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Phosphorylated FOXO3 translocates to the nucleus
Stable Identifier
R-HSA-8870628
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
nucleoplasm
ReviewStatus
5/5
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Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
Phosphorylated FOXO3 translocates to the nucleus (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CDK5-mediated phosphorylation of the transcription factor FOXO3 promotes translocation of FOXO3 from the cytosol to the nucleus (Shi et al. 2016).
Literature References
PubMed ID
Title
Journal
Year
26962010
Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models
Viccaro, K
,
Shi, C
,
Lee, HG
,
Shah, K
J. Cell. Sci.
2016
Participants
Input
p-S43,S173,S294,S325-FOXO3 [cytosol]
(Homo sapiens)
Output
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
Disease
Name
Identifier
Synonyms
Alzheimer's disease
DOID:10652
AD, Alzheimers dementia, Alzheimer disease
Authored
Shah, K (2016-02-23)
Created
Orlic-Milacic, M (2016-05-11)
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