Reactome | CHOL translocates from lysosome membrane to ER membrane

CHOL translocates from lysosome membrane to ER membrane

Stable Identifier

R-HSA-8876485

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, lysosomal membrane

ReviewStatus

5/5

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CHOL translocates from lysosome membrane to ER membrane

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In macrophages, the hydrolysis of cholesteryl esters (CHESTs) is the rate-limiting step in the removal of free cholesterol (CHOL) from these cells. CHOL is transported via transport vesicles and can be used for cellular functions or removed from the cell by ABCA1 to create new HDL particles. Accumulation of CHESTs in macrophage foam cells is key to atherosclerotic plaque formation (Dubland & Francis 2015). CHOL is positioned on the outer membrane of lysosomes and translocates to the ER membrane where it can be re-esterified for storage. The mechanism of translocation is currently unknown (Infante et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
25699256	Lysosomal acid lipase: at the crossroads of normal and atherogenic cholesterol metabolism Dubland, JA, Francis, GA	Front Cell Dev Biol	2015
18772377	NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes Infante, RE, Wang, ML, Radhakrishnan, A, Kwon, HJ, Brown, MS, Goldstein, JL	Proc. Natl. Acad. Sci. U.S.A.	2008