DENND6A,B exchange GTP for GDP on RAB14

Stable Identifier
Reaction [transition]
Homo sapiens
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RAB14 is involved in the trafficking of GLUT4 to the plasma membrane and also contributes to cell migration by regulating the trafficking of ADAM10, a metalloendopetidase that cleaves a number of cell surface proteins including the adherens junction components N-cadherin (Reed et al, 2013; Brewer et al, 2016; Linford et al, 2012; Lu et al, 2012; Maretzky et al, 2005; Reiss et al, 2005; Gutwein et al, 2010; Rabquer et al, 2010). DENND6A and B, also known as FAM116A and B, show RAB14 GEF activity in vitro and are required for RAB14 localization and activity in vivo (Linford et al, 2012; reviewed in Ishida et al, 2016). Interaction of RAB14:GDP with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB14 with GDI and CHM proteins.

Literature References
PubMed ID Title Journal Year
26936971 Rab14 limits the sorting of Glut4 from endosomes into insulin-sensitive regulated secretory compartments in adipocytes

Brewer, PD, Mastick, CC, Coster, AC, Romenskaia, I, Habtemichael, EN

Biochem. J. 2016
23444368 A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes

McCaffrey, MW, Kelly, EE, Verkade, P, Song, S, Hodgson, LR, Reed, SE, May, MT, Tavaré, JM, Mastick, CC

J. Cell. Sci. 2013
15692570 ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

Hartmann, D, Maretzky, T, De Strooper, B, Tousseyn, T, Ludwig, A, Saftig, P, Reiss, K

EMBO J. 2005
12475894 ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles

Mechtersheimer, S, Gutwein, P, Zentgraf, H, Gast, D, Joumaa, S, Altevogt, DP, Riedle, S, Stoeck, A, Fogel, M

FASEB J. 2003
20592283 Junctional adhesion molecule-C is a soluble mediator of angiogenesis

Ruth, JH, Imhof, BA, Teegala, N, Amin, MA, Shaheen, MK, Rabquer, BJ, Koch, AE, Tsou, PS, Lesch, CA

J. Immunol. 2010
15958533 ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation

Hartmann, D, Proksch, E, Scholz, F, Buchholz, J, Maretzky, T, De Strooper, B, Ludwig, A, Saftig, P, Reiss, K

Proc. Natl. Acad. Sci. U.S.A. 2005
25341920 Rab proteins and the compartmentalization of the endosomal system

Wandinger-Ness, A, Zerial, M

Cold Spring Harb Perspect Biol 2014
24694596 Rab14 regulation of claudin-2 trafficking modulates epithelial permeability and lumen morphogenesis

Stewart, L, Lu, R, Elliott, D, Wilson, JM, Johnson, DL, Waite, K

Mol. Biol. Cell 2014
27246931 Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases

Oguchi, ME, Fukuda, M, Ishida, M

Cell Struct. Funct. 2016
22595670 Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells

Linford, A, Rigden, DJ, Barr, FA, Gerondopoulos, A, Yoshimura, S, Langemeyer, L, Nunes Bastos, R

Dev. Cell 2012
Catalyst Activity

guanyl-nucleotide exchange factor activity of DENND6A,B [cytosol]

Orthologous Events
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