Reactome | TMEM86B [endoplasmic reticulum membrane]

TMEM86B [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-8874443

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Lysoplasmalogenase ecNumber3.3.2.2/ecNumber ecNumber3.3.2.5/ecNumber, TM86B_HUMAN

Locations in the PathwayBrowser for interactor UniProt:A0AVG3 A0AVG3

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External Reference Information

External Reference

UniProt:Q8N661 TMEM86B

Gene Names

TMEM86B

Chain

chain:1-226

Reference Genes

BioGPS Gene:255043 TMEM86B

COSMIC (genes):TMEM86B TMEM86B

CTD Gene:255043 TMEM86B

dbSNP Gene:255043 TMEM86B

ENSEMBL:ENSG00000180089 TMEM86B

HGNC:28448 TMEM86B

Monarch:255043 TMEM86B

NCBI Gene:255043 TMEM86B

OMIM:617806 TMEM86B

UCSC:Q8N661 TMEM86B

Reference Transcript

RefSeq:NM_173804.4 TMEM86B

Other Identifiers

11754415_a_at

16875677

229736_PM_at

229736_at

255043

3871243

3871244

3871245

3871246

3871247

3871248

3871249

3871250

3871251

3871252

3871253

3871254

3871255

76852_at

8039409

A_24_P121956

GE495160

GO:0003824

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0006629

GO:0016020

GO:0016787

GO:0016803

GO:0016853

GO:0036151

GO:0042802

GO:0043226

GO:0046485

GO:0047408

GO:0047826

HMNXSV003036862

Hs.135215.0.A1_3p_at

ILMN_2049417

PH_hs_0008163

TC19001863.hg

Inferred To

TMEM86B [endoplasmic reticulum membrane] (Bos taurus)

TMEM86B [endoplasmic reticulum membrane] (Caenorhabditis elegans)

TMEM86B [endoplasmic reticulum membrane] (Canis familiaris)

TMEM86B [endoplasmic reticulum membrane] (Sus scrofa)

Dmel\CG7582 [endoplasmic reticulum membrane] (Drosophila melanogaster)

tmem86b [endoplasmic reticulum membrane] (Danio rerio)

tmem86b [endoplasmic reticulum membrane] (Xenopus tropicalis)

Homologues of TMEM86B [endoplasmic reticulum membrane] (Danio rerio)

Homologues of TMEM86B [endoplasmic reticulum membrane] (Xenopus tropicalis)

Tmem86b [endoplasmic reticulum membrane] (Mus musculus)

Tmem86b [endoplasmic reticulum membrane] (Rattus norvegicus)

tmem86 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

tmem86a [endoplasmic reticulum membrane] (Danio rerio)

tmem86a [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000180089

ENSEMBL

ENST00000327042, ENSP00000321038

HPA

ENSG00000180089-TMEM86B

PRO

Q8N661

Pharos - Targets

Q8N661

HMDB Protein

HMDBP11979

Interactors (106)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXK5 B2L13			0.718	6
UniProt:P43628 KIR2DL3	1	KIR2DL3 [plasma membrane] (R-HSA-3006532)	0.556	3
UniProt:Q96LL9 DJC30			0.556	3
UniProt:O95183 VAMP5			0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q9H2L4 TMM60			0.556	3
UniProt:B2RUZ4 SMIM1			0.556	3
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.556	3
UniProt:Q86Y82 STX12			0.556	3
UniProt:Q9Y680 FKBP7			0.556	3
UniProt:Q9Y320 TMX2			0.556	3
UniProt:Q8WV19 SFT2A			0.556	3
IntAct:EBI-23641393 CCSB ORF ID			0.556	3
UniProt:Q9H0Q3 FXYD6	1	FXYD6 [plasma membrane] (R-HSA-2752104)	0.556	3
UniProt:P30040 ERP29			0.556	3
UniProt:Q9H400 LIME1			0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:P35212 GJA4	1	GJA4 [endoplasmic reticulum membrane] (R-HSA-190657)	0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:P31937 HIBADH	1	HIBADH [mitochondrial matrix] (R-HSA-70882)	0.556	3
UniProt:P26678 PLN	2	p-S16-PLN [sarcoplasmic reticulum membrane] (R-HSA-5578813) PLN [sarcoplasmic reticulum membrane] (R-HSA-5490319)	0.556	3
IntAct:EBI-23642082 CCSB ORF ID			0.556	3
UniProt:Q8TEB9 RHBL4			0.556	3
UniProt:Q96JA4 M4A14			0.556	3
UniProt:Q9NUM3 S39A9			0.556	3
UniProt:Q8N474 SFRP1	1	SFRP1 [extracellular region] (R-HSA-2980916)	0.556	3
UniProt:Q96HJ3-2 Q96HJ32			0.556	3
UniProt:Q02747 GUCA2A	1	GUCA2A(22-115) [extracellular region] (R-HSA-8936191)	0.556	3
UniProt:Q9NUU6 OTULL			0.556	3
UniProt:Q9P0N8 MARH2			0.556	3
UniProt:Q9Y6G1 TM14A			0.556	3
UniProt:Q9GZY8-5 MFF			0.556	6
UniProt:A0AVG3 A0AVG3			0.556	3
UniProt:Q6UX40 TM107			0.556	3
UniProt:Q9Y5U9 IR3IP			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:O95393 BMP10	2	BMP10(22-424) [extracellular region] (R-HSA-2396409) BMP10 [extracellular region] (R-HSA-8858374)	0.556	3
UniProt:P58418 CLRN1			0.556	3
UniProt:Q9UNK0 STX8			0.556	3
UniProt:Q96IV6 FXDC2			0.556	3
UniProt:O15393-2 TMPRSS2			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q14210 LY6D	2	cleaved GPI-LY6D [extracellular region] (R-HSA-8941095) GPI-LY6D [plasma membrane] (R-HSA-8940697)	0.556	3
UniProt:Q6UX34 SNORC			0.556	3
UniProt:Q9NZG7 NINJ2			0.556	3
UniProt:P15941-11 MUC1			0.556	3
UniProt:P48165 GJA8	1	GJA8 [endoplasmic reticulum membrane] (R-HSA-190702)	0.556	3
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.556	3
UniProt:Q96A25 T106A			0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:O14524-2 NEMP1			0.556	3
UniProt:Q9P0L0 VAPA	4	VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [cytosol] (R-HSA-9609920)	0.556	3
UniProt:P07307-3 ASGR2			0.556	3
UniProt:P07204 THBD	1	THBD [plasma membrane] (R-HSA-141030)	0.556	3
UniProt:Q969S6 TM203			0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425) VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129)	0.556	3
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:P34910-2 P349102			0.556	3
UniProt:O14880 MGST3	1	MGST3 [endoplasmic reticulum membrane] (R-HSA-176053)	0.556	3
UniProt:P19397 CD53	3	CD53 [tertiary granule membrane] (R-HSA-6804799) CD53 [plasma membrane] (R-HSA-6804817) CD53 [specific granule membrane] (R-HSA-6804793)	0.556	3
UniProt:Q8N5I4 DHRSX			0.556	3
UniProt:O14523 C2C2L			0.556	3
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.556	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:P48449 LSS	1	LSS [endoplasmic reticulum membrane] (R-HSA-191371)	0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:P17302 GJA1	7	GJA1 [Golgi-associated vesicle membrane] (R-HSA-190544) GJA1 [plasma membrane] (R-HSA-158058) p-Y265-GJA1 [plasma membrane] (R-HSA-191657) GJA1 [lysosomal membrane] (R-HSA-196173) GJA1 [endoplasmic reticulum membrane] (R-HSA-190654) GJA1 [Golgi membrane] (R-HSA-190649) p-S373-GJA1 [plasma membrane] (R-HSA-9857671)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q15800 MSMO1	1	MSMO1 [endoplasmic reticulum membrane] (R-HSA-194648)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:O60883 GPR37L1	1	GPR37L1 [plasma membrane] (R-HSA-5336178)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.556	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q9Y624 F11R	2	F11R [cell junction] (R-HSA-2134498) F11R [plasma membrane] (R-HSA-197845)	0.556	3
UniProt:Q13323 BIK			0.556	3
UniProt:Q8N966 ZDH22			0.556	3
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.556	3
UniProt:Q8TD22 SFXN5			0.556	3
UniProt:O43169 CYB5B	2	CYB5B [endoplasmic reticulum membrane] (R-HSA-9842695) CYB5B [mitochondrial outer membrane] (R-HSA-8943390)	0.556	3
UniProt:Q9NSU2-1 TREX1			0.556	3
UniProt:P27105 STOM	4	STOM [azurophil granule membrane] (R-HSA-6800997) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [tertiary granule membrane] (R-HSA-6800960)	0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	5
UniProt:Q07326 PIGF	1	PIGF [endoplasmic reticulum membrane] (R-HSA-162819)	0.556	3
UniProt:Q9P0S9 TM14C			0.556	3
UniProt:Q01628 IFITM3	1	IFITM3 [plasma membrane] (R-HSA-1015688)	0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q9BXJ8 TACAN			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q9NWD8 TM248			0.556	3
UniProt:Q86VI4 LAP4B			0.556	3
UniProt:Q8WY91 THAP4			0.556	3
UniProt:Q9P0B6 CC167			0.556	3
UniProt:Q8IXI1 RHOT2	1	RHOT2 [mitochondrial outer membrane] (R-HSA-3006730)	0.556	3
UniProt:Q96FB2 Q96FB2			0.556	3
UniProt:Q53FV1 ORMDL2	1	ORMDL2 [endoplasmic reticulum membrane] (R-HSA-8865591)	0.556	3
UniProt:Q8TBE7 S35G2			0.556	3
UniProt:P13236 CCL4	1	CCL4(24-92) [extracellular region] (R-HSA-443976)	0.556	3
UniProt:Q9Y375 NDUFAF1	1	NDUFAF1 [mitochondrial inner membrane] (R-HSA-5689050)	0.556	3
UniProt:Q8N6K0 TEX29			0.556	3
UniProt:Q8N6S5 AR6P6			0.556	3
UniProt:O14925 TIMM23	2	TIMM23 [mitochondrial intermembrane space] (R-HSA-1299436) TIMM23 [mitochondrial inner membrane] (R-HSA-1252126)	0.556	3
UniProt:Q96HA9 PX11C			0.556	3

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