Reactome | CREB3(1-291) [Golgi membrane]

CREB3(1-291) [Golgi membrane]

Stable Identifier

R-HSA-8874181

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Cyclic AMP-responsive element-binding protein 3, CREB3_HUMAN

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
12138176	Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis O'Hare, P, Raggo, C, Gobeil, P, Misra, V, Smith-Windsor, E, Stirling, J, Rapin, N	Mol. Cell. Biol.	2002

External Reference Information

External Reference

UniProt:O43889 CREB3

Gene Names

CREB3, LZIP

Chain

chain:1-371, chain:1-

Reference Genes

BioGPS Gene:10488 CREB3

COSMIC (genes):CREB3 CREB3

CTD Gene:10488 CREB3

dbSNP Gene:10488 CREB3

ENSEMBL:ENSG00000107175 CREB3

HGNC:2347 CREB3

KEGG:hsa:10488 CREB3

Monarch:10488 CREB3

NCBI Gene:10488 CREB3

OMIM:606443 CREB3

UCSC:O43889 CREB3

Reference Transcript

RefSeq:NM_006368.4 CREB3

Participates

as an output of

MBTPS1 (S1P) cleaves CREB3 (Homo sapiens)

as an input of

MBTPS2 (S2P) cleaves CREB3 (Homo sapiens)

Other forms of this molecule

CREB3(1-256) [nucleoplasm]

CREB3(1-256) [cytosol]

CREB3(257-291) [Golgi membrane]

CREB3 [Golgi membrane]

CREB3(292-371) [Golgi membrane]

CREB3 [endoplasmic reticulum membrane]

Inferred To

let-607 [Golgi membrane] (Caenorhabditis elegans)

Creb3 [Golgi membrane] (Mus musculus)

Creb3 [Golgi membrane] (Rattus norvegicus)

CREB3(1-291) [Golgi membrane] (Gallus gallus)

CREB3 [Golgi membrane] (Bos taurus)

CREB3 [Golgi membrane] (Canis familiaris)

CREB3 [Golgi membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000342136, ENSG00000107175, ENST00000353704

OpenTargets

ENSG00000107175

GeneCards

CREB3

HPA

ENSG00000107175-CREB3

PRO

O43889

Pharos - Targets

O43889

GlyGen

O43889

HMDB Protein

HMDBP08122

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.802	7
UniProt:Q92685 ALG3	5	ALG3 R171Q [endoplasmic reticulum membrane] (R-HSA-4720470) ALG3 M157K [endoplasmic reticulum membrane] (R-HSA-4720484) ALG3 G118D [endoplasmic reticulum membrane] (R-HSA-4720468) ALG3 W71R [endoplasmic reticulum membrane] (R-HSA-4720466) ALG3 [endoplasmic reticulum membrane] (R-HSA-449287)	0.729	4
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.623	2
UniProt:Q9NS37 ZHANG			0.623	3
UniProt:Q68CJ9 CREB3L3	10	CREB3L3(1-?) [nucleoplasm] (R-HSA-6784629) CREB3L3(1-?) [cytosol] (R-HSA-6784654) CREB3L3 [endoplasmic reticulum membrane] (R-HSA-6784669) CREB3L3(?-461) [endoplasmic reticulum membrane] (R-HSA-6784710) CREB3L3 [Golgi membrane] (R-HSA-8874144) CREB3L3(365-461) [Golgi membrane] (R-HSA-8874130) CREB3L3(1-364) [Golgi membrane] (R-HSA-8874158) CREB3L3(1-323) [cytosol] (R-HSA-8874214) CREB3L3(1-323) [nucleoplasm] (R-HSA-8874217) CREB3L3(324-364) [Golgi membrane] (R-HSA-8874183)	0.623	3
UniProt:O43889 CREB3	7	CREB3(1-256) [nucleoplasm] (R-HSA-8874190) CREB3(1-256) [cytosol] (R-HSA-8874135) CREB3(1-291) [Golgi membrane] (R-HSA-8874181) CREB3(257-291) [Golgi membrane] (R-HSA-8874207) CREB3 [Golgi membrane] (R-HSA-8874123) CREB3(292-371) [Golgi membrane] (R-HSA-8874173) CREB3 [endoplasmic reticulum membrane] (R-HSA-8874165)	0.592	2
UniProt:O00268 TAF4	1	TAF4 [nucleoplasm] (R-HSA-65541)	0.558	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.553	2
UniProt:Q9UNK0 STX8			0.553	2
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.553	2
UniProt:P48230 T4S4			0.553	2
UniProt:Q9NV12 TM140			0.553	2
UniProt:O95870 ABHGA			0.553	2
UniProt:Q9Y3D6 FIS1	2	FIS1 [peroxisomal membrane] (R-HSA-9033123) FIS1 [cytosol] (R-HSA-9033099)	0.553	2
UniProt:Q9NW97 TMM51			0.553	2
UniProt:Q9BQA9 CYBC1			0.553	2
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.553	2
UniProt:Q53HI1 UNC50			0.553	2
UniProt:P02652 APOA2	6	APOA2(24-100) [cytosol] (R-HSA-2395772) APOA2(24-100) [early endosome] (R-HSA-2569092) APOA2(24-100) [endoplasmic reticulum lumen] (R-HSA-174689) APOA2(24-100) [extracellular region] (R-HSA-174775) p-APOA2 [endoplasmic reticulum lumen] (R-HSA-8957014) APOA2 [endoplasmic reticulum lumen] (R-HSA-8956780)	0.553	2
UniProt:Q14802 FXYD3	1	FXYD3 [plasma membrane] (R-HSA-2752084)	0.553	2
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.553	2
UniProt:Q9NQQ7 S35C2			0.553	2
UniProt:Q99675 CGRF1			0.553	2
UniProt:Q96LL9 DJC30			0.553	2
UniProt:Q9NX47 MARH5			0.553	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.524	4
UniProt:Q8TEY5 CREB3L4	7	CREB3L4(298-338) [Golgi membrane] (R-HSA-8874221) CREB3L4(1-297) [nucleoplasm] (R-HSA-8874220) CREB3L4(1-297) [cytosol] (R-HSA-8874188) CREB3L4(339-395) [Golgi membrane] (R-HSA-8874140) CREB3L4(1-338) [Golgi membrane] (R-HSA-8874180) CREB3L4 [Golgi membrane] (R-HSA-8874128) CREB3L4 [endoplasmic reticulum membrane] (R-HSA-8874168)	0.483	2

Cite Us!