HES1 gene transcription is inhibited by RUNX3

Stable Identifier
R-HSA-8878243
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of RUNX3 to the NOTCH1 coactivator complex at the HES1 gene promoter results in repression of HES1 transcription downstream of NOTCH1 signaling (Gao et al. 2010).
Literature References
PubMed ID Title Journal Year
19800882 RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells

Gao, J, Chen, Y, Du, R, Zhao, YQ, Xu, HL, Fan, DM, Liu, J, Wu, KC, Pan, YL, Zheng, GR, Xiong, YM

Exp. Cell Res. 2010
Participants
Participates
This event is regulated
Authored
Reviewed
Created
Cite Us!