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ARHGEF10 [cytosol]
Stable Identifier
R-HSA-8873917
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rho guanine nucleotide exchange factor 10, ARHGA_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
ARHGEF10 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15013 ARHGEF10
Gene Names
ARHGEF10, KIAA0294
Chain
chain:1-1369
Reference Genes
BioGPS Gene:9639 ARHGEF10
COSMIC (genes):ARHGEF10 ARHGEF10
CTD Gene:9639 ARHGEF10
dbSNP Gene:9639 ARHGEF10
ENSEMBL:ENSG00000104728 ARHGEF10
ENSEMBL_homo_sapiens_GENE:ENSG00000104728.16 ARHGEF10
ENSEMBL_homo_sapiens_GENE:ENSG00000274726.4 ARHGEF10
HGNC:14103 ARHGEF10
KEGG Gene (Homo sapiens):9639 ARHGEF10
Monarch:9639 ARHGEF10
NCBI Gene:9639 ARHGEF10
OMIM:608136 ARHGEF10
UCSC:O15013 ARHGEF10
Reference Transcript
RefSeq:XM_017014003.1 ARHGEF10
RefSeq:NM_001308152.1 ARHGEF10
RefSeq:NM_014629.3 ARHGEF10
RefSeq:NM_001308153.1 ARHGEF10
Other Identifiers
11719650_a_at
17065173
216620_PM_s_at
216620_s_at
3082869
3082870
3082875
3082877
3082878
3082882
3082883
3082886
3082887
3082888
3082892
3082899
3082900
3082901
3082902
3082903
3082904
3082908
3082909
3082910
3082917
3082919
3082926
3082927
3082928
3082929
3082930
3082932
3082936
3082937
3082940
3082944
3082948
3082950
3082951
34180_at
8144281
9639
A_14_P108781
A_14_P134896
A_23_P216282
A_24_P283535
GE53036
GO:0000278
GO:0005085
GO:0005515
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0007010
GO:0007059
GO:0008092
GO:0019894
GO:0022011
GO:0023052
GO:0030036
GO:0030154
GO:0043226
GO:0048856
GO:0051056
GO:0051298
GO:0051496
GO:0090307
GO:0090630
GO:0098772
GO:0140014
HMNXSV003023354
Hs.20695.1.S1_3p_a_at
ILMN_2132809
PH_hs_0025482
TC08000010.hg
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
Inferred To
arhgef10 [cytosol]
(Xenopus tropicalis)
ARHGEF10 [cytosol]
(Bos taurus)
ARHGEF10 [cytosol]
(Canis familiaris)
ARHGEF10 [cytosol]
(Gallus gallus)
ARHGEF10 [cytosol]
(Sus scrofa)
Arhgef10 [cytosol]
(Mus musculus)
Arhgef10 [cytosol]
(Rattus norvegicus)
CG12432 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001295082.1
,
NP_055444.2
,
XP_016869492.1
,
NP_001295081.1
OpenTargets
ENSG00000104728
HPA
ENSG00000104728-ARHGEF10
GeneCards
O15013
Ensembl
ENSP00000481974
,
ENST00000619613
,
ENSP00000340297
,
ENSG00000274726
,
ENST00000610399
,
ENST00000518288
,
ENSP00000381571
,
ENSG00000104728
,
ENST00000633616
,
ENST00000520359
,
ENST00000631758
,
ENST00000349830
,
ENST00000398564
,
ENSP00000427909
,
ENSP00000488463
,
ENSP00000431012
,
ENSP00000488343
,
ENSP00000477988
PRO
O15013
Pharos - Targets
O15013
Orphanet
21726
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.483
3
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