Reactome | TRAPPC complexes exchange GTP for GDP on RAB1

TRAPPC complexes exchange GTP for GDP on RAB1

Stable Identifier

R-HSA-8877475

Type

Reaction [transition]

Species

Homo sapiens

Compartment

transport vesicle membrane, cytosol

ReviewStatus

5/5

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TRAPPC complexes exchange GTP for GDP on RAB1

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RAB1 is involved in COPII-mediated anterograde traffic from the endoplasmic reticulum to the ERGIC (ER-Golgi intermediate compartment) and in early steps of the macroautophagy pathway (reviewed in Szul and Sztul, 2011; Sandoval and Simmen, 2012; Lord et al, 2013; Yang et al, 2016; Lamb et al, 2016; Kim et al, 2016; Ao et al, 2014). RAB1 nucleotide exchange is stimulated in these pathways by the GEF activity of the multisubunit TRAPPC complexes II and III, respectively (reviewed in Brunet and Sacher, 2014; Kim et al, 2016). Note that the separate existence of a TRAPPCI complex is not clearly established in human cells (Barrowman et al, 2010; Bassik et al, 2013; reviewed in Brunet and Sacher, 2014; Kim et al, 2016). TRAPPCII is recruited to ER-derived vesicles by virtue of an interaction between the TRAPPCII component TRAPPC3 and the COPII coat protein SEC23 (Wang et al, 2000; Cai et al, 2007; Cai et al, 2008; Yamasaki et al, 2009; Lord et al, 2011; reviewed in Brunet and Sacher, 2014; Ishida et al, 2016). Interaction of TRAAPPCII with RAB1:GDP promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB1 with GDI and CHM proteins. Protein protein interactions involving activated RAB1:GTP help dock the ER-derived vesicle on the cis-Golgi membrane (reviewed in Lord et al, 2013). In the macroautophagy pathway, RAB1 and the TRAPPCIII complex play a role in the formation of the pre-autophagosomal structure (PAS) and contribute to the localization of ATG9, a key nucleator of autophagosome formation (Lynch-Day et al, 2010; Winslow et al, 2010; Zoppino et al, 2010; Mochizuki et al, 2013; Lamb et al, 2016; reviewed in Kim et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
19656848	mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles Klumperman, J, Oorschot, V, Ferro-Novick, S, Yu, S, Yamasaki, A, Meerloo, T, Menon, S, Satoh, A, Barrowman, J	Mol. Biol. Cell	2009
17287728	TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 Fu, C, Ferro-Novick, S, Yu, S, Cai, H, Menon, S, Lazarova, D, Cai, Y, Hay, JC, Reinisch, K	Nature	2007
22013193	COPII and COPI traffic at the ER-Golgi interface Sztul, E, Szul, T	Physiology (Bethesda)	2011
23176493	Rab proteins of the endoplasmic reticulum: functions and interactors Simmen, T, Ortiz Sandoval, C	Biochem. Soc. Trans.	2012
23378591	The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi Ferro-Novick, S, Miller, EA, Lord, C	Cold Spring Harb Perspect Biol	2013
25341920	Rab proteins and the compartmentalization of the endosomal system Wandinger-Ness, A, Zerial, M	Cold Spring Harb Perspect Biol	2014
11038176	TRAPP stimulates guanine nucleotide exchange on Ypt1p Wang, W, Ferro-Novick, S, Sacher, M	J. Cell Biol.	2000
24917561	In sickness and in health: the role of TRAPP and associated proteins in disease Sacher, M, Brunet, S	Traffic	2014
18585354	The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes Sclafani, A, Fu, C, Ferro-Novick, S, Reinisch, KM, Cai, H, Menon, S, Lazarova, D, De La Cruz, EM, Cai, Y, Chin, HF, Rodgers, DW	Cell	2008
21532587	Sequential interactions with Sec23 control the direction of vesicle traffic Ghassemian, M, Ghosh, P, Bhandari, D, Ferro-Novick, S, Menon, S, Nycz, D, Lord, C, Hay, J	Nature	2011
27246931	Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases Oguchi, ME, Fukuda, M, Ishida, M	Cell Struct. Funct.	2016
27041585	Rab1 in cell signaling, cancer and other diseases Li, XX, Zhang, YJ, Zheng, XF, Rodriguez-Rodriguez, L, Xiang, MQ, Wang, HY, Yang, XZ	Oncogene	2016