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ARHGAP21 [cytosol]
Stable Identifier
R-HSA-8873918
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rho GTPase-activating protein 21, RHG21_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)
CDC42 GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
RAC1 GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)
RAC2 GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)
RAC3 GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)
RHOA GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)
RHOB GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)
RHOC GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RHOD GTPase cycle (Homo sapiens)
RHOD GAPs stimulate RHOD GTPase activity (Homo sapiens)
RHOD GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RHOF GTPase cycle (Homo sapiens)
RHOF GAPs stimulate RHOF GTPase activity (Homo sapiens)
RHOF GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG GAPs stimulate RHOG GTPase activity (Homo sapiens)
RHOG GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)
RHOJ GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RHOQ GTPase cycle (Homo sapiens)
RHOQ GAPs stimulate RHOQ GTPase activity (Homo sapiens)
RHOQ GAPs [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RND3 GTPase cycle (Homo sapiens)
RND3 binds effectors (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
RND3:GTP:RND3 effectors [plasma membrane] (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
ARHGAP21 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5T5U3 ARHGAP21
Gene Names
ARHGAP21, ARHGAP10, KIAA1424
Chain
chain:1-1958
Reference Genes
BioGPS Gene:57584 ARHGAP21
COSMIC (genes):ARHGAP21 ARHGAP21
CTD Gene:57584 ARHGAP21
dbSNP Gene:57584 ARHGAP21
ENSEMBL:ENSG00000107863 ARHGAP21
ENSEMBL_homo_sapiens_GENE:ENSG00000107863.20 ARHGAP21
HGNC:23725 ARHGAP21
KEGG Gene (Homo sapiens):57584 ARHGAP21
Monarch:57584 ARHGAP21
NCBI Gene:57584 ARHGAP21
OMIM:609870 ARHGAP21
UCSC:Q5T5U3 ARHGAP21
Reference Transcript
RefSeq:XM_005252542.3 ARHGAP21
RefSeq:XM_017016459.1 ARHGAP21
RefSeq:NM_020824.3 ARHGAP21
Other Identifiers
11718745_s_at
11718746_x_at
11751946_a_at
16712531
224764_PM_at
224764_at
241701_PM_at
241701_at
2962159
2962160
2962161
2962162
2962163
2962164
2962165
2962166
2962167
2962168
2962170
2962173
2962174
2962175
2962176
2962177
2962179
2962180
2962182
2962184
2962185
2962186
2962187
2962188
2962190
2962191
2962195
2962196
3281622
3281623
3281624
3281625
3281628
3281632
3281635
3281636
3281637
3281638
3281639
3281641
3281643
3281645
3281646
3281647
3281649
3281651
3281652
3281653
3281654
3281659
3281660
3281662
3281667
3281668
3281670
3281675
3281677
3281696
3281697
3281700
3281702
3680091
3680097
52927_at
57584
74818_at
77357_at
7932554
80095_at
A_23_P115608
GE53961
GO:0000139
GO:0005096
GO:0005515
GO:0005737
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0007018
GO:0007030
GO:0007165
GO:0015629
GO:0016020
GO:0023052
GO:0030054
GO:0030659
GO:0031410
GO:0043226
GO:0051056
GO:0051645
GO:0051683
GO:0051684
GO:0070161
GO:0072384
GO:0098772
HMNXSV003022750
Hs.11611.0.A1_3p_at
Hs.146101.0.S1_3p_at
ILMN_1811592
PH_hs_0030112
PH_hs_0033235
TC10001109.hg
Participates
as a member of
RHOA GAPs [cytosol] (Homo sapiens)
as a candidate of
RND3 effectors [cytosol] (Homo sapiens)
RHOC GAPs [cytosol] (Homo sapiens)
RHOQ GAPs [cytosol] (Homo sapiens)
CDC42 GAPs [cytosol] (Homo sapiens)
RAC2 GAPs [cytosol] (Homo sapiens)
RHOD GAPs [cytosol] (Homo sapiens)
RAC1 GAPs [cytosol] (Homo sapiens)
RHOF GAPs [cytosol] (Homo sapiens)
RHOB GAPs [cytosol] (Homo sapiens)
RHOG GAPs [cytosol] (Homo sapiens)
RHOJ GAPs [cytosol] (Homo sapiens)
RAC3 GAPs [cytosol] (Homo sapiens)
Inferred To
arhgap21 [cytosol]
(Xenopus tropicalis)
ARHGAP21 [cytosol]
(Bos taurus)
ARHGAP21 [cytosol]
(Canis familiaris)
ARHGAP21 [cytosol]
(Gallus gallus)
ARHGAP21 [cytosol]
(Sus scrofa)
Arhgap21 [cytosol]
(Mus musculus)
Arhgap21 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_016871948.1
,
XP_005252599.1
,
NP_065875.3
OpenTargets
ENSG00000107863
HPA
ENSG00000107863-ARHGAP21
GeneCards
Q5T5U3
Ensembl
ENST00000396432
,
ENSG00000107863
,
ENSP00000379709
PRO
Q5T5U3
Pharos - Targets
Q5T5U3
PDB
2J59
,
2DHJ
,
2YUY
HMDB Protein
HMDBP08549
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.763
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.569
4
UniProt:P84078
2
ARF1 [cytosol]
(R-MMU-200826)
ARF1 [Golgi membrane]
(R-MMU-199971)
0.558
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.536
4
UniProt:P29692 EEF1D
1
EEF1D [cytosol]
(R-HSA-156914)
0.524
2
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