615 17
 UniProt:Q96TA1 NIBA2      0.615 14
 UniProt:P31943 HNRNPH1  1 0.615 14
 UniProt:P31944 CASP14  2 0.615 10
 UniProt:Q10567 AP1B1  5 0.615 13
 UniProt:O94832 MYO1D      0.615 19
 UniProt:P61106 RAB14  7 0.615 12
 UniProt:Q96P70 IPO9      0.615 21
 UniProt:Q9UGI8 TES      0.615 12
 UniProt:P29401 TKT  1 0.615 9
 UniProt:P18669 PGAM1  4 0.615 12
 UniProt:O14579 COPE  4 0.615 11
 UniProt:O00165 HAX1      0.615 11
 UniProt:O95573 ACSL3  2 0.615 21
 UniProt:O00159 MYO1C  1 0.615 20
 UniProt:Q08209 PPP3CA  2 0.615 10
 UniProt:Q9H4M9 EHD1  1 0.615 14
 UniProt:Q96N67 DOCK7  1 0.615 13
 UniProt:P67809 YBX1  5 0.615 13
 UniProt:P05387 RPLP2  1 0.615 16
 UniProt:P05388 RPLP0  1 0.615 20
 UniProt:P08670 VIM  11 0.615 11
 UniProt:Q15181 PPA1  1 0.615 11
 UniProt:P04080 CSTB  4 0.615 12
 UniProt:P35606 COPB2  4 0.615 10
 UniProt:P18031 PTPN1  2 0.615 11
 UniProt:O15027 SEC16A  1 0.615 12
 UniProt:P46977 STT3A  1 0.615 12
 UniProt:P12956 XRCC6  5 0.615 13
 UniProt:rl10_rl10l_human EBI-25396130      0.615 8
 UniProt:P13807 GYS1  3 0.615 5
 UniProt:P56545 CTBP2  1 0.615 16
 UniProt:Q9NVI7 ATD3A      0.615 10
 UniProt:P53007 SLC25A1  1 0.615 8
 UniProt:P43686 PSMC4  2 0.615 21
 UniProt:Q15393 SF3B3  1 0.615 12
 UniProt:P78371 CCT2  3 0.615 17
 UniProt:P46778 RPL21  1 0.615 16
 UniProt:O95373 IPO7      0.615 13
 UniProt:O43707 ACTN4  3 0.615 19
 UniProt:Q9HAV7 GRPEL1  1 0.615 10
 UniProt:P46783 RPS10  2 0.615 14
 UniProt:Q15366 PCBP2  2 0.615 18
 UniProt:P07195 LDHB  1 0.615 14
 UniProt:Q13155 AIMP2  1 0.615 14
 UniProt:O75521 ECI2      0.615 18
 UniProt:P18085 ARF4  1 0.615 13
 UniProt:Q14498 RBM39  1 0.615 14
 UniProt:Q96IZ0 PAWR      0.615 15
 UniProt:Q14254 FLOT2  1 0.615 12
 UniProt:Q93008 USP9X  1 0.615 8
 UniProt:Q9Y2Z0 SUGT1  1 0.615 9
 UniProt:P07947 YES1  2 0.615 12
 UniProt:P17987 TCP1  1 0.615 13
 UniProt:P20339 RAB5A  7 0.615 10
 UniProt:P15924 DSP  4 0.615 18
 UniProt:P31948 STIP1  1 0.615 9
 UniProt:Q13813 SPTAN1  6 0.615 21
 UniProt:Q9UJU6 DBNL  7 0.615 11
 UniProt:P52272 HNRNPM  1 0.615 20
 UniProt:Q9Y230 RUVBL2  1 0.615 13
 UniProt:P62191 PSMC1  2 0.615 16
 UniProt:P63000 RAC1  6 0.615 12
 UniProt:Q5SRE5 NUP188