SSC5D binds ligands

Stable Identifier
R-HSA-8878603
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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SSC5D binds ligands
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SSC5D is a secreted member of group B of the SRCR superfamily. Human SSC5D binds surfaces of whole bacteria and is able to discriminate pathogenic strains from non-pathogenic strains (Bessa Pereira et al. 2016). Mouse Ssc5d (S5D-SRCRB) binds bacterial surface polymers (peptidoglycan, lipopolysaccharide), yeast surface polymers (beta-glucan), and glycoproteins (Galectin-1, Galectin-3, Laminin). Human SSC5D may bind similar ligands but this has not yet been demonstrated. Mouse Ssc5d is expressed in the urogenital tract (Miró-Julià et al. 2014).
Literature References
PubMed ID Title Journal Year
27790215 The Scavenger Receptor SSc5D Physically Interacts with Bacteria through the SRCR-Containing N-Terminal Domain

Bessa Pereira, C, Bocková, M, Santos, AM, Carmo, AM, Homola, J, Santos, RF, Martins de Araújo, M, Oliveira, L

Front Immunol 2016
Participants
Input
Output
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as an event of
Inferred From
Ssc5d binds ligands (Mus musculus)
Authored
May, B  (2016-07-11)
Reviewed
Lozano, F  (2017-02-11)
Carmo, AM  (2017-02-11)
Created
May, B  (2016-07-12)
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