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PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
Stable Identifier
R-HSA-888582
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
Synonyms
Glutamate decarboxylase 2, DCE2_HUMAN, GAD65
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates transcription of genes involved in GABA signaling (Homo sapiens)
GAD2 gene expression is stimulated by MECP2 (Homo sapiens)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
GABA synthesis, release, reuptake and degradation (Homo sapiens)
GABA loaded synaptic vesicle Docking and Priming (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
GABA Loaded synaptic vesicle [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-GAD dimers [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-GAD1:PXLP-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 dimer [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
GABA Loaded synaptic vesicle [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-GAD dimers [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-GAD1:PXLP-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 dimer [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
GABA synthesis (Homo sapiens)
Synthesis of GABA by GAD2 (Homo sapiens)
PXLP-GAD dimers [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-GAD1:PXLP-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 dimer [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
Release of GABA at the synapse (Homo sapiens)
Docked GABA loaded synaptic vesicle [cytosol] (Homo sapiens)
GABA Loaded synaptic vesicle [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-GAD dimers [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-GAD1:PXLP-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 dimer [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
General
GAD65 or GAD2 is concentrated in the nerve terminal region in the neurons and is involved in the synthesis of GABA which is used as a neurotransmitter.
External Reference Information
External Reference
UniProt:Q05329 GAD2
Gene Names
GAD2, GAD65
Chain
chain:1-585
Reference Genes
BioGPS Gene:2572 GAD2
COSMIC (genes):GAD2 GAD2
CTD Gene:2572 GAD2
dbSNP Gene:2572 GAD2
ENSEMBL:ENSG00000136750 GAD2
HGNC:4093 GAD2
KEGG:hsa:2572 GAD2
Monarch:2572 GAD2
NCBI Gene:2572 GAD2
OMIM:138275 GAD2
UCSC:Q05329 GAD2
Reference Transcript
RefSeq:NM_001134366.1 GAD2
RefSeq:NM_000818.2 GAD2
Other Identifiers
11730977_a_at
11730978_a_at
11737613_a_at
16703382
206780_PM_at
206780_at
211264_PM_at
211264_at
216651_PM_s_at
216651_s_at
2572
32279_at
32280_at
3239678
3239679
3239680
3239681
3239682
3239683
3239684
3239686
3239687
3239688
3239690
3239691
3239692
3239693
3239694
3239695
3239701
3239712
3239713
3239714
3239721
3239722
3239723
3239725
3239726
3239727
3239728
3239729
3239730
3239731
3239732
3239733
3239734
3239736
7926766
A_14_P107931
A_23_P75008
A_33_P3332369
A_33_P3420530
GE58074
GO:0000139
GO:0003824
GO:0004351
GO:0005515
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0006520
GO:0006540
GO:0006950
GO:0007268
GO:0009410
GO:0009449
GO:0016595
GO:0016829
GO:0016830
GO:0016831
GO:0019752
GO:0023052
GO:0030170
GO:0030424
GO:0030672
GO:0031410
GO:0031982
GO:0032570
GO:0042220
GO:0042734
GO:0042995
GO:0043025
GO:0043226
GO:0044877
GO:0045202
GO:0048471
GO:0060077
GO:0061202
GO:0061771
GO:0071456
GO:0071548
GO:0098793
GO:0098982
GO:1990416
HMNXSV003017356
HMNXSV003056230
Hs.170808.2.S1_3p_a_at
Hs2.170808.3.S1_3p_at
Hs2.170808.3.S1_3p_s_at
ILMN_1728301
M74826_at
M81882_at
PH_hs_0023154
TC10000180.hg
g182933_3p_at
g4503874_3p_at
Participates
as an output of
GAD2 gene expression is stimulated by MECP2 (Homo sapiens)
as a component of
PXLP-GAD1:PXLP-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
PXLP-K396-GAD2 dimer [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (Homo sapiens)
Other forms of this molecule
PXLP-K396-GAD2 [plasma membrane]
Inferred To
gad2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Xenopus tropicalis)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Canis familiaris)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Drosophila melanogaster)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Gallus gallus)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Mus musculus)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Rattus norvegicus)
PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Sus scrofa)
GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Bos taurus)
GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Sus scrofa)
unc-25 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Caenorhabditis elegans)
Homologues of PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(Sus scrofa)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 396
Coordinate
396
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
NP_001127838.1
,
NP_000809.1
Guide to Pharmacology - Targets
1273
OpenTargets
ENSG00000136750
ENSEMBL
ENSP00000259271
,
ENSP00000365437
,
ENST00000376261
,
ENST00000259271
IntEnz
4.1.1.15
HPA
ENSG00000136750-GAD2
PRO
Q05329
Pharos - Targets
Q05329
HMDB Protein
HMDBP00702
PDB
1ES0
,
2OKK
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96B96 LDAF1
0.718
6
UniProt:Q969L2 MAL2
0.718
6
UniProt:Q15041 AR6P1
0.718
6
UniProt:Q6ZWK4 RHEX
0.556
3
UniProt:Q8N8Q1 C56D1
0.556
3
UniProt:O43761 SNG3
0.556
3
UniProt:Q9HC36 MRM3
1
RNMTL1 [mitochondrial matrix]
(R-HSA-6793067)
0.556
3
UniProt:Q6E0U4 DMKN
1
DMKN [secretory granule lumen]
(R-HSA-9839542)
0.556
3
UniProt:P55056 APOC4
1
APOC4 [extracellular region]
(R-HSA-5215930)
0.556
3
UniProt:O60664 PLIN3
7
p-PLIN3 [lysosomal lumen]
(R-HSA-9639396)
p-PLIN3 [cytosol]
(R-HSA-9613664)
p-PLIN3 [lipid droplet]
(R-HSA-9613539)
PLIN3 [lipid droplet]
(R-HSA-9613337)
p-PLIN3 [late endosome lumen]
(R-HSA-9639393)
PLIN3 [cytosol]
(R-HSA-6814628)
PLIN3 [transport vesicle]
(R-HSA-6813900)
0.556
3
UniProt:Q5BJH2-2 TMEM128
0.556
3
UniProt:Q96DZ9 CKLF5
0.556
3
UniProt:Q96AL5 Q96AL5
0.556
3
UniProt:Q7Z7G2 CPLX4
0.556
3
UniProt:O60906 SMPD2
1
SMPD2 [plasma membrane]
(R-HSA-194337)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:Q5T9G4-2 ARMC12
0.556
3
UniProt:Q86UF1 TSPAN33
2
TSPAN33 [plasma membrane]
(R-HSA-9010024)
TSPAN33 [endoplasmic reticulum lumen]
(R-HSA-9010054)
0.556
3
UniProt:Q8WTS1 ABHD5
2
ABHD5 [lipid droplet]
(R-HSA-163485)
ABHD5 [cytosol]
(R-HSA-163531)
0.556
3
UniProt:Q8N3Y7 SDR16C5
1
RDHE2 [endoplasmic reticulum membrane]
(R-HSA-5621649)
0.556
3
UniProt:Q9H400 LIME1
0.556
3
UniProt:Q96DZ9-2 CMTM5
0.556
3
UniProt:Q6RW13-2 AGTRAP
0.556
3
UniProt:Q8IZV5 RDH10
1
RDH10 [endoplasmic reticulum membrane]
(R-HSA-2454090)
0.556
3
UniProt:Q9UBN6 TNFRSF10D
1
TNFRSF10D [plasma membrane]
(R-HSA-5633374)
0.556
3
UniProt:Q9BUN8 DERL1
1
DERL1 [endoplasmic reticulum membrane]
(R-HSA-6781898)
0.556
3
UniProt:Q5EB52 MEST
0.556
3
UniProt:Q9NS64 RPRM
0.556
3
UniProt:O15126 SCAMP1
2
SCAMP1 [plasma membrane]
(R-HSA-6806161)
SCAMP1 [specific granule membrane]
(R-HSA-6806140)
0.556
3
UniProt:Q96IW7 SEC22A
3
SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688562)
SEC22A [ER to Golgi transport vesicle membrane]
(R-HSA-5688560)
SEC22A [endoplasmic reticulum membrane]
(R-HSA-5216111)
0.556
3
UniProt:Q9NZD8 SPG21
0.556
3
UniProt:Q9NRY5 FAM114A2
2
FAM114A2(1-327)-p-BRAF(439-766) fusion [cytosol]
(R-HSA-6802525)
FAM114A2(1-327)-BRAF(439-766) fusion [cytosol]
(R-HSA-6802321)
0.556
3
UniProt:Q96Q80 DERL3
1
DERL3 [endoplasmic reticulum membrane]
(R-HSA-8866516)
0.556
3
UniProt:Q06432 CCG1
0.556
3
UniProt:Q8N9I5 FADS6
0.556
3
UniProt:Q96GL9 F163A
0.556
3
UniProt:Q6PIF2 SYCE2
1
SYCE2 [nucleoplasm]
(R-HSA-912451)
0.556
3
UniProt:Q8WZ55 BSND
1
BSND [plasma membrane]
(R-HSA-2854996)
0.556
3
UniProt:A0PK00 T120B
0.556
3
UniProt:Q6ZPD8 DGAT2L6
1
DGAT2L6 [endoplasmic reticulum membrane]
(R-HSA-8848588)
0.556
3
UniProt:Q6RW13 AGTRAP
2
AGTRAP(1-159)-BRAF(288-545) fusion [cytosol]
(R-HSA-6802262)
AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol]
(R-HSA-6802511)
0.556
3
UniProt:A8MV81 HIGD1C
1
HIGD1C [mitochondrial inner membrane]
(R-HSA-9865734)
0.556
3
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