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Me3K315-VCP [cytosol]
Stable Identifier
R-HSA-8932209
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p97 ATPase, Transitional endoplasmic reticulum ATPase, TERA_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O75175 CNOT3
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein methylation (Homo sapiens)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)
Me3K315-VCP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55072 VCP
Gene Names
VCP, HEL-220, HEL-S-70
Chain
initiator methionine:, chain:2-806
Reference Genes
BioGPS Gene:7415 VCP
COSMIC (genes):VCP VCP
CTD Gene:7415 VCP
dbSNP Gene:7415 VCP
ENSEMBL:ENSG00000165280 VCP
HGNC:12666 VCP
KEGG:hsa:7415 VCP
Monarch:7415 VCP
NCBI Gene:7415 VCP
OMIM:601023 VCP
UCSC:P55072 VCP
Reference Transcript
RefSeq:NM_007126.3 VCP
Other Identifiers
11733010_a_at
11745875_x_at
11746412_x_at
11758451_s_at
17093570
208648_PM_at
208648_at
208649_PM_s_at
208649_s_at
3204407
3204408
3204409
3204410
3204411
3204412
3204413
3204414
3204415
3204416
3204417
3204418
3204419
3204420
3204421
3204422
3204423
3204424
3204425
3204426
3204429
3204430
3204431
3204432
3204433
3204434
3204435
3204436
3204437
3204438
3204439
3204440
3204441
3204452
3204454
33818_at
44058_at
56348_at
7415
8160914
A_23_P83045
A_24_P127828
A_24_P295412
GE54792
GE79640
GO:0000502
GO:0003723
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005811
GO:0005829
GO:0006281
GO:0006302
GO:0006511
GO:0006734
GO:0006886
GO:0006888
GO:0006914
GO:0006919
GO:0006974
GO:0007010
GO:0008289
GO:0010494
GO:0010498
GO:0010918
GO:0016192
GO:0016236
GO:0016567
GO:0016787
GO:0016887
GO:0019079
GO:0019903
GO:0019904
GO:0019985
GO:0030163
GO:0030968
GO:0030970
GO:0031334
GO:0031593
GO:0031625
GO:0032436
GO:0032510
GO:0032991
GO:0034098
GO:0034605
GO:0034774
GO:0035331
GO:0035578
GO:0035617
GO:0035800
GO:0035861
GO:0036297
GO:0036435
GO:0036503
GO:0036513
GO:0042288
GO:0042802
GO:0042981
GO:0043161
GO:0043226
GO:0043231
GO:0043531
GO:0044389
GO:0044877
GO:0045184
GO:0045202
GO:0045732
GO:0045879
GO:0046034
GO:0048471
GO:0050807
GO:0051228
GO:0055086
GO:0060090
GO:0061857
GO:0070062
GO:0070842
GO:0071218
GO:0072389
GO:0090263
GO:0097352
GO:0098772
GO:0098978
GO:0106300
GO:0120186
GO:0140036
GO:0140455
GO:1901135
GO:1901224
GO:1903006
GO:1903007
GO:1903715
GO:1903843
GO:1903862
GO:1904288
GO:1904813
GO:1904949
GO:1905634
GO:1990381
GO:1990730
GO:2000060
GO:2001171
HMNXSV003053327
Hs.106357.0.S2_3p_at
ILMN_1777220
PH_hs_0024763
TC09001048.hg
TC09002468.hg
g5410289_3p_a_at
Participates
as an output of
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)
Other forms of this molecule
VCP [cytosol]
VCP [secretory granule lumen]
VCP [extracellular region]
VCP [azurophil granule lumen]
VCP [ficolin-1-rich granule lumen]
VCP [nucleoplasm]
VCP [endoplasmic reticulum membrane]
Inferred To
cdcD [cytosol]
(Dictyostelium discoideum)
Me3K315-VCP [cytosol]
(Caenorhabditis elegans)
Me3K315-VCP [cytosol]
(Danio rerio)
Me3K315-VCP [cytosol]
(Drosophila melanogaster)
Me3K315-VCP [cytosol]
(Mus musculus)
Me3K315-VCP [cytosol]
(Plasmodium falciparum)
Me3K315-VCP [cytosol]
(Rattus norvegicus)
Me3K315-VCP [cytosol]
(Saccharomyces cerevisiae)
Me3K315-VCP [cytosol]
(Schizosaccharomyces pombe)
Me3K315-VCP [cytosol]
(Sus scrofa)
Me3K315-VCP [cytosol]
(Xenopus tropicalis)
VCP [cytosol]
(Bos taurus)
VCP [cytosol]
(Canis familiaris)
VCP [cytosol]
(Gallus gallus)
Modified Residues
Name
N6,N6,N6-trimethyl-L-lysine at 315
Coordinate
315
PsiMod Name
N6,N6,N6-trimethyl-L-lysine [MOD:00083]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.
Cross References
RefSeq
NP_009057.1
OpenTargets
ENSG00000165280
ENSEMBL
ENSP00000351777
,
ENST00000358901
ZINC - Substances
TERA_HUMAN
ZINC target
P55072
PRO
P55072
GlyGen
P55072
PDB
3HU1
,
7RLA
,
7RLJ
,
7LN4
,
7RL7
,
7Y59
,
5IFS
,
5GLF
,
4KDI
,
5C18
,
7VCU
,
4KDL
,
7RLF
,
7MDO
,
7R7S
,
7R7U
,
5FTN
,
8FCP
,
5X4L
,
3QWZ
,
5KIY
,
6G2W
,
7MDM
,
3TIW
,
7BPB
,
8HL7
,
8FCR
,
5EPP
,
7VCT
,
7RL9
,
7LN1
,
7RL6
,
7Y4W
,
7OAT
,
6HD0
,
7MHS
,
5C1A
,
5C1B
,
7LN0
,
7RLG
,
7VCS
,
7K59
,
8PQX
,
3QQ7
,
8FCM
,
5FTM
,
8RS9
,
5FTL
,
6G2Z
,
7LMZ
,
7BP8
,
8FCT
,
6G2V
,
7L5X
,
8HRZ
,
7RLD
,
7RLC
,
7LN3
,
3HU3
,
8VLS
,
7LN5
,
4KOD
,
3EBB
,
5IFW
,
5C19
,
8R0E
,
7R7T
,
7LN6
,
7RLH
,
7JY5
,
7K57
,
3QQ8
,
8RSB
,
8FCN
,
8FCO
,
8RSC
,
7LMY
,
8FCL
,
5FTJ
,
7BP9
,
5DYI
,
8KG2
,
6MCK
,
7RLI
,
7Y53
,
3HU2
,
4KLN
,
4KO8
,
8B5R
,
7VCV
,
3QC8
,
7PUX
,
7LN2
,
4P0A
,
7RLB
,
8VOV
,
7VCX
,
8OOI
,
7K56
,
5B6C
,
5KIW
,
8VKU
,
5FTK
,
6G2Y
,
6G30
,
5DYG
,
6G2X
,
8FCQ
,
7L5W
,
7BPA
IntEnz
3.6.4.6
HPA
ENSG00000165280-VCP
Pharos - Targets
P55072
Orphanet
VCP
ZINC - Predictions - Purchasable
TERA_HUMAN
HMDB Protein
HMDBP11971
Interactors (77)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UNZ2 NSFL1C
1
NSFL1C [cytosol]
(R-HSA-9714673)
0.965
26
UniProt:Q9BZE9 ASPSCR1
1
ASPSCR1 [cytoplasmic vesicle membrane]
(R-HSA-1449582)
0.963
34
UniProt:Q8TAT6 NPLOC4
2
NPLOC4 [nucleoplasm]
(R-HSA-5654987)
NPLOC4 [cytosol]
(R-HSA-9755492)
0.95
15
UniProt:P68543 UBX2A
0.94
20
UniProt:Q9BZV1 UBXN6
0.933
23
UniProt:Q14CS0 UBX2B
0.913
16
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.884
8
UniProt:Q9UKV5 AMFR
1
AMFR [endoplasmic reticulum membrane]
(R-HSA-975999)
0.874
12
UniProt:Q969W3 VCF1
0.85
10
UniProt:Q92890 UFD1L
2
UFD1L [nucleoplasm]
(R-HSA-5654993)
UFD1 [cytosol]
(R-HSA-9668519)
0.845
8
UniProt:P54252-1 ATXN3
0.833
18
UniProt:Q96CS3 FAF2
3
FAF2 [cytosol]
(R-HSA-6781921)
FAF2 [extracellular region]
(R-HSA-6806183)
FAF2 [azurophil granule lumen]
(R-HSA-6799138)
0.826
14
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.821
19
UniProt:Q9Y263 PLAP
0.782
7
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.781
7
UniProt:Q92575 UBXN4
0.741
12
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.718
6
UniProt:Q96HA8 NTAQ1
0.718
6
UniProt:Q96LK0 CEP19
0.718
6
UniProt:O94941 UBOX5
1
UBOX5 [cytosol]
(R-HSA-976034)
0.718
6
UniProt:P32969 RPL9
1
RPL9 [cytosol]
(R-HSA-72492)
0.718
6
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.706
21
UniProt:O00124 UBXN8
0.695
9
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.675
4
UniProt:O60941 DTNB
1
DTNB [plasma membrane]
(R-HSA-9630734)
0.666
4
UniProt:Q9H0K1 SIK2
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:Q04323 UBXN1
2
UBXN1 [cytosol]
(R-HSA-8850588)
UBXN1 [nucleoplasm]
(R-HSA-9707052)
0.666
7
UniProt:Q13617 CUL2
3
CUL2 [cytosol]
(R-HSA-416982)
CUL2 [nucleoplasm]
(R-HSA-1234126)
G76-NEDD8-K689-CUL2 [cytosol]
(R-HSA-8952511)
0.643
3
UniProt:Q96IV0 NGLY1
1
NGLY1 [cytosol]
(R-HSA-8850591)
0.643
3
UniProt:Q9UNN5 FAF1
0.641
3
UniProt:Q9UNN5-1 FAF1
0.618
4
UniProt:Q96LJ8 UBX10
0.604
7
UniProt:Q96EQ8 RNF125
2
RNF125 [cytosol]
(R-HSA-918184)
K48polyUb-RNF125 [cytosol]
(R-HSA-3080560)
0.591
3
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.589
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.573
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.57
3
UniProt:P09471 GNAO1
1
GNAO1 [plasma membrane]
(R-HSA-2997536)
0.556
3
UniProt:O75175 CNOT3
1
CNOT3 [cytosol]
(R-HSA-429872)
0.556
3
UniProt:Q8NBI5 S43A3
0.556
3
UniProt:O76064 RNF8
1
RNF8 [nucleoplasm]
(R-HSA-5682539)
0.556
3
UniProt:P46977 STT3A
1
STT3A [endoplasmic reticulum membrane]
(R-HSA-265023)
0.556
3
UniProt:A9UGY9 A9UGY9
0.556
3
UniProt:P26378-2 P263782
0.556
3
UniProt:Q16560-2 SNRNP35
0.556
3
UniProt:Q96J88-3 Q96J883
0.556
3
UniProt:P54253 ATX1
0.556
3
UniProt:O60941-5 DTNB
0.556
3
UniProt:P24278 ZBT25
0.556
3
UniProt:Q9H7H0-2 METTL17
0.556
3
UniProt:Q8WZA0 LZIC
0.556
3
UniProt:Q9Y4L5 RNF115
1
RNF115 [cytosol]
(R-HSA-8850904)
0.556
3
UniProt:Q07869 PPARA
2
PPARA [nucleoplasm]
(R-HSA-400186)
monoSUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
0.556
3
UniProt:Q6GPH4 XAF1
1
XAF1 [cytosol]
(R-HSA-1015680)
0.556
3
UniProt:P62191 PSMC1
2
PSMC1 [cytosol]
(R-HSA-68768)
PSMC1 [nucleoplasm]
(R-HSA-174338)
0.556
3
UniProt:Q5VVQ6 YOD1
1
YOD1 [cytosol]
(R-HSA-6781909)
0.556
3
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.556
3
UniProt:P63027 VAMP2
20
VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-379363)
VAMP2 [plasma membrane]
(R-HSA-210516)
VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917738)
VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-210365)
VAMP2 [synaptic vesicle membrane]
(R-HSA-181517)
VAMP2(59-116) [synaptic vesicle membrane]
(R-HSA-5250891)
VAMP2(2-58) [cytosol]
(R-HSA-194815)
VAMP2(2-76) [cytosol]
(R-HSA-194802)
VAMP2(77-116) [synaptic vesicle membrane]
(R-HSA-5228355)
VAMP2(60-116) [synaptic vesicle membrane]
(R-HSA-5250615)
VAMP2(2-59) [cytosol]
(R-HSA-194797)
VAMP2(82-116) [synaptic vesicle membrane]
(R-HSA-5250961)
VAMP2(2-81) [cytosol]
(R-HSA-5250970)
VAMP2 [secretory granule membrane]
(R-HSA-376363)
VAMP2 [cytosol]
(R-HSA-9609882)
VAMP2 [endoplasmic reticulum membrane]
(R-HSA-9609886)
VAMP2 [cytoplasmic vesicle membrane]
(R-HSA-1449630)
VAMP2 [lysosomal membrane]
(R-HSA-432703)
VAMP2 [Golgi membrane]
(R-HSA-375425)
VAMP2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869129)
0.556
3
UniProt:Q9BUN8 DERL1
1
DERL1 [endoplasmic reticulum membrane]
(R-HSA-6781898)
0.527
2
UniProt:Q96S82 UBL7
0.527
2
UniProt:Q9BQE4 SELENOS
1
VIMP [endoplasmic reticulum membrane]
(R-HSA-8943099)
0.527
2
UniProt:O60260 PARK2
4
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
PRKN [cytosol]
(R-HSA-201579)
0.527
2
UniProt:P04114 APOB
20
APOB(28-2179) [cytosol]
(R-HSA-2395786)
APOB(28-2179) [early endosome]
(R-HSA-2429651)
APOB(28-4563) [lysosomal lumen]
(R-HSA-8876369)
APOB(28-2179) [endosome lumen]
(R-HSA-174716)
APOB(28-2179) [endosome membrane]
(R-HSA-174762)
APOB(28-4563) [plasma membrane]
(R-HSA-171089)
APOB(28-4563) [clathrin-coated endocytic vesicle membrane]
(R-HSA-171155)
APOB(28-4563) [endosome lumen]
(R-HSA-171119)
APOB(28-4563) [endosome membrane]
(R-HSA-171121)
APOB(28-2179) [clathrin-coated endocytic vesicle membrane]
(R-HSA-174788)
APOB(28-2179) [plasma membrane]
(R-HSA-174625)
APOB(28-4563) [extracellular region]
(R-HSA-171065)
10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [extracellular region]
(R-HSA-2173702)
APOB(28-4563) [endoplasmic reticulum membrane]
(R-HSA-6784882)
p-APOB(28-4563) [endoplasmic reticulum lumen]
(R-HSA-8957068)
AcK-APOB(28-4563) [extracellular region]
(R-HSA-2173751)
AcK-APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2239446)
10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2239461)
APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2512789)
APOB(28-4563) [smooth endoplasmic reticulum]
(R-HSA-8866317)
0.527
2
UniProt:Q9H867 VCPKMT
1
VCPKMT [cytosol]
(R-HSA-8876681)
0.527
4
UniProt:Q96JH7 VCPIP1
2
p-S131-VCPIP1 [endoplasmic reticulum lumen]
(R-HSA-8940104)
VCPIP1 [endoplasmic reticulum lumen]
(R-HSA-8940103)
0.527
2
UniProt:B1AQ61 B1AQ61
0.525
4
UniProt:Q9HC29 NOD2
1
NOD2 [cytosol]
(R-HSA-168411)
0.524
4
UniProt:O96017 CHEK2
3
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
0.524
2
UniProt:P26045 PTPN3
3
PTPN3 [cytosol]
(R-HSA-8867650)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [plasma membrane]
(R-HSA-5490317)
0.524
2
UniProt:O94868 FCSD2
0.508
2
UniProt:Q13619 CUL4A
2
CUL4A [nucleoplasm]
(R-HSA-976006)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(R-HSA-8952514)
0.499
2
UniProt:Q9WTX6
3
Cul1 [cytosol]
(R-MMU-8952519)
Cul1 [nucleoplasm]
(R-MMU-187551)
Cul1 [cytosol]
(R-MMU-174230)
0.499
2
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.499
2
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.488
2
UniProt:Q5T124-6 UBXN11
0.471
7
UniProt:P04578-PRO_0000038428 ENV
0.462
2
UniProt:Q86TM6 SYVN1
1
SYVN1(1-617) [endoplasmic reticulum membrane]
(R-HSA-535496)
0.462
2
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