Reactome | oxLDL:CD36 binds TLR4:TLR6

oxLDL:CD36 binds TLR4:TLR6

Stable Identifier

R-HSA-8869667

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Oxidized low-density lipoprotein (oxLDL) and amyloid-beta sequestered by the scavenger receptor CD36 trigger sterile inflammatory signaling through a CD36:TLR4:TLR6 heteromerization (Stewart CR et al., 2010). The heterotrimeric CD36:TLR4:TLR6 signaling complex, acting via NFkappaB and reactive oxygen species, primes the NLRP3 inflammasome in response to oxLDL (Sheedy FJ et al., 2013).

Literature References

PubMed ID	Title	Journal	Year
7685021	CD36 is a receptor for oxidized low density lipoprotein Bryant, CM, White, RT, Madden, KS, Protter, AA, Stanton, LW, Endemann, G	J Biol Chem	1993
20037584	CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer El Khoury, J, Lacy-Hulbert, A, Boyer, L, van Gils, JM, Deng, J, Wilkinson, K, Halle, A, Stuart, LM, Moore, KJ, Zhong, R, Stewart, CR, Frazier, WA, Golenbock, DT, Rayner, KJ	Nat. Immunol.	2010