GGA3 associates with activated MET receptor

Stable Identifier
R-HSA-8875661
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, recycling endosome membrane
ReviewStatus
5/5
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GGA3 associates with activated MET receptor
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GGA3 associates with the activated MET receptor through the CRK adapter and the ARF6:GTP complex and co-localizes with the MET receptor at early endosome membranes. The mechanistic details of GGA3 recruitment to MET have not been elucidated. GGA3 promotes recycling of the activated MET receptor through a RAB4-positive endosomal compartment (Parachoniak et al. 2011).
Literature References
PubMed ID Title Journal Year
21664574 GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration

Abella, JV, Park, M, Luo, Y, Parachoniak, CA, Keen, JH

Dev. Cell 2011
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Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Birchmeier, W  (2016-07-11)
Heynen, G  (2016-07-11)
Created
Orlic-Milacic, M  (2016-06-08)
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