Reactome | GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]

GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8931656

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

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Locations in the PathwayBrowser for interactor UniProt:Q8WXA8 HTR3C

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External Reference Information

External Reference

UniProt:Q14118 DAG1

Gene Names

DAG1

Chain

signal peptide:1-29, chain:30-653, chain:654-895

Reference Genes

BioGPS Gene:1605 DAG1

COSMIC (genes):DAG1 DAG1

CTD Gene:1605 DAG1

dbSNP Gene:1605 DAG1

ENSEMBL:ENSG00000173402 DAG1

HGNC:2666 DAG1

KEGG:hsa:1605 DAG1

Monarch:1605 DAG1

NCBI Gene:1605 DAG1

OMIM:128239 DAG1

UCSC:Q14118 DAG1

Reference Transcript

Participates

as an output of

B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1 (Homo sapiens)

as an input of

POMK 6-phosphorylates mannose in GalNAc-GlcNAc-Man-DAG1 (Homo sapiens)

Other forms of this molecule

DAG1(654-895) [plasma membrane]

DAG1(30-653) [extracellular region]

DAG1(30-653) [cytosol]

DAG1(30-653) [endoplasmic reticulum lumen]

Man-DAG1 [endoplasmic reticulum lumen]

DAG1 [endoplasmic reticulum membrane]

DAG1(654-895) [endoplasmic reticulum membrane]

Core M1,3-DAG1 [Golgi lumen]

Core M1,2,3-DAG1 [Golgi lumen]

Core M3-DAG1 [Golgi lumen]

GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen]

GlcNAc-Man-DAG1 [endoplasmic reticulum lumen]

RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]

Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]

RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]

GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]

Xyl-GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen]

Matriglycan-DAG1 [Golgi lumen]

3S-Matriglycan-DAG1 [Golgi lumen]

Man-DAG1 [Golgi lumen]

GlcNAc-1,6-(GlcNAc-1,2)-Man-DAG1 [extracellular region]

DAG1(654-895) [Golgi membrane]

Inferred To

DAG1 [endoplasmic reticulum lumen] (Bos taurus)

DAG1 [endoplasmic reticulum lumen] (Canis familiaris)

DAG1 [endoplasmic reticulum lumen] (Gallus gallus)

DAG1 [endoplasmic reticulum lumen] (Sus scrofa)

Dag1 [endoplasmic reticulum lumen] (Mus musculus)

Dag1 [endoplasmic reticulum lumen] (Rattus norvegicus)

Dg [endoplasmic reticulum lumen] (Drosophila melanogaster)

dgn-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

dag1 [endoplasmic reticulum lumen] (Danio rerio)

dag1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

Modified Residues

Name

O-mannosyl-L-threonine (N-acetyl-β-D-galactosaminyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→4)-α-D-mannosyl-L-threonine residue) at 367

Coordinate

367

Modification

N-acetyl-β-D-galactosaminyl-(1→3)-N-acetyl-β-D-glucosaminyl-(1→4)-α-D-mannosyl-L-threonine residue

PsiMod Name

O-mannosyl-L-threonine

PsiMod Definition

a protein modification that effectively forms a O3-mannosylthreonine

Name

O-mannosyl-L-threonine (O-(α-D-mannosyl)-L-threonine residue) at 423

Coordinate

423

Modification

O-(α-D-mannosyl)-L-threonine residue

PsiMod Name

O-mannosyl-L-threonine

PsiMod Definition

a protein modification that effectively forms a O3-mannosylthreonine

Name

O-mannosyl-L-threonine (O-(α-D-mannosyl)-L-threonine residue) at 481

Coordinate

481

Modification

O-(α-D-mannosyl)-L-threonine residue

PsiMod Name

O-mannosyl-L-threonine

PsiMod Definition

a protein modification that effectively forms a O3-mannosylthreonine

Cross References

RefSeq

XP_047303514.1, NP_001171114.2, XP_047303516.1, NP_001171108.2, NP_001171112.2, XP_047303534.1, XP_047303495.1, NP_001171106.2, XP_047303508.1, XP_047303506.1, NP_001159400.3, XP_047303529.1, XP_047303523.1, XP_047303532.1, XP_047303522.1, XP_047303519.1, NP_001171111.2, XP_047303515.1, XP_047303510.1, XP_047303526.1, NP_001171105.2, XP_047303512.1, NP_001171109.2, XP_047303505.1, XP_047303503.1, XP_047303524.1, NP_001171107.2, XP_047303498.1, XP_047303535.1, XP_047303521.1, XP_047303518.1, XP_047303525.1, XP_047303502.1, XP_047303504.1, XP_047303527.1, NP_001171110.2, XP_047303497.1, NP_001171113.2, XP_047303500.1, XP_047303499.1, XP_047303511.1, XP_047303530.1, XP_047303520.1, NP_001171115.2, XP_047303501.1, XP_047303517.1, XP_047303513.1, XP_047303531.1, XP_047303507.1, XP_047303509.1, XP_047303533.1, NP_004384.5, XP_047303496.1, XP_047303528.1

OpenTargets

ENSG00000173402

ENSEMBL

ENST00000418588, ENST00000452317, ENSP00000401805, ENST00000469139, ENST00000308775, ENST00000673708, ENSP00000410145, ENST00000496474, ENSP00000312435, ENST00000435508, ENST00000431960, ENST00000430636, ENSP00000401382, ENST00000466701, ENSP00000412067, ENST00000428779, ENST00000697271, ENSP00000415321, ENSP00000388833, ENSP00000405859, ENSG00000173402, ENSP00000501140, ENSP00000513216, ENSP00000501165, ENSP00000513217, ENSP00000513218, ENST00000452060, ENSP00000387859, ENST00000421560

GeneCards

DAG1

HPA

ENSG00000173402-DAG1

PRO

Q14118

Pharos - Targets

Q14118

GlyGen

Q14118

Orphanet

DAG1

PDB

2MK7, 6JJY, 7E9L, 7E9K, 5GGP, 1EG4, 5LLK

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14118 DAG1	20	DAG1(654-895) [plasma membrane] (R-HSA-2328154) DAG1(30-653) [extracellular region] (R-HSA-2328152) DAG1(30-653) [cytosol] (R-HSA-5615641) DAG1(30-653) [endoplasmic reticulum lumen] (R-HSA-8931890) Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-5615647) DAG1 [endoplasmic reticulum membrane] (R-HSA-9913254) DAG1(654-895) [endoplasmic reticulum membrane] (R-HSA-9913257) Core M1,3-DAG1 [Golgi lumen] (R-HSA-5617087) Core M1,2,3-DAG1 [Golgi lumen] (R-HSA-8932424) Core M3-DAG1 [Golgi lumen] (R-HSA-9940750) GalNAc-GlcNAc-Man6P-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931659) GalNAc-GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931656) GlcNAc-Man-DAG1 [endoplasmic reticulum lumen] (R-HSA-8931673) RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] (R-HSA-9940668) Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] (R-HSA-9940723) RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] (R-HSA-9940763) GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] (R-HSA-9940727) Xyl-GlcA-Xyl-RboP-RboP-GalNAc-GlcNAc-Man6P-DAG1 [Golgi lumen] (R-HSA-9940697) Matriglycan-DAG1 [Golgi lumen] (R-HSA-9940706) 3S-Matriglycan-DAG1 [Golgi lumen] (R-HSA-9940731)	0.558	2
UniProt:P46939 UTRN	1	UTRN [cytosol] (R-HSA-5216039)	0.527	2
UniProt:P33151 CDH5	2	p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435) VE-cadherin [plasma membrane] (R-HSA-418992)	0.527	2
UniProt:O00214 LEG8			0.527	2
UniProt:Q9NU53 GINM1			0.527	2
UniProt:Q9Y5G4 PCDG9			0.527	2
UniProt:Q8WXA8 HTR3C	1	HTR3C [plasma membrane] (R-HSA-975312)	0.527	2
UniProt:O95302 FKBP9	1	FKBP9 [cytosol] (R-HSA-391306)	0.527	2
UniProt:Q9Y5F2 PCDBB			0.527	2
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.527	2
UniProt:Q96GX1 TCTN2	1	TCTN2 [ciliary membrane] (R-HSA-5626661)	0.527	2
UniProt:P20036 HLA-DPA1	9	HLA class II histocompatibility antigen, DP alpha chain precursor [plasma membrane] (R-HSA-197586) HLA class II histocompatibility antigen, DP alpha chain precursor [lysosomal membrane] (R-HSA-2130639) HLA class II histocompatibility antigen, DP alpha chain precursor [endocytic vesicle membrane] (R-HSA-2130435) HLA class II histocompatibility antigen, DP alpha chain precursor [clathrin-coated endocytic vesicle membrane] (R-HSA-2130485) HLA class II histocompatibility antigen, DP alpha chain precursor [transport vesicle membrane] (R-HSA-2130648) HLA class II histocompatibility antigen, DP alpha chain precursor [trans-Golgi network membrane] (R-HSA-2130337) HLA class II histocompatibility antigen, DP alpha chain precursor [Golgi membrane] (R-HSA-2214387) HLA class II histocompatibility antigen, DP alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-2130739) HLA class II histocompatibility antigen, DP alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-2130667)	0.527	2
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:P32971 TNFSF8	1	TNFSF8 [plasma membrane] (R-HSA-5667148)	0.527	3
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	2
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.462	2

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