Reactome | SYT2 [clathrin-coated endocytic vesicle membrane]

SYT2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869116

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Synaptotagmin 2

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N9I0 SYT2

Gene Names

SYT2

Chain

chain:1-419

Reference Genes

BioGPS Gene:127833 SYT2

COSMIC (genes):SYT2 SYT2

CTD Gene:127833 SYT2

dbSNP Gene:127833 SYT2

ENSEMBL:ENSG00000143858 SYT2

HGNC:11510 SYT2

KEGG:hsa:127833 SYT2

Monarch:127833 SYT2

NCBI Gene:127833 SYT2

OMIM:600104 SYT2

UCSC:Q8N9I0 SYT2

Reference Transcript

Other Identifiers

11729017_a_at

11755675_a_at

127833

16698038

214903_PM_at

214903_at

2451260

2451262

2451263

2451264

2451265

2451266

2451267

2451268

2451269

2451270

2451271

2451272

2451273

2451274

2451275

2451276

2451277

2451278

2451279

2451280

2451282

2451283

2451284

2451285

2451286

2451287

2451288

2451291

2451299

2451301

3587303

3615758

36251_at

7923442

A_23_P104098

A_33_P3214899

A_33_P3365755

GE54641

GO:0000149

GO:0001786

GO:0005509

GO:0005515

GO:0005544

GO:0005737

GO:0005886

GO:0008289

GO:0016020

GO:0016192

GO:0030154

GO:0030276

GO:0030424

GO:0030669

GO:0030672

GO:0031045

GO:0031410

GO:0042584

GO:0043226

GO:0043533

GO:0045202

GO:0046872

GO:0048488

GO:0048791

GO:0070382

GO:1903861

HMNXSV003016331

Hs.25422.0.S1_3p_at

ILMN_1770857

PH_hs_0002236

PH_hs_0026142

TC01003705.hg

Participates

as a component of

SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

SYT2 [plasma membrane]

SYT2 [synaptic vesicle membrane]

Inferred To

snt-5 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Homologues of SYT2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Homologues of SYT2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

SYT2 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

SYT2 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

SYT2 [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

SYT2 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

SYT2 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

SYT2 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

SYT2 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Sytalpha [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSG00000143858, ENSP00000356237, ENST00000367267, ENSP00000356236, ENST00000367268

OpenTargets

ENSG00000143858

GeneCards

SYT2

HPA

ENSG00000143858-SYT2

PRO

Q8N9I0

Pharos - Targets

Q8N9I0

GlyGen

Q8N9I0

Orphanet

SYT2

HMDB Protein

HMDBP08029

PDB

6G5G

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P21579 SYT1	7	SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372508) SYT1 [plasma membrane] (R-HSA-168786) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917741) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372514) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-210536) SYT1 [synaptic vesicle membrane] (R-HSA-194789) SYT1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869113)	0.623	4
UniProt:O43561-2 LAT	2	p-5Y-LAT-2 [plasma membrane] (R-HSA-2396597) LAT-2 [plasma membrane] (R-HSA-2396548)	0.556	3
UniProt:P78382 SLC35A1	2	SLC35A1 [Golgi membrane] (R-HSA-727812) SLC35A1 V93Cfs*17 [Golgi membrane] (R-HSA-5651957)	0.556	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:O75379 VAMP4	4	VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:P02787 TF	6	TF [endoplasmic reticulum lumen] (R-HSA-8956763) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) apoTF [extracellular region] (R-HSA-350754) apoTF [endosome membrane] (R-HSA-917974) TF [secretory granule lumen] (R-HSA-350704) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140)	0.556	3
UniProt:Q12982 BNIP2	1	BNIP2 [cytosol] (R-HSA-200792)	0.556	3

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