DOCK7 activates RAC1

Stable Identifier
R-HSA-8875591
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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DOCK7, recruited to the activated MET receptor complex through GAB1 and, possibly, CRK or CRKL, stimulates guanyl nucleotide exchange on RAC1 from GDP to GTP, resulting in RAC1 activation and HGF-stimulated cell migration/invasion (Murray et al. 2014).
Activation of RAC1 in response to HGF stimulation was reported to depend on the endosomal protein RAB5 and RAC1 guanyl exchange factor (GEF) TIAM1 (Palamidessi et al. 2008).
Literature References
PubMed ID Title Journal Year
24518591 Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation

van Aelst, L, Didier, S, Byrne, AT, Murray, DW, Paulino, V, Ruggieri, R, Tran, NL, Chan, A, Symons, M

Br. J. Cancer 2014
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane]

Orthologous Events
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