CBL monoubiquitinates activated MET

Stable Identifier
R-HSA-8875183
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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CBL monoubiquitinates activated MET receptor probably at multiple lysine residues, triggering MET endocytosis and degradation through the lysosomal route (Abella et al. 2005, Veiga and Cossart 2005). InlB, a cell wall protein of Listeria monocytogenes, binds to MET receptor as an HGF agonist. The subsequent CBL-mediated monoubiquitination of MET promotes endocytosis of bacteria and entry of Listeria monocytogenes into host cells (Veiga and Cossart 2005).
Literature References
PubMed ID Title Journal Year
16113677 Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells

Veiga, E, Cossart, P

Nat. Cell Biol. 2005
16227611 Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation

Peschard, P, Naujokas, MA, Abella, JV, Saucier, C, Park, M, Urbé, S, Lin, T

Mol. Cell. Biol. 2005
Participants
Participates
Catalyst Activity

ubiquitin protein ligase activity of HGF:p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:p-Y1003,4Y-MET dimer:p-Y-CBL) [plasma membrane]

Orthologous Events
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