Reactome | SLC50A1 transports Glc from cytosol to extracellular region

SLC50A1 transports Glc from cytosol to extracellular region

Stable Identifier

R-HSA-8876319

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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SLC50A1 transports Glc from cytosol to extracellular region

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In mammals, glucose efflux from the liver is crucial for the maintenance of blood glucose levels (Deng & Yan 2016). Human sugar transporter SWEET1 (SLC50A1) is a ubiquitously expressed transport protein, with highest expression in oviduct, epididymis and intestine. It localises to the Golgi membrane where it may supply glucose to the Golgi for secretion from intestinal and liver cells (Chen et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
26650681	GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters Deng, D, Yan, N	Protein Sci.	2016
21107422	Sugar transporters for intercellular exchange and nutrition of pathogens Underwood, W, Somerville, SC, White, FF, Kim, JG, Lalonde, S, Guo, WJ, Qu, XQ, Chaudhuri, B, Takanaga, H, Frommer, WB, Chermak, D, Mudgett, MB, Antony, G, Hartung, ML, Hou, BH, Chen, LQ	Nature	2010