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GAPVD1 [cytosol]
Stable Identifier
R-HSA-8871123
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GTPase-activating protein and VPS9 domain-containing protein 1, GAPD1_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAPVD1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAPVD1 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
GGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAPVD1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAPVD1 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAPVD1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GAPVD1 [cytosol] (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
RAB GEFs exchange GTP for GDP on RABs (Homo sapiens)
RAB31 GEFs exchange GTP for GDP on RAB31 (Homo sapiens)
RAB31 GEFs [cytosol] (Homo sapiens)
GAPVD1 [cytosol] (Homo sapiens)
RAB5 GEFs exchange GTP for GDP on RAB5 (Homo sapiens)
RAB5 GEFs [cytosol] (Homo sapiens)
GAPVD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14C86 GAPVD1
Gene Names
GAPVD1, GAPEX5, KIAA1521, RAP6
Chain
chain:1-1478
Reference Genes
BioGPS Gene:26130 GAPVD1
COSMIC (genes):GAPVD1 GAPVD1
CTD Gene:26130 GAPVD1
dbSNP Gene:26130 GAPVD1
ENSEMBL:ENSG00000165219 GAPVD1
HGNC:23375 GAPVD1
Monarch:26130 GAPVD1
NCBI Gene:26130 GAPVD1
OMIM:611714 GAPVD1
UCSC:Q14C86 GAPVD1
Reference Transcript
RefSeq:XM_017014608.1 GAPVD1
RefSeq:XM_011518502.2 GAPVD1
RefSeq:XM_005251904.3 GAPVD1
RefSeq:XM_017014600.1 GAPVD1
RefSeq:XM_017014609.1 GAPVD1
RefSeq:XM_017014601.1 GAPVD1
RefSeq:XM_006717044.3 GAPVD1
RefSeq:NM_001282679.1 GAPVD1
RefSeq:XM_017014602.1 GAPVD1
RefSeq:XM_017014603.1 GAPVD1
RefSeq:XM_011518500.2 GAPVD1
RefSeq:NM_001282681.1 GAPVD1
RefSeq:XM_017014607.1 GAPVD1
RefSeq:NM_015635.3 GAPVD1
RefSeq:NM_001282680.1 GAPVD1
RefSeq:XM_017014604.1 GAPVD1
RefSeq:XM_017014606.1 GAPVD1
RefSeq:XM_005251901.3 GAPVD1
RefSeq:XM_011518499.2 GAPVD1
RefSeq:NM_001330778.1 GAPVD1
Other Identifiers
11723348_a_at
11723349_x_at
11746385_a_at
11746976_a_at
11746977_a_at
11746978_a_at
11755390_a_at
11760639_at
17089056
212802_PM_s_at
212802_s_at
212804_PM_s_at
212804_s_at
214869_PM_x_at
214869_x_at
235553_PM_at
235553_at
26130
2904126
3189112
3189113
3189114
3189115
3189119
3189120
3189121
3189123
3189124
3189125
3189126
3189127
3189128
3189129
3189130
3189131
3189132
3189134
3189135
3189136
3189137
3189138
3189139
3189140
3189142
3189143
3189148
3189151
3189152
3189153
3189154
3189155
3189156
3189158
3189159
3189160
3189162
3189164
3189165
3189166
3189167
3189169
3189171
3189172
3189173
3189175
3189176
3189177
3189178
3189179
3189180
3189181
3189182
3189183
3189184
3189185
3189186
40801_at
40802_at
46396_at
8157858
A_14_P108216
A_23_P325891
A_23_P372660
A_23_P417575
A_24_P306209
A_32_P228414
A_33_P3265159
GE56360
GE641940
GE824187
GO:0005085
GO:0005096
GO:0005515
GO:0005768
GO:0005829
GO:0005886
GO:0006897
GO:0016020
GO:0016192
GO:0030139
GO:0031267
GO:0031410
GO:0032794
GO:0043087
GO:0043226
GO:0045296
GO:0051223
GO:0098772
HMNXSV003034611
HMNXSV003058308
Hs.172069.0.S1_3p_a_at
Hs.172069.0.S2_3p_a_at
Hs.306601.0.S1_3p_s_at
Hs.42376.0.A1_3p_at
ILMN_1671221
PH_hs_0003110
PH_hs_0023487
PH_hs_0032501
TC09000649.hg
Participates
as a component of
GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
GGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
as a member of
RAB5 GEFs [cytosol] (Homo sapiens)
RAB31 GEFs [cytosol] (Homo sapiens)
Inferred To
vps901 [cytosol]
(Schizosaccharomyces pombe)
Homologues of GAPVD1 [cytosol]
(Plasmodium falciparum)
rme-6 [cytosol]
(Caenorhabditis elegans)
GAPVD1 [cytosol]
(Bos taurus)
GAPVD1 [cytosol]
(Canis familiaris)
GAPVD1 [cytosol]
(Dictyostelium discoideum)
GAPVD1 [cytosol]
(Drosophila melanogaster)
GAPVD1 [cytosol]
(Gallus gallus)
GAPVD1 [cytosol]
(Plasmodium falciparum)
GAPVD1 [cytosol]
(Sus scrofa)
Gapvd1 [cytosol]
(Mus musculus)
Gapvd1 [cytosol]
(Rattus norvegicus)
VPS9 [cytosol]
(Saccharomyces cerevisiae)
Cross References
OpenTargets
ENSG00000165219
ENSEMBL
ENSP00000419767
,
ENSP00000377665
,
ENST00000470056
,
ENST00000297933
,
ENSP00000419063
,
ENST00000312123
,
ENSP00000377664
,
ENST00000495955
,
ENST00000394105
,
ENST00000394104
,
ENSP00000309582
,
ENSP00000297933
HPA
ENSG00000165219-GAPVD1
PRO
Q14C86
Pharos - Targets
Q14C86
Orphanet
GAPVD1
GlyGen
Q14C86
HMDB Protein
HMDBP08397
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.813
5
UniProt:P48730 CSNK1D
3
CSNK1D [nucleoplasm]
(R-HSA-421305)
CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5685717)
CSNK1D [cytosol]
(R-HSA-380315)
0.669
4
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cilium]
(R-HSA-5632507)
CSNK1A1 [cytosol]
(R-HSA-195263)
0.643
3
UniProt:P49674 CSNK1E
2
CSNK1E [cytosol]
(R-HSA-205877)
CSNK1E [nucleoplasm]
(R-HSA-421306)
0.643
5
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
2
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