Reactome | RAB3 GEFs exchange GTP for GDP on RAB3A

RAB3 GEFs exchange GTP for GDP on RAB3A

Stable Identifier

R-HSA-8875318

Type

Reaction [transition]

Species

Homo sapiens

Compartment

secretory granule membrane, cytosol

ReviewStatus

5/5

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RAB3A is involved in neurotransmitter release at the synaptic vesicle (Fischer et al, 1991; Holz et al, 1994; Geppert et al, 1994; Kapfhamer et al, 2002; reviewed in Pavlos and Jahn, 2011). RAB3A is activated at the synaptic vesicle through the guanine nucleotide exchange activity of RAB3IL1 (also known as GRAB) which promotes the exchange of GDP for GTP (Luo et al, 2001; Yoshimura et al, 2010). RAB3 family members are also activated by the DENN domain-containing GEF MADD, also known as RAB3GEP (Wada et al, 1997; Fukui et al, 1997; Iwasaki et al, 1997; Mahoney et al, 2006). Interaction of RAB3A with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB3A with GDI and CHM proteins.

Literature References

PubMed ID	Title	Journal	Year
9136770	aex-3 encodes a novel regulator of presynaptic activity in C. elegans Iwasaki, K, Staunton, J, Saifee, O, Nonet, M, Thomas, JH	Neuron	1997
9020086	Isolation and characterization of a GDP/GTP exchange protein specific for the Rab3 subfamily small G proteins Wada, M, Nakanishi, H, Satoh, A, Hirano, H, Obaishi, H, Matsuura, Y, Takai, Y	J. Biol. Chem.	1997
11516400	GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase Luo, HR, Saiardi, A, Nagata, E, Ye, K, Yu, H, Jung, TS, Luo, X, Jain, S, Sawa, A, Snyder, SH	Neuron	2001
21776405	Distinct yet overlapping roles of Rab GTPases on synaptic vesicles Pavlos, NJ, Jahn, R	Small GTPases	2011
8144603	Evidence for the involvement of Rab3A in Ca(2+)-dependent exocytosis from adrenal chromaffin cells Holz, RW, Brondyk, WH, Senter, RA, Kuizon, L, Macara, IG	J. Biol. Chem.	1994
20937701	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors Yoshimura, S, Gerondopoulos, A, Linford, A, Rigden, DJ, Barr, FA	J. Cell Biol.	2010
16571673	Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans Mahoney, TR, Liu, Q, Itoh, T, Luo, S, Hadwiger, G, Vincent, R, Wang, ZW, Fukuda, M, Nonet, ML	Mol. Biol. Cell	2006
7911226	The role of Rab3A in neurotransmitter release Geppert, M, Bolshakov, VY, Siegelbaum, SA, Takei, K, De Camilli, P, Hammer, RE, Südhof, TC	Nature	1994
25341920	Rab proteins and the compartmentalization of the endosomal system Wandinger-Ness, A, Zerial, M	Cold Spring Harb Perspect Biol	2014
1845915	A small GTP-binding protein dissociates from synaptic vesicles during exocytosis Fischer von Mollard, G, Südhof, TC, Jahn, R	Nature	1991
12244319	Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse Kapfhamer, D, Valladares, O, Sun, Y, Nolan, PM, Rux, JJ, Arnold, SE, Veasey, SC, Bućan, M	Nat. Genet.	2002
27246931	Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases Ishida, M, Oguchi, ME, Fukuda, M	Cell Struct. Funct.	2016