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PIN1 binds phosphorylated PIP4K2B
Stable Identifier
R-HSA-8877692
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Acetylation (Homo sapiens)
PI5P Regulates TP53 Acetylation (Homo sapiens)
PIN1 binds phosphorylated PIP4K2B (Homo sapiens)
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Peptidyl-prolyl cis-trans isomerase PIN1 binds to PIP4K2B phosphorylated at serine residue S326. PIP4K2B is phosphorylated at S326 under conditions of cellular stress, such as increased level of reactive oxygen species (ROS). Phosphorylation of PIP4K2B at threonine residue T322 may also contribute to PIN1 binding. PIN1 induces conformational change of PIP4K2B, resulting in inactivation of PIP4K2B dimers. This enables increase of the nuclear PI5P levels. PI5P positively regulates expression of genes involved in neutralization of ROS (Keune et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
23193159
Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress
Zhou, XZ
,
Sommer, L
,
Lu, KP
,
Jones, DR
,
Bultsma, Y
,
Keune, WJ
,
Divecha, N
Sci Signal
2012
Participants
Input
p-S326-PIP4K2B dimers [nucleoplasm]
(Homo sapiens)
PIN1 [nucleoplasm]
(Homo sapiens)
Output
p-S326-PIP4K2B dimers:PIN1 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
PI5P Regulates TP53 Acetylation (Homo sapiens)
Orthologous Events
PIN1 binds phosphorylated PIP4K2B (Bos taurus)
PIN1 binds phosphorylated PIP4K2B (Caenorhabditis elegans)
PIN1 binds phosphorylated PIP4K2B (Canis familiaris)
PIN1 binds phosphorylated PIP4K2B (Dictyostelium discoideum)
PIN1 binds phosphorylated PIP4K2B (Drosophila melanogaster)
PIN1 binds phosphorylated PIP4K2B (Gallus gallus)
PIN1 binds phosphorylated PIP4K2B (Mus musculus)
PIN1 binds phosphorylated PIP4K2B (Rattus norvegicus)
PIN1 binds phosphorylated PIP4K2B (Saccharomyces cerevisiae)
PIN1 binds phosphorylated PIP4K2B (Schizosaccharomyces pombe)
PIN1 binds phosphorylated PIP4K2B (Sus scrofa)
PIN1 binds phosphorylated PIP4K2B (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2016-06-28)
Reviewed
Divecha, N (2016-06-21)
Created
Orlic-Milacic, M (2016-06-28)
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