Reactome | PTPN4 [cytosol]

PTPN4 [cytosol]

Stable Identifier

R-HSA-8877173

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein phosphatase non-receptor type 4, Protein-tyrosine phosphatase MEG1, MEG, PTPase-MEG1, PTN4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P29074 PTPN4

Gene Names

PTPN4

Chain

chain:1-926

Reference Genes

BioGPS Gene:5775 PTPN4

COSMIC (genes):PTPN4 PTPN4

CTD Gene:5775 PTPN4

dbSNP Gene:5775 PTPN4

ENSEMBL:ENSG00000088179 PTPN4

HGNC:9656 PTPN4

KEGG:hsa:5775 PTPN4

Monarch:5775 PTPN4

NCBI Gene:5775 PTPN4

OMIM:176878 PTPN4

UCSC:P29074 PTPN4

Reference Transcript

Other Identifiers

11741358_a_at

1459_at

1460_g_at

16885041

205171_PM_at

205171_at

230230_PM_at

230230_at

232161_3p_x_at

232161_PM_x_at

232161_x_at

236935_PM_at

236935_at

2503022

2503023

2503024

2503025

2503026

2503027

2503028

2503029

2503030

2503038

2503042

2503045

2503046

2503049

2503050

2503051

2503052

2503059

2503065

2503066

2503068

2503070

2503071

2503072

2503073

2503075

2503076

2503077

2503078

2503080

2503081

2503082

2503083

2503084

2503085

2503086

2503088

2503089

2503092

2503093

2503097

2503099

2503100

2503101

2503102

2503103

2503104

2503106

2503108

42078_at

45455_at

47847_at

5775

70407_at

75626_at

8044849

A_23_P165343

A_24_P122940

A_32_P183983

A_32_P96845

A_33_P3265920

GE532907

GE58049

GE87878

GO:0003824

GO:0004721

GO:0004725

GO:0004726

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006470

GO:0008092

GO:0009898

GO:0016020

GO:0016311

GO:0016787

GO:0035254

GO:0043226

GO:0140096

HMNXSV003016275

Hs.145934.0.A1_3p_at

Hs.26743.0.A1_3p_at

Hs.71592.0.S1_3p_at

Hs.71592.0.S1_3p_x_at

ILMN_1793549

M68941_at

PH_hs_0023771

TC02000756.hg

TC02003533.hg

g4506294_3p_at

Participates

as an output of

PTPN4 gene expression is stimulated by MECP2 (Homo sapiens)

This entity regulates

Negatively

Endocytosis of TRAM (TICAM2) (Homo sapiens)

Other forms of this molecule

PTPN4 [nucleoplasm]

Inferred To

PTPN4 [cytosol] (Bos taurus)

PTPN4 [cytosol] (Canis familiaris)

PTPN4 [cytosol] (Danio rerio)

PTPN4 [cytosol] (Mus musculus)

PTPN4 [cytosol] (Rattus norvegicus)

PTPN4 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_016860089.1, NP_002821.1

ENSEMBL

ENSP00000263708, ENST00000263708

OpenTargets

ENSG00000088179

IntEnz

3.1.3.48

HPA

ENSG00000088179-PTPN4

PRO

P29074

Pharos - Targets

P29074

HMDB Protein

HMDBP08936

PDB

7VZE, 2I75, 3NFL, 5EZ0, 5EYZ, 2VPH, 2CS5, 3NFK

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-15948124 GLUN2A16			0.558	2
IntAct:EBI-15948079 CYTO			0.558	2
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.543	3
UniProt:Q5T2T1 MPP7	1	MPP7 [plasma membrane] (R-HSA-9714466)	0.527	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:Q9BY67 CADM1	1	CADM1 [plasma membrane] (R-HSA-420589)	0.527	2
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.508	2