Reactome | TNS3 [cytosol]

TNS3 [cytosol]

Stable Identifier

R-HSA-8875524

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tensin-3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET interacts with TNS proteins (Homo sapiens)
        
        MET binds TNS3 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:TNS3 [plasma membrane] (Homo sapiens)
        
        TNS3 [cytosol] (Homo sapiens)
        
        TNS3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q68CZ2 TNS3

Gene Names

TNS3, TEM6, TENS1, TPP

Chain

chain:1-1445

Reference Genes

BioGPS Gene:64759 TNS3

COSMIC (genes):TNS3 TNS3

CTD Gene:64759 TNS3

dbSNP Gene:64759 TNS3

ENSEMBL:ENSG00000136205 TNS3

ENSEMBL_homo_sapiens_GENE:ENSG00000136205.18 TNS3

HGNC:21616 TNS3

KEGG Gene (Homo sapiens):64759 TNS3

Monarch:64759 TNS3

NCBI Gene:64759 TNS3

OMIM:606825 TNS3

UCSC:Q68CZ2 TNS3

Reference Transcript

Other Identifiers

11724067_a_at

11751507_a_at

11755643_a_at

17057525

217853_PM_at

217853_at

2825960

2825961

3049537

3049538

3049539

3049540

3049541

3049542

3049543

3049544

3049545

3049546

3049547

3049549

3049550

3049553

3049558

3049559

3049561

3049563

3049569

3049570

3049572

3049595

3049596

3049597

3049598

3049608

3049609

3049610

3049611

3049612

3049621

3049622

3049623

3049625

3049632

3049634

3049637

3049641

3049643

3049645

3049646

3049647

3049649

3049659

3049665

3049674

3049678

3049679

56534_at

64759

8139500

A_23_P215642

A_24_P346431

GE88430

GO:0002102

GO:0003824

GO:0004721

GO:0005515

GO:0005829

GO:0005856

GO:0005925

GO:0016311

GO:0016787

GO:0016791

GO:0042995

GO:0043226

GO:0070161

GO:0140096

HMNXSV003007994

ILMN_1667893

PH_hs_0027575

TC07001363.hg

g12232408_3p_at

Participates

as a component of

HGF:p-4Y-MET dimer:TNS3 [plasma membrane] (Homo sapiens)

as an input of

MET binds TNS3 (Homo sapiens)

Inferred To

TNS3 [cytosol] (Bos taurus)

TNS3 [cytosol] (Canis familiaris)

TNS3 [cytosol] (Gallus gallus)

TNS3 [cytosol] (Sus scrofa)

tns-1 [cytosol] (Caenorhabditis elegans)

Tns3 [cytosol] (Mus musculus)

Tns3 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_011513782.1, XP_016868028.1, XP_011513785.1, XP_011513783.1, XP_011513784.1, NP_073585.8

OpenTargets

ENSG00000136205

GeneCards

Q68CZ2

HPA

ENSG00000136205-TNS3

Ensembl

ENSP00000389285, ENSG00000136205, ENST00000311160, ENSP00000312143, ENST00000442536

PRO

Q68CZ2

Pharos - Targets

Q68CZ2

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.683	5
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.643	4
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.591	13
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.556	8
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.556	3
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.499	2

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