Reactome | RABGGTB [cytosol]

RABGGTB [cytosol]

Stable Identifier

R-HSA-8870419

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Geranylgeranyl transferase type-2 subunit beta ecNumber2.5.1.60/ecNumber, PGTB2_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q14161 GIT2

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External Reference Information

External Reference

UniProt:P53611 RABGGTB

Gene Names

RABGGTB, GGTB

Chain

initiator methionine:, chain:2-331

Reference Genes

BioGPS Gene:5876 RABGGTB

COSMIC (genes):RABGGTB RABGGTB

CTD Gene:5876 RABGGTB

dbSNP Gene:5876 RABGGTB

ENSEMBL:ENSG00000137955 RABGGTB

ENSEMBL_homo_sapiens_GENE:ENSG00000137955.16 RABGGTB

HGNC:9796 RABGGTB

KEGG Gene (Homo sapiens):5876 RABGGTB

Monarch:5876 RABGGTB

NCBI Gene:5876 RABGGTB

OMIM:179080 RABGGTB

Reference Transcript

RefSeq:NM_004582.3 RABGGTB

Other Identifiers

11724300_a_at

11757294_x_at

209180_PM_at

209180_at

209181_PM_s_at

209181_s_at

213704_PM_at

213704_at

2342633

2342637

2342638

2342639

2342640

2342644

2342649

2342650

2342652

2342656

2342658

2342659

2342660

2342662

37703_at

5876

781_at

7902382

A_14_P128168

A_23_P85371

A_24_P336705

A_33_P3311618

GO:0003824

GO:0004659

GO:0004663

GO:0005515

GO:0005829

GO:0005886

GO:0005968

GO:0007601

GO:0008270

GO:0008318

GO:0016740

GO:0018344

GO:0031267

GO:0036211

GO:0046872

GO:0050877

GO:0140096

HMNXSV003013751

ILMN_2163796

PH_hs_0004556

X98001_at

g1216503_3p_a_at

Participates

as an input of

as a component of

Other forms of this molecule

RABGGTB [plasma membrane]

Inferred To

RABGGTB [cytosol] (Bos taurus)

RABGGTB [cytosol] (Caenorhabditis elegans)

RABGGTB [cytosol] (Canis familiaris)

RABGGTB [cytosol] (Dictyostelium discoideum)

RABGGTB [cytosol] (Gallus gallus)

RABGGTB [cytosol] (Mus musculus)

RABGGTB [cytosol] (Plasmodium falciparum)

RABGGTB [cytosol] (Rattus norvegicus)

RABGGTB [cytosol] (Saccharomyces cerevisiae)

RABGGTB [cytosol] (Schizosaccharomyces pombe)

RabGGTb [cytosol] (Drosophila melanogaster)

Ghost homologue of RABGGTB [cytosol] (Sus scrofa)

Ghost homologue of RABGGTB [cytosol] (Xenopus tropicalis)

rabggtb [cytosol] (Danio rerio)

Cross References

RefSeq

NP_004573.2

OpenTargets

ENSG00000137955

IntEnz

2.5.1.60

HPA

ENSG00000137955-RABGGTB

GeneCards

P53611

Ensembl

ENSG00000137955, ENSP00000317473, ENST00000319942

PRO

P53611

Pharos - Targets

P53611

HMDB Protein

HMDBP11879

PDB

6J7X, 6J6X, 6J7F, 6J74, 6O60

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92696 RABGGTA	2	RABGGTA [plasma membrane] (R-HSA-6801086) RABGGTA [cytosol] (R-HSA-8870418)	0.8	8
UniProt:P57081 WDR4	1	WDR4 [nucleoplasm] (R-HSA-6782341)	0.718	6
UniProt:Q9UBV7 B4GALT7	4	B4GALT7 A186D [Golgi membrane] (R-HSA-3621785) B4GALT7 L206P [Golgi membrane] (R-HSA-3621790) B4GALT7 R270C [Golgi membrane] (R-HSA-3621734) B4GALT7 [Golgi membrane] (R-HSA-1889950)	0.718	6
UniProt:Q9Y3L5 RAP2C	2	RAP2C [plasma membrane] (R-HSA-6804983) RAP2C [tertiary granule membrane] (R-HSA-6804975)	0.643	3
UniProt:Q7Z6K3 PTAR1			0.643	4
UniProt:P20339 RAB5A	7	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [cytosol] (R-HSA-8870432) RAB5A [early endosome membrane] (R-HSA-2130175) RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257)	0.569	3
UniProt:Q7Z5A9 TAFA1			0.556	3
UniProt:Q86YD3 TMM25			0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q9BYB4 GNB1L			0.527	2
UniProt:Q96AH8 RAB7B	4	RAB7B [late endosome membrane] (R-HSA-8854158) GGC-RAB7B [lysosomal membrane] (R-HSA-8877450) GGC-RAB7B [cytosol] (R-HSA-8874059) RAB7B [cytosol] (R-HSA-8873707)	0.527	2
UniProt:Q12829 RAB40B	2	GGC-RAB40B [cytosol] (R-HSA-8874024) RAB40B [cytosol] (R-HSA-8873718)	0.527	3
UniProt:Q93096 TP4A1			0.527	3
UniProt:O94955 RHOBTB3	1	RHOBTB3 [trans-Golgi network membrane] (R-HSA-6813908)	0.527	2
UniProt:Q9NRW1 RAB6B	6	RAB6B [endoplasmic reticulum membrane] (R-HSA-8849252) RAB6B [trans-Golgi network membrane] (R-HSA-6810985) RAB6B [Golgi membrane] (R-HSA-8849249) GGC-RAB6B [trans-Golgi network membrane] (R-HSA-8876081) GGC-RAB6B [cytosol] (R-HSA-8874055) RAB6B [cytosol] (R-HSA-6810983)	0.527	3
UniProt:Q13636 RAB31	5	GGC-RAB31 [early endosome membrane] (R-HSA-8877278) GGC-RAB31 [cytosol] (R-HSA-8873974) RAB31 [cytosol] (R-HSA-8873690) RAB31 [plasma membrane] (R-HSA-6804813) RAB31 [secretory granule membrane] (R-HSA-6804797)	0.527	3
UniProt:Q9Y305 ACOT9	1	ACOT9 [mitochondrial matrix] (R-HSA-5690069)	0.527	2
UniProt:Q14642 INPP5A	1	INPP5A [plasma membrane] (R-HSA-1604583)	0.527	3
UniProt:Q8N414 PGBD5			0.527	2
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.527	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.527	2
UniProt:Q96QS6 PSKH2			0.527	2
UniProt:Q96S21 RAB40C	2	GGC-RAB40C [cytosol] (R-HSA-8874025) RAB40C [cytosol] (R-HSA-8873693)	0.527	3
UniProt:Q9UJC3 HOOK1			0.527	2
UniProt:P10114 RAP2A			0.527	3
UniProt:A2A3N6 PIPSL			0.527	2
UniProt:Q9UKA4 AKA11			0.527	2
UniProt:O15498 YKT6	5	PalmC-YKT6 [ER to Golgi transport vesicle membrane] (R-HSA-5688557) PalmC-YKT6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688558) PalmC-YKT6 [endoplasmic reticulum membrane] (R-HSA-5688145) PalmC-YKT6 [transport vesicle] (R-HSA-6808794) PalmC-YKT6 [Golgi membrane] (R-HSA-6808792)	0.527	3
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.527	3
UniProt:Q96H79 ZCCHL			0.527	2
UniProt:Q6PGQ7 BORA	3	p-S252-BORA [cytosol] (R-HSA-4086411) p-S252,S497,T501-BORA [cytosol] (R-HSA-3000330) BORA [cytosol] (R-HSA-2562607)	0.527	2
UniProt:Q9UM47 NOTCH3	20	Ub-NICD3 [cytosol] (R-HSA-9021546) Ub-NEXT3 [plasma membrane] (R-HSA-9021545) p-Y-NICD3 [cytosol] (R-HSA-9018581) Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911429) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911419) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911504) FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] (R-HSA-1911517) FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] (R-HSA-1911522) NOTCH3(40-1628) [extracellular region] (R-HSA-157639) NOTCH3(1629-1661) [plasma membrane] (R-HSA-157657) NEXT3 [plasma membrane] (R-HSA-157203) NICD3 [cytosol] (R-HSA-157647) NICD3 [nucleoplasm] (R-HSA-157928) Pre-NOTCH3 [endoplasmic reticulum membrane] (R-HSA-157102) 10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467382) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467307) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] (R-HSA-1472871) NOTCH3(1572-2321) [plasma membrane] (R-HSA-157231) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] (R-HSA-1983675) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] (R-HSA-1983672)	0.527	2
UniProt:O60331 PIP5K1C	1	PIP5K1C [cytosol] (R-HSA-392427)	0.527	2
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676)	0.527	3
UniProt:Q12974 PTP4A2	1	FarC-PTP4A2 [cytosol] (R-HSA-8870421)	0.527	2
UniProt:P51151 RAB9A	5	RAB9A [transport vesicle] (R-HSA-6814618) RAB9A [trans-Golgi network membrane] (R-HSA-6814616) GGC-RAB9A [trans-Golgi network membrane] (R-HSA-8876087) GGC-RAB9A [cytosol] (R-HSA-8874069) RAB9A [cytosol] (R-HSA-6813904)	0.527	2
UniProt:Q6UWZ7 FAM175A	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.527	2
UniProt:Q96I34 PP16A			0.527	2
UniProt:Q96AX2 RAB37	5	GGC-RAB37 [cytosol] (R-HSA-8873996) RAB37 [cytosol] (R-HSA-8873678) RAB37 [specific granule membrane] (R-HSA-6799605) RAB37 [plasma membrane] (R-HSA-6799686) RAB37 [azurophil granule membrane] (R-HSA-6799607)	0.488	2