Reactome | CRTC2 [nucleoplasm]

CRTC2 [nucleoplasm]

Stable Identifier

R-HSA-8931951

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CREB-regulated transcription coactivator 2, CRTC2_HUMAN

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
    - Expression of PPARGC1A (PGC-1alpha) (Homo sapiens)
      - p-S133-CREB1:CRTC1,2,3:PPARGC1A gene [nucleoplasm] (Homo sapiens)
        
        CRTC1,2,3 [nucleoplasm] (Homo sapiens)
        
        CRTC2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q53ET0 CRTC2

Gene Names

CRTC2, TORC2

Chain

initiator methionine:, chain:2-693

Reference Genes

BioGPS Gene:200186 CRTC2

COSMIC (genes):CRTC2 CRTC2

CTD Gene:200186 CRTC2

dbSNP Gene:200186 CRTC2

ENSEMBL:ENSG00000160741 CRTC2

HGNC:27301 CRTC2

KEGG:hsa:200186 CRTC2

Monarch:200186 CRTC2

NCBI Gene:200186 CRTC2

OMIM:608972 CRTC2

UCSC:Q53ET0 CRTC2

Reference Transcript

RefSeq:NM_181715.2 CRTC2

Other Identifiers

11754562_a_at

16693601

200186

226307_PM_at

226307_at

2436337

2436339

2436340

2436341

2436342

2436343

2436344

2436345

2436346

2436347

2436348

2436349

2436350

2436351

2436352

2436353

2436354

2436355

2436356

2436357

2436358

2436359

2436360

2436361

2436362

2436363

2436364

2436365

2436366

2436367

2436370

2436371

2436372

2436374

2436375

2436376

2436377

55619_at

7920382

A_23_P12173

A_23_P12178

GE88069

GE88070

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005975

GO:0006094

GO:0006355

GO:0008140

GO:0032793

GO:0042593

GO:0043226

GO:0045944

GO:0051289

GO:0065003

GO:0070062

HMNXSV003054651

Hs.71243.1.A1_3p_at

ILMN_1657771

PH_hs_0019271

TC01003280.hg

Participates

as a member of

CRTC1,2,3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_859066.1

ENSEMBL

ENSP00000357622, ENST00000368633

OpenTargets

ENSG00000160741

HPA

ENSG00000160741-CRTC2

PRO

Q53ET0

Pharos - Targets

Q53ET0

GlyGen

Q53ET0

HMDB Protein

HMDBP07633

PDB

4HTM

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.848	7
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.725	6
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.643	4
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.556	5

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