HIPK2 phosphorylates RUNX1

Stable Identifier
R-HSA-8878054
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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HIPK2 phosphorylates RUNX1
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Protein serine/threonine kinase HIPK2 phosphorylates RUNX1 upon formation of the RUNX1:CBFB complex. Serine residues S249 and S273 and threonine residue S276 of RUNX1 are phosphorylated by HIPK2. HIPK2-mediated phosphorylation of RUNX1 is implicated as an important regulatory step in hematopoiesis and is disrupted by leukemogenic mutations in CBFB (Aikawa et al. 2006, Wee et al. 2008).
Literature References
PubMed ID Title Journal Year
18695000 PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

Ito, Y, Voon, DC, Wee, HJ, Bae, SC

Blood 2008
16917507 Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

Koseki, H, Schmitz, ML, Nguyen, LA, Takakura, N, Isono, K, Tagata, Y, Kitabayashi, I, Aikawa, Y

EMBO J. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of HIPK2 [nucleoplasm]

Physical Entity
HIPK2 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
HIPK2 phosphorylates RUNX1 (Bos taurus)
HIPK2 phosphorylates RUNX1 (Caenorhabditis elegans)
HIPK2 phosphorylates RUNX1 (Canis familiaris)
HIPK2 phosphorylates RUNX1 (Drosophila melanogaster)
HIPK2 phosphorylates RUNX1 (Gallus gallus)
HIPK2 phosphorylates RUNX1 (Mus musculus)
HIPK2 phosphorylates RUNX1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-06-29)
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