Reactome | CREB3(257-291) [Golgi membrane]

CREB3(257-291) [Golgi membrane]

Stable Identifier

R-HSA-8874207

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Cyclic AMP-responsive element-binding protein 3, CREB3_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
12138176	Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis O'Hare, P, Raggo, C, Gobeil, P, Misra, V, Smith-Windsor, E, Stirling, J, Rapin, N	Mol. Cell. Biol.	2002

External Reference Information

External Reference

UniProt:O43889 CREB3

Gene Names

CREB3, LZIP

Chain

chain:1-371, chain:1-

Reference Genes

BioGPS Gene:10488 CREB3

COSMIC (genes):CREB3 CREB3

CTD Gene:10488 CREB3

dbSNP Gene:10488 CREB3

ENSEMBL:ENSG00000107175 CREB3

ENSEMBL_homo_sapiens_GENE:ENSG00000107175.12 CREB3

HGNC:2347 CREB3

KEGG Gene (Homo sapiens):10488 CREB3

Monarch:10488 CREB3

NCBI Gene:10488 CREB3

OMIM:606443 CREB3

UCSC:O43889 CREB3

Reference Transcript

RefSeq:NM_006368.4 CREB3

Other Identifiers

10488

11723024_a_at

17084736

209432_PM_s_at

209432_s_at

3168106

3168107

3168108

3168110

3168111

3168112

3168114

3168115

3168117

3168118

3168119

3168120

40849_s_at

8155096

AF009368_at

A_14_P200251

GE59521

GO:0000139

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001221

GO:0001228

GO:0001558

GO:0002230

GO:0002376

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006935

GO:0006986

GO:0008140

GO:0012501

GO:0016020

GO:0016604

GO:0019043

GO:0019046

GO:0023052

GO:0030335

GO:0030968

GO:0031726

GO:0042127

GO:0042802

GO:0042803

GO:0042981

GO:0042994

GO:0043025

GO:0043226

GO:0045786

GO:0045893

GO:0045944

GO:0046983

GO:0048870

GO:0050930

GO:0051928

GO:0090026

GO:0090575

GO:0098542

GO:0140110

GO:0140467

GO:1902236

GO:1990837

HMNXSV003030571

ILMN_1703072

PH_hs_0014926

TC09000192.hg

g2599559_3p_a_at

Participates

as an output of

MBTPS2 (S2P) cleaves CREB3 (Homo sapiens)

Other forms of this molecule

CREB3(1-256) [nucleoplasm]

CREB3(1-256) [cytosol]

CREB3(1-291) [Golgi membrane]

CREB3 [Golgi membrane]

CREB3(292-371) [Golgi membrane]

CREB3 [endoplasmic reticulum membrane]

Cross References

RefSeq

NP_006359.3

OpenTargets

ENSG00000107175

HPA

ENSG00000107175-CREB3

GeneCards

O43889

Ensembl

ENSP00000342136, ENSG00000107175, ENST00000353704

PRO

O43889

Pharos - Targets

O43889

HMDB Protein

HMDBP08122

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.802	7
UniProt:Q92685 ALG3	5	ALG3 [endoplasmic reticulum membrane] (R-HSA-449287) ALG3 W71R [endoplasmic reticulum membrane] (R-HSA-4720466) ALG3 G118D [endoplasmic reticulum membrane] (R-HSA-4720468) ALG3 M157K [endoplasmic reticulum membrane] (R-HSA-4720484) ALG3 R171Q [endoplasmic reticulum membrane] (R-HSA-4720470)	0.729	4
UniProt:Q68CJ9 CREB3L3	10	CREB3L3(1-?) [nucleoplasm] (R-HSA-6784629) CREB3L3(1-?) [cytosol] (R-HSA-6784654) CREB3L3 [endoplasmic reticulum membrane] (R-HSA-6784669) CREB3L3(?-461) [endoplasmic reticulum membrane] (R-HSA-6784710) CREB3L3 [Golgi membrane] (R-HSA-8874144) CREB3L3(365-461) [Golgi membrane] (R-HSA-8874130) CREB3L3(1-364) [Golgi membrane] (R-HSA-8874158) CREB3L3(1-323) [cytosol] (R-HSA-8874214) CREB3L3(1-323) [nucleoplasm] (R-HSA-8874217) CREB3L3(324-364) [Golgi membrane] (R-HSA-8874183)	0.623	3
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.623	2
UniProt:Q9NS37 ZHANG			0.623	3
UniProt:O43889 CREB3	7	CREB3(1-256) [nucleoplasm] (R-HSA-8874190) CREB3(1-256) [cytosol] (R-HSA-8874135) CREB3(1-291) [Golgi membrane] (R-HSA-8874181) CREB3(257-291) [Golgi membrane] (R-HSA-8874207) CREB3 [Golgi membrane] (R-HSA-8874123) CREB3(292-371) [Golgi membrane] (R-HSA-8874173) CREB3 [endoplasmic reticulum membrane] (R-HSA-8874165)	0.592	2
UniProt:O00268 TAF4	1	TAF4 [nucleoplasm] (R-HSA-65541)	0.558	2
UniProt:Q9NX47 MARH5			0.553	2
UniProt:Q96LL9 DJC30			0.553	2
UniProt:Q99675 CGRF1			0.553	2
UniProt:Q9NQQ7 S35C2			0.553	2
UniProt:Q14802 FXYD3	1	FXYD3 [plasma membrane] (R-HSA-2752084)	0.553	2
UniProt:Q53HI1 UNC50			0.553	2
UniProt:Q9Y287 ITM2B	1	ITM2B(244-266) [extracellular region] (R-HSA-976878)	0.553	2
UniProt:Q9BQA9 CYBC1			0.553	2
UniProt:Q9NW97 TMM51			0.553	2
UniProt:Q9Y3D6 FIS1	2	FIS1 [peroxisomal membrane] (R-HSA-9033123) FIS1 [cytosol] (R-HSA-9033099)	0.553	2
UniProt:O95870 ABHGA			0.553	2
UniProt:Q9NV12 TM140			0.553	2
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.553	2
UniProt:P02652 APOA2	6	APOA2(24-100) [cytosol] (R-HSA-2395772) APOA2(24-100) [early endosome] (R-HSA-2569092) APOA2(24-100) [endoplasmic reticulum lumen] (R-HSA-174689) APOA2(24-100) [extracellular region] (R-HSA-174775) p-APOA2 [endoplasmic reticulum lumen] (R-HSA-8957014) APOA2 [endoplasmic reticulum lumen] (R-HSA-8956780)	0.553	2
UniProt:Q96CM8 ACSF2	1	ACSF2 [mitochondrial matrix] (R-HSA-5696005)	0.553	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.553	2
UniProt:Q9UNK0 STX8			0.553	2
UniProt:P48230 T4S4			0.553	2
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.524	4
UniProt:Q8TEY5 CREB3L4	7	CREB3L4(298-338) [Golgi membrane] (R-HSA-8874221) CREB3L4 [endoplasmic reticulum membrane] (R-HSA-8874168) CREB3L4 [Golgi membrane] (R-HSA-8874128) CREB3L4(1-338) [Golgi membrane] (R-HSA-8874180) CREB3L4(339-395) [Golgi membrane] (R-HSA-8874140) CREB3L4(1-297) [cytosol] (R-HSA-8874188) CREB3L4(1-297) [nucleoplasm] (R-HSA-8874220)	0.483	2

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