Reactome | DENND1s exchange GTP for GDP on RAB35

DENND1s exchange GTP for GDP on RAB35

Stable Identifier

R-HSA-8877612

Type

Reaction [transition]

Species

Homo sapiens

Compartment

recycling endosome membrane, cytosol

ReviewStatus

5/5

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RAB35 localizes to the plasma membrane, to clathrin-coated vesicles and to the endosome where it plays roles in recycling of endocytic cargo to the plasma membrane, in synaptic vesicle recycling and fusion of exosomes. RAB35 is also required for cytokinesis and contributes to the regulation of the actin cytoskeleton, and for GLUT4 translocation to the plasma membrane in response to insulin (Fuchs et al, 2007; Allaire et al, 2010; Kouranti et al, 2006; Dambournet et al, 2011; Rahajeng et al, 2012; Hsu et al. 2010; Uytterhoeven et al. 2011; Zhang et al. 2009; Davey et al, 2012; Humphrey et al, 2013; reviewed in Klinkert and Echard, 2016). RAB35 is activated by DENND1A, B and C (Sato et al, 2008; Allaire et al, 2010; Yoshimura et al, 2010; Marat and McPherson, 2010; Marat et al, 2012; reviewed in Marat et al, 2011; Ishida et al, 2016). Interaction of RAB35:GDP with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB35 with GDI and CHM proteins (Wu et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
19729655	Rab35 controls actin bundling by recruiting fascin as an effector protein Suyama, K, Zhang, J, Bogyo, M, Scott, MP, Fonovic, M	Science	2009
16950109	Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis Arouche, N, Goud, B, Sachse, M, Kouranti, I, Echard, A	Curr. Biol.	2006
21458671	Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins Miskiewicz, K, Kuenen, S, Verstreken, P, Kasprowicz, J, Uytterhoeven, V	Cell	2011
20937701	Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors Linford, A, Rigden, DJ, Barr, FA, Gerondopoulos, A, Yoshimura, S	J. Cell Biol.	2010
21330364	DENN domain proteins: regulators of Rab GTPases Dokainish, H, Marat, AL, McPherson, PS	J. Biol. Chem.	2011
22072793	Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton Marat, AL, Ioannou, MS, McPherson, PS	Mol. Biol. Cell	2012
27329675	Rab35 GTPase: a central regulator of phosphoinositides and F-actin in endocytic recycling and beyond Klinkert, K, Echard, A	Traffic	2016
18354496	Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein Sato, K, Grant, BD, Sato, M, Liou, W, Pant, S, Harada, A	EMBO J.	2008
23684622	Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2 James, DE, Yang, G, Stöckli, J, Fazakerley, DJ, Yang, P, Yang, JY, Humphrey, SJ	Cell Metab.	2013
20159556	The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes Ritter, B, Marat, AL, Allaire, PD, Di Paolo, G, Dall'Armi, C, McPherson, PS	Mol. Cell	2010
20404108	Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C Lauterbach, MA, Manrique-Hoyos, N, Barr, FA, Simons, M, Hsu, C, Jung, S, Morohashi, Y, Bakhti, M, Yoshimura, S, Rhee, J, Möbius, W, Grønborg, M	J. Cell Biol.	2010
20154091	The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery Marat, AL, McPherson, PS	J. Biol. Chem.	2010
17562788	Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways Spooner, RA, Barr, FA, Lord, JM, Haas, AK, Yoshimura, S, Fuchs, E	J. Cell Biol.	2007
22065758	Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate Reinisch, KM, Barr, FA, Kümmel, D, De La Cruz, EM, Cai, Y, Bradley, MJ, Wu, X	Proc. Natl. Acad. Sci. U.S.A.	2011
21706022	Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis Salomon, R, Dambournet, D, El Marjou, A, Rocancourt, M, Formstecher, E, Machicoane, M, Chesneau, L, Goud, B, Sachse, M, Echard, A	Nat. Cell Biol.	2011
22762500	TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes Stöckli, J, James, DE, Davey, JR, Lambright, DG, Mishra, AK, Junutula, JR, Humphrey, SJ	Traffic	2012
21951725	MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a Giridharan, SS, Rahajeng, J, Cai, B, Naslavsky, N, Caplan, S	Traffic	2012
27246931	Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases Oguchi, ME, Fukuda, M, Ishida, M	Cell Struct. Funct.	2016