TNFAIP3 can remove K63-linked ubiquitin from TRAF6, which terminates signalling by Toll-like receptors (Boone et al. 2004). TNFAIP3 is essential for the termination of NFkappaB activation in response to multiple stimuli such as IL-1beta, TNF, IL-6, CD40 and lipopolysaccharide (LPS). Removal of K63-linked ubiquitin is not necessarily followed by K48-ubiquitination that would lead to degradation (Vereecke et al. 2009).
Turer, EE, Hurley, P, Ahmad, RC, Pickart, C, Tsui, C, Boone, DL, Chien, M, Chai, S, Ma, A, Lee, EG, Hitotsumatsu, O, Wheeler, MT, McNally, E
Lys63-specific deubiquitinase activity of OTUD7B,TNFAIP3,ZRANB1:K63polyUb-TRAF6 [cytosol]
© 2023 Reactome
