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SORL1 [endosome membrane]
Stable Identifier
R-HSA-8871475
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
Sortilin-related receptor, SORL_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
SORL1 binds APP(18-770) (Homo sapiens)
SORL1 [endosome membrane] (Homo sapiens)
SORL1:APP(18-770) [endosome lumen] (Homo sapiens)
SORL1 [endosome membrane] (Homo sapiens)
SORL1 transports APP(18-770) from endosome lumen to Golgi lumen (Homo sapiens)
SORL1:APP(18-770) [endosome lumen] (Homo sapiens)
SORL1 [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92673 SORL1
Gene Names
SORL1, C11orf32
Chain
signal peptide:1-28, propeptide:29-81, chain:82-2214
Reference Genes
BioGPS Gene:6653 SORL1
COSMIC (genes):SORL1 SORL1
CTD Gene:6653 SORL1
dbSNP Gene:6653 SORL1
ENSEMBL:ENSG00000137642 SORL1
ENSEMBL_homo_sapiens_GENE:ENSG00000137642.13 SORL1
HGNC:11185 SORL1
KEGG Gene (Homo sapiens):6653 SORL1
Monarch:6653 SORL1
NCBI Gene:6653 SORL1
OMIM:602005 SORL1
UCSC:Q92673 SORL1
Reference Transcript
RefSeq:NM_003105.5 SORL1
Other Identifiers
11743129_at
11743130_a_at
16732584
203509_PM_at
203509_at
212560_PM_at
212560_at
32140_at
3352949
3352950
3352962
3352963
3352977
3352978
3352982
3352983
3352985
3352986
3352989
3352990
3352992
3352998
3353005
3353009
3353011
3353013
3353015
3353016
3353018
3353020
3353021
3353022
3353026
3353027
3353030
3353033
3353037
3353038
3353039
3353041
3353043
3353044
3353045
3353047
3353048
3353049
3353050
3353051
3353052
3353053
3353057
3353060
3353062
3353063
3353064
3353065
3353066
3353069
3353073
3353075
3353076
3353077
3353078
3353079
3353080
3564202
38411_at
6653
7944667
90218_at
A_14_P120661
A_14_P138519
A_23_P87049
GE59554
GE79051
GO:0000139
GO:0001540
GO:0002024
GO:0004888
GO:0005041
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005641
GO:0005768
GO:0005769
GO:0005771
GO:0005783
GO:0005789
GO:0005794
GO:0005802
GO:0005886
GO:0006605
GO:0006622
GO:0006629
GO:0006886
GO:0006892
GO:0006897
GO:0006898
GO:0007218
GO:0009986
GO:0010008
GO:0010897
GO:0014910
GO:0016020
GO:0016192
GO:0016477
GO:0019828
GO:0023052
GO:0030154
GO:0030163
GO:0030169
GO:0030514
GO:0030658
GO:0031267
GO:0031333
GO:0031410
GO:0031901
GO:0031985
GO:0032585
GO:0034067
GO:0038020
GO:0038024
GO:0042923
GO:0043025
GO:0043226
GO:0045053
GO:0045732
GO:0046628
GO:0048856
GO:0048870
GO:0050768
GO:0051604
GO:0055037
GO:0055038
GO:0060089
GO:0065003
GO:0070062
GO:0070863
GO:0072659
GO:0097356
GO:0098772
GO:0099638
GO:1900168
GO:1902430
GO:1902953
GO:1902955
GO:1902966
GO:1902992
GO:1902997
GO:1904179
GO:1990845
GO:2001137
HMNXSV003029070
Hs.82845.0.S1_3p_at
ILMN_1759818
ILMN_2060115
PH_hs_0025655
TC11001107.hg
TC11002916.hg
U60975_at
U90916_at
g6325473_3p_at
Participates
as a component of
SORL1:APP(18-770) [endosome lumen] (Homo sapiens)
as an input of
SORL1 binds APP(18-770) (Homo sapiens)
Other forms of this molecule
SORL1 [Golgi membrane]
Cross References
RefSeq
NP_003096.1
OpenTargets
ENSG00000137642
HPA
ENSG00000137642-SORL1
GeneCards
Q92673
Ensembl
ENSG00000137642
,
ENSP00000260197
,
ENST00000260197
PRO
Q92673
Pharos - Targets
Q92673
Orphanet
21201
PDB
3WSZ
,
7VT0
,
3WSY
,
3WSX
,
3G2T
,
3G2S
,
2DM4
Interactors (48)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92673-PRO_0000033164 SORL1
0.813
9
UniProt:P30533 AMRP
0.8
5
UniProt:Q9UJY4 GGA2
2
GGA2 [early endosome membrane]
(R-HSA-8854140)
GGA2 [endosome membrane]
(R-HSA-5692937)
0.774
6
UniProt:Q9UJY5 GGA1
2
GGA1 [early endosome membrane]
(R-HSA-8854136)
GGA1 [endosome membrane]
(R-HSA-5692930)
0.744
5
UniProt:P05067-4 APP
2
APP (535-695) [cytosol]
(R-HSA-9839084)
APP [mitochondrial inner membrane]
(R-HSA-9839060)
0.727
8
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.69
5
UniProt:P26992 CNTFR
1
CNTFR [plasma membrane]
(R-HSA-5696438)
0.672
7
UniProt:P08887 IL6R
1
IL6R [plasma membrane]
(R-HSA-197824)
0.619
7
UniProt:P05067-PRO_0000000093 APP
0.618
3
UniProt:P39905-PRO_0000034005 GDNF
0.571
6
UniProt:P05231 IL6
3
IL6 [extracellular region]
(R-HSA-447100)
IL6 [endoplasmic reticulum lumen]
(R-HSA-8956764)
p-IL6 [endoplasmic reticulum lumen]
(R-HSA-8957044)
0.571
4
UniProt:Q62997 Gfra1
2
GFRalpha-1 [plasma membrane]
(R-RNO-420354)
Gfra1 [plasma membrane]
(R-RNO-375067)
0.567
5
UniProt:Q96D03 DDT4L
0.556
3
UniProt:P20042 EIF2S2
1
EIF2S2 [cytosol]
(R-HSA-72512)
0.556
3
UniProt:P43681 CHRNA4
1
CHRNA4 [plasma membrane]
(R-HSA-507836)
0.556
3
UniProt:P78424 PO6F2
0.556
3
IntAct:EBI-25857140 ORF
0.556
3
IntAct:EBI-16882364 CALM1
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:P00491 PNP
7
PNP R234P [cytosol]
(R-HSA-9735772)
PNP E89K [cytosol]
(R-HSA-9735781)
PNP D128G [cytosol]
(R-HSA-9735785)
PNP [secretory granule lumen]
(R-HSA-6803318)
PNP [extracellular region]
(R-HSA-6806505)
PNP [ficolin-1-rich granule lumen]
(R-HSA-6803278)
PNP [cytosol]
(R-HSA-61933)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.556
3
UniProt:Q15669 RHOH
1
RHOH [plasma membrane]
(R-HSA-194859)
0.556
3
UniProt:Q8N0S8 Q8N0S8
0.556
3
UniProt:P05067-8 APP
0.554
2
UniProt:P56159-2 GFRA1
0.544
3
UniProt:O75462 CRLF1
2
CRLF1 [cytosol]
(R-HSA-8950296)
CRLF1 [extracellular region]
(R-HSA-5693174)
0.544
3
UniProt:O43301 HSPA12A
2
HSPA12A [cytosol]
(R-HSA-5252017)
HSPA12A [nucleoplasm]
(R-HSA-5252130)
0.543
5
UniProt:O00214 LEG8
0.527
2
UniProt:Q6ZMY9 ZNF517
1
ZNF517 [nucleoplasm]
(R-HSA-1973869)
0.527
2
UniProt:Q3SY56 SP6
0.527
3
UniProt:Q86Y25 ZNF354C
1
ZNF354C [nucleoplasm]
(R-HSA-1247525)
0.527
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
3
UniProt:Q14929 ZNF169
1
ZNF169 [nucleoplasm]
(R-HSA-975014)
0.527
2
UniProt:Q8TA94 ZNF563
1
ZNF563 [nucleoplasm]
(R-HSA-1973875)
0.527
2
UniProt:O43296 ZNF264
1
ZNF264 [nucleoplasm]
(R-HSA-1027386)
0.527
3
UniProt:Q8TDD2 SP7
1
SP7 [nucleoplasm]
(R-HSA-8939843)
0.527
2
UniProt:O95395 GCNT3
1
GCNT3 [Golgi membrane]
(R-HSA-914013)
0.527
4
UniProt:Q9NZL3 ZNF224
1
ZNF224 [nucleoplasm]
(R-HSA-1027352)
0.527
2
UniProt:P15408 FOSL2
0.527
3
UniProt:Q9NQX6 ZNF331
1
ZNF331 [nucleoplasm]
(R-HSA-1247549)
0.527
3
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.527
3
UniProt:Q8N8Y5 ZFP41
0.527
2
UniProt:Q9H9D4 ZN408
0.527
2
UniProt:P20036 HLA-DPA1
9
HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130667)
HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130739)
HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane]
(R-HSA-2214387)
HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane]
(R-HSA-2130337)
HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane]
(R-HSA-2130648)
HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130485)
HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane]
(R-HSA-2130435)
HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane]
(R-HSA-2130639)
HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane]
(R-HSA-197586)
0.527
2
UniProt:Q6IPR3 TYW3
1
TYW3 [cytoplasm]
(R-HSA-6782888)
0.527
3
UniProt:P05067-PRO_0000000091 APP
0.518
4
UniProt:O75462-PRO_0000011039 CRLF1
0.463
2
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