rRNA processing in the nucleus and cytosol

Stable Identifier
Homo sapiens
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Each eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 28S rRNA are produced by endonucleolytic and exonucleolytic processing of a single 47S precursor (pre-rRNA) (reviewed in Henras et al. 2015). Transcription of ribosomal RNA genes, processing of pre-rRNA, modification of nucleotide residues within the rRNA, and assembly of precursor 60S and 40S subunits occur predominantly in the nucleolus (reviewed in Hernandez-Verdun et al. 2010, Boschi-Muller and Motorin 2013), with a few late reactions occurring in the cytosol.

Literature References
PubMed ID Title Journal Year
24490730 Chemistry enters nucleic acids biology: enzymatic mechanisms of RNA modification

Motorin, Y, Boschi-Muller, S

Biochemistry Mosc. 2013
25346433 An overview of pre-ribosomal RNA processing in eukaryotes

O'Donohue, MF, Plisson-Chastang, C, Chakraborty, A, Henras, AK, Gleizes, PE

Wiley Interdiscip Rev RNA 2015
21956940 The nucleolus: structure/function relationship in RNA metabolism

Hernandez-Verdun, D, Thiry, M, Roussel, P, Sirri, V, Lafontaine, DL

Wiley Interdiscip Rev RNA 2010
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