Reactome | PLA1A hydrolyses PS to 2-acyl LPS

PLA1A hydrolyses PS to 2-acyl LPS

Stable Identifier

R-HSA-8869425

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Phospholipase A1 member A (PLA1A, aka PS-PLA1) is a widely expressed, extracellular protein belonging to the pancreatic lipase family. Phospholipases are conserved in a wide range of organisms. PLA1A specifically hydrolyses PS to produce its corresponding lysophospholipid 2-acyl LPS. Lysophospholipids in general can act as lipid mediators with multiple biological functions so PLA1A could play an important role in mediating 2-acyl LPS production (Nagai et al. 1999, Aoki et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
10196188	An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans Arai, H, Matsuda, Y, Amano, K, Aoki, J, Sato, T, Inoue, K, Nagai, Y	J. Biol. Chem.	1999
17101204	Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family Saiki, N, Makide, K, Arai, H, Aoki, J, Inoue, A	Biochimie	2007