SRC phosphorylates InlA-bound CDH1 and CTNNB1

Stable Identifier
R-HSA-8876948
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Listeria monocytogenes
Compartment
plasma membrane, peptidoglycan-based cell wall, cytosol
ReviewStatus
5/5
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SRC phosphorylates InlA-bound CDH1 and CTNNB1
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SRC-mediated phosphorylation of E-cadherin (CDH1) is needed for InlA-mediated entry of Listeria monocytogenes into host cells (Bonazzi et al. 2008). At cell adhesion sites, SRC is known to phosphorylate CDH1 at tyrosine residues Y753 and Y754 and CDH1-bound beta-catenin (CTNNB1) at an unknown tyrosine residue. SRC-phosphorylated tyrosines of CDH1 and CTNNB1 serve as docking sites for the E3 ubiquitin ligase Hakai (CBLL1) (Fujita et al. 2002, Mukherjee et al. 2012).
Literature References
PubMed ID Title Journal Year
18624796 Successive post-translational modifications of E-cadherin are required for InlA-mediated internalization of Listeria monocytogenes

Pizarro-Cerdá, J, Bonazzi, M, Veiga, E, Cossart, P

Cell. Microbiol. 2008
Participants
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Output
Entity On Other Cell
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as an event of
Catalyst Activity

protein tyrosine kinase activity of MyrG-p-Y419-SRC [plasma membrane]

Physical Entity
MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Disease
Name Identifier Synonyms
listeriosis DOID:11573 Infection by Listeria monocytogenes, Infection due to Listeria monocytogenes, Listeria infection, Listeriosis
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Schwerk, C  (2016-10-25)
Created
Orlic-Milacic, M  (2016-06-17)
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