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MBTPS2 (S2P) cleaves CREB3L2
Stable Identifier
R-HSA-8874187
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane
,
cytosol
ReviewStatus
5/5
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
CREB3 factors activate genes (Homo sapiens)
MBTPS2 (S2P) cleaves CREB3L2 (Homo sapiens)
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MBTPS2 (S2P) cleaves CREB3L2 near the cytoplasmic face of the transmembrane domain, releasing the cytoplasmic N-terminal domain into the cytosol (inferred from human ATF6-alpha and mouse homologs).
Participants
Input
CREB3L2(1-430) [Golgi membrane]
(Homo sapiens)
Output
CREB3L2(1-379) [cytosol]
(Homo sapiens)
CREB3L2(380-430) [Golgi membrane]
(Homo sapiens)
Participates
as an event of
CREB3 factors activate genes (Homo sapiens)
Catalyst Activity
metalloendopeptidase activity of MBTPS2 [Golgi membrane]
Physical Entity
MBTPS2 [Golgi membrane]
(Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Inferred From
Mbtps2 (S2P) cleaves Creb3l2 (BBF2H7) (Mus musculus)
Authored
May, B (2016-05-21)
Reviewed
Schröder, M (2017-02-25)
Created
May, B (2016-05-21)
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