ACSM3,ACSM6 ligate CoA to BUT

Stable Identifier
Reaction [transition]
Homo sapiens
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Mitochondrial acyl-coenzyme A synthetase ACSM3 (aka protein SAH homolog) is expressed in the mitochondrial matrix and possesses medium-chain fatty acid:CoA ligase activity. Based on characterisation experiments in mice, ACSM3 preferentially ligates C2-C6 fatty acids, especially butyrate (BUT, a C4 fatty acid) (Fujino et al. 2001). The product, butyryl-CoA (BT-CoA) is used in beta oxidation. ACSM3 gene variants may be associated with obesity-related hypertension (Iwai et al. 1994, 2002, Telgmann et al. 2007, Tikhonoff et al. 2008). The mechanisms by which ACSM3 gene variants affect blood pressure remain to be elucidated.

Mitochondrial acyl-coenzyme A synthetase ACSM6 is proposed to be located in the mitochondrial matrix and possess the same medium-chain fatty acid:CoA ligase activity as ACSM3.
Literature References
PubMed ID Title Journal Year
17278971 SAH gene variants are associated with obesity-related hypertension in Caucasians: the PEGASE Study

Drouet, L, Hasenkamp, S, Cambien, F, Brand-Herrmann, SM, Plouin, PF, Paul, M, Brink-Spalink, V, Telgmann, R, Nofer, JR, Nicaud, V, Tiret, L, Matanis, T, Schmidt-Petersen, K, Schönfelder, J, Hagedorn, C, Brand, E, Beining, K, Vischer, P

J. Hypertens. 2007
11470804 Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product

Sakai, J, Takei, YA, Kamataki, A, Takahashi, S, Fujino, T, Sone, H, Yamamoto, TT, Magoori, K, Ioka, RX

J Biol Chem 2001
18192838 SAH gene variants revisited in the European Project On Genes in Hypertension

Tikhonoff, V, Hasenkamp, S, Brand-Herrmann, SM, Nikitin, Y, Stolarz, K, Thijs, L, Filipovský, J, Kawecka-Jaszcz, K, Bäumer, V, Kuznetsova, T, Staessen, JA, Brand, E, Casiglia, E, Seidlerová, J, Peleska, J

J. Hypertens. 2008
11772874 Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension

Ogihara, T, Katsuya, T, Ogata, J, Baba, S, Higaki, J, Kokame, K, Mannami, T, Iwai, N

Circulation 2002
7907320 Human SA gene locus as a candidate locus for essential hypertension

Iwai, N, Kinoshita, M, Nakamura, Y, Hanai, K, Ohmichi, N

Hypertension 1994
Catalyst Activity

butyrate-CoA ligase activity of ACSM3,ACSM6 [mitochondrial matrix]

Inferred From
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