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Me3K315-VCP [cytosol]
Stable Identifier
R-HSA-8932209
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p97 ATPase, Transitional endoplasmic reticulum ATPase, TERA_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P54252 ATXN3
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein methylation (Homo sapiens)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)
Me3K315-VCP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55072 VCP
Gene Names
VCP, HEL-220, HEL-S-70
Chain
initiator methionine:, chain:2-806
Reference Genes
BioGPS Gene:7415 VCP
COSMIC (genes):VCP VCP
CTD Gene:7415 VCP
dbSNP Gene:7415 VCP
ENSEMBL:ENSG00000165280 VCP
ENSEMBL_homo_sapiens_GENE:ENSG00000165280.18 VCP
HGNC:12666 VCP
KEGG Gene (Homo sapiens):7415 VCP
Monarch:7415 VCP
NCBI Gene:7415 VCP
OMIM:601023 VCP
Reference Transcript
RefSeq:NM_007126.3 VCP
Other Identifiers
11733010_a_at
11745875_x_at
11746412_x_at
11758451_s_at
17093570
208648_PM_at
208648_at
208649_PM_s_at
208649_s_at
3204407
3204408
3204409
3204410
3204412
3204414
3204415
3204417
3204419
3204420
3204421
3204422
3204423
3204425
3204426
3204429
3204430
3204432
3204433
3204435
3204437
3204440
3204441
3204454
33818_at
44058_at
56348_at
7415
8160914
A_23_P83045
A_24_P295412
GE54792
GE79640
GO:0000166
GO:0000278
GO:0000502
GO:0003723
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005764
GO:0005773
GO:0005783
GO:0005789
GO:0005811
GO:0005829
GO:0006091
GO:0006281
GO:0006302
GO:0006511
GO:0006734
GO:0006886
GO:0006888
GO:0006914
GO:0006919
GO:0006974
GO:0007010
GO:0008289
GO:0010494
GO:0010498
GO:0010918
GO:0012501
GO:0016192
GO:0016236
GO:0016567
GO:0016787
GO:0016887
GO:0019079
GO:0019903
GO:0019904
GO:0019985
GO:0023052
GO:0030163
GO:0030433
GO:0030968
GO:0030970
GO:0031334
GO:0031410
GO:0031593
GO:0031625
GO:0032436
GO:0032510
GO:0032991
GO:0033554
GO:0034098
GO:0034330
GO:0034605
GO:0034774
GO:0035578
GO:0035617
GO:0035800
GO:0035861
GO:0036211
GO:0036297
GO:0036435
GO:0036503
GO:0036513
GO:0042288
GO:0042802
GO:0042981
GO:0043161
GO:0043226
GO:0043231
GO:0043531
GO:0044389
GO:0044877
GO:0045184
GO:0045202
GO:0045732
GO:0045879
GO:0046034
GO:0048471
GO:0050807
GO:0051228
GO:0055086
GO:0061857
GO:0065003
GO:0070062
GO:0070842
GO:0071218
GO:0071712
GO:0072389
GO:0090263
GO:0097352
GO:0098772
GO:0098978
GO:0106300
GO:0120186
GO:0140036
GO:0140657
GO:1901135
GO:1901224
GO:1903006
GO:1903007
GO:1903715
GO:1903843
GO:1903862
GO:1904288
GO:1904813
GO:1904949
GO:1905634
GO:1990381
GO:1990730
GO:2000060
GO:2001171
HMNXSV003053327
Hs.106357.0.S2_3p_at
ILMN_1777220
PH_hs_0024763
TC09001048.hg
TC09002468.hg
g5410289_3p_a_at
Participates
as an output of
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Homo sapiens)
Other forms of this molecule
VCP [endoplasmic reticulum membrane]
VCP [nucleoplasm]
VCP [secretory granule lumen]
VCP [ficolin-1-rich granule lumen]
VCP [extracellular region]
VCP [azurophil granule lumen]
VCP [cytosol]
Inferred To
cdcD [cytosol]
(Dictyostelium discoideum)
Me3K315-VCP [cytosol]
(Caenorhabditis elegans)
Me3K315-VCP [cytosol]
(Danio rerio)
Me3K315-VCP [cytosol]
(Drosophila melanogaster)
Me3K315-VCP [cytosol]
(Mus musculus)
Me3K315-VCP [cytosol]
(Plasmodium falciparum)
Me3K315-VCP [cytosol]
(Rattus norvegicus)
Me3K315-VCP [cytosol]
(Saccharomyces cerevisiae)
Me3K315-VCP [cytosol]
(Schizosaccharomyces pombe)
Me3K315-VCP [cytosol]
(Sus scrofa)
Me3K315-VCP [cytosol]
(Xenopus tropicalis)
VCP [cytosol]
(Bos taurus)
VCP [cytosol]
(Canis familiaris)
VCP [cytosol]
(Gallus gallus)
Modified Residues
Name
N6,N6,N6-trimethyl-L-lysine at 315
Coordinate
315
PsiMod Name
N6,N6,N6-trimethyl-L-lysine [MOD:00083]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.
Cross References
RefSeq
NP_009057.1
OpenTargets
ENSG00000165280
ZINC - Substances
TERA_HUMAN
ZINC target
P55072
PRO
P55072
PDB
7RL9
,
5IFW
,
7LN6
,
7RLA
,
7VCT
,
7LN2
,
5X4L
,
5FTM
,
4P0A
,
4KDL
,
8HL7
,
8FCT
,
5EPP
,
7RLD
,
4KOD
,
7MHS
,
8HRZ
,
3HU3
,
7RLF
,
5B6C
,
7LMZ
,
7Y53
,
6G2Z
,
7LN5
,
8FCR
,
7RL6
,
5DYG
,
7R7T
,
7MDO
,
5C18
,
7RLJ
,
8FCL
,
7RLI
,
6G2X
,
5C1B
,
7LN3
,
8B5R
,
8FCN
,
7L5W
,
5FTN
,
6G2Y
,
5C1A
,
7R7S
,
5FTK
,
6G30
,
8FCO
,
7BPB
,
6G2V
,
5IFS
,
3HU2
,
7LN1
,
5FTL
,
7RLG
,
4KLN
,
7K56
,
7RLB
,
3HU1
,
7BP9
,
6HD0
,
6MCK
,
3EBB
,
7VCV
,
7RLC
,
7LMY
,
7K59
,
7Y59
,
3QQ8
,
4KDI
,
5KIW
,
7MDM
,
5C19
,
7R7U
,
7RLH
,
3QQ7
,
8FCQ
,
7BP8
,
3QC8
,
6G2W
,
5KIY
,
7RL7
,
3QWZ
,
7OAT
,
7PUX
,
8OOI
,
7JY5
,
7VCS
,
7K57
,
5DYI
,
7Y4W
,
5GLF
,
5FTJ
,
7VCU
,
7BPA
,
8FCM
,
7LN4
,
8FCP
,
7VCX
,
7L5X
,
3TIW
,
7LN0
,
4KO8
IntEnz
3.6.4.6
HPA
ENSG00000165280-VCP
GeneCards
P55072
Ensembl
ENSG00000165280
,
ENST00000358901
,
ENSP00000351777
Pharos - Targets
P55072
Orphanet
15706
ZINC - Predictions - Purchasable
TERA_HUMAN
HMDB Protein
HMDBP11971
Interactors (77)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UNZ2 NSFL1C
1
NSFL1C [cytosol]
(R-HSA-9714673)
0.965
26
UniProt:Q9BZE9 ASPSCR1
1
ASPSCR1 [cytoplasmic vesicle membrane]
(R-HSA-1449582)
0.963
34
UniProt:Q8TAT6 NPLOC4
2
NPLOC4 [nucleoplasm]
(R-HSA-5654987)
NPLOC4 [cytosol]
(R-HSA-9755492)
0.95
15
UniProt:P68543 UBX2A
0.94
20
UniProt:Q9BZV1 UBXN6
0.933
23
UniProt:Q14CS0 UBX2B
0.913
16
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.884
8
UniProt:Q9UKV5 AMFR
1
AMFR [endoplasmic reticulum membrane]
(R-HSA-975999)
0.874
12
UniProt:Q969W3 VCF1
0.85
10
UniProt:Q92890 UFD1L
2
UFD1L [nucleoplasm]
(R-HSA-5654993)
UFD1 [cytosol]
(R-HSA-9668519)
0.845
8
UniProt:P54252-1 ATXN3
0.833
18
UniProt:Q96CS3 FAF2
3
FAF2 [cytosol]
(R-HSA-6781921)
FAF2 [extracellular region]
(R-HSA-6806183)
FAF2 [azurophil granule lumen]
(R-HSA-6799138)
0.826
14
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.821
19
UniProt:Q9Y263 PLAP
0.782
7
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.781
7
UniProt:Q92575 UBXN4
0.741
12
UniProt:P25786 PSMA1
2
PSMA1 [nucleoplasm]
(R-HSA-174333)
PSMA1 [cytosol]
(R-HSA-68724)
0.718
6
UniProt:Q96HA8 NTAQ1
0.718
6
UniProt:Q96LK0 CEP19
0.718
6
UniProt:O94941 UBOX5
1
UBOX5 [cytosol]
(R-HSA-976034)
0.718
6
UniProt:P32969 RPL9
1
RPL9 [cytosol]
(R-HSA-72492)
0.718
6
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
21
UniProt:O00124 UBXN8
0.695
9
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.675
4
UniProt:O60941 DTNB
0.666
4
UniProt:Q04323 UBXN1
2
UBXN1 [cytosol]
(R-HSA-8850588)
UBXN1 [nucleoplasm]
(R-HSA-9707052)
0.666
7
UniProt:Q9H0K1 SIK2
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:Q13617 CUL2
3
G76-NEDD8-K689-CUL2 [cytosol]
(R-HSA-8952511)
CUL2 [nucleoplasm]
(R-HSA-1234126)
CUL2 [cytosol]
(R-HSA-416982)
0.643
3
UniProt:Q96IV0 NGLY1
1
NGLY1 [cytosol]
(R-HSA-8850591)
0.643
3
UniProt:Q9UNN5 FAF1
0.641
3
UniProt:Q9UNN5-1 FAF1
0.618
4
UniProt:Q96LJ8 UBX10
0.604
7
UniProt:Q96EQ8 RNF125
2
RNF125 [cytosol]
(R-HSA-918184)
K48polyUb-RNF125 [cytosol]
(R-HSA-3080560)
0.591
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.589
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.573
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.57
3
UniProt:P09471 GNAO1
1
GNAO1 [plasma membrane]
(R-HSA-2997536)
0.556
3
UniProt:O75175 CNOT3
1
CNOT3 [cytosol]
(R-HSA-429872)
0.556
3
UniProt:Q8NBI5 S43A3
0.556
3
UniProt:O76064 RNF8
1
RNF8 [nucleoplasm]
(R-HSA-5682539)
0.556
3
UniProt:P46977 STT3A
1
STT3A [endoplasmic reticulum membrane]
(R-HSA-265023)
0.556
3
UniProt:A9UGY9 A9UGY9
0.556
3
UniProt:P63027 VAMP2
20
VAMP2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869129)
VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-379363)
VAMP2 [plasma membrane]
(R-HSA-210516)
VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917738)
VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-210365)
VAMP2 [synaptic vesicle membrane]
(R-HSA-181517)
VAMP2(59-116) [synaptic vesicle membrane]
(R-HSA-5250891)
VAMP2(2-58) [cytosol]
(R-HSA-194815)
VAMP2(2-76) [cytosol]
(R-HSA-194802)
VAMP2(77-116) [synaptic vesicle membrane]
(R-HSA-5228355)
VAMP2(60-116) [synaptic vesicle membrane]
(R-HSA-5250615)
VAMP2(2-59) [cytosol]
(R-HSA-194797)
VAMP2(82-116) [synaptic vesicle membrane]
(R-HSA-5250961)
VAMP2(2-81) [cytosol]
(R-HSA-5250970)
VAMP2 [secretory granule membrane]
(R-HSA-376363)
VAMP2 [cytosol]
(R-HSA-9609882)
VAMP2 [endoplasmic reticulum membrane]
(R-HSA-9609886)
VAMP2 [cytoplasmic vesicle membrane]
(R-HSA-1449630)
VAMP2 [lysosomal membrane]
(R-HSA-432703)
VAMP2 [Golgi membrane]
(R-HSA-375425)
0.556
3
UniProt:Q07869 PPARA
2
monoSUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
PPARA [nucleoplasm]
(R-HSA-400186)
0.556
3
UniProt:P26378-2 P263782
0.556
3
UniProt:Q16560-2 SNRNP35
0.556
3
UniProt:Q96J88-3 Q96J883
0.556
3
UniProt:P54253 ATX1
0.556
3
UniProt:O60941-5 DTNB
0.556
3
UniProt:Q5VVQ6 YOD1
1
YOD1 [cytosol]
(R-HSA-6781909)
0.556
3
UniProt:P24278 ZBT25
0.556
3
UniProt:Q9H7H0-2 METTL17
0.556
3
UniProt:Q8WZA0 LZIC
0.556
3
UniProt:Q9Y4L5 RNF115
1
RNF115 [cytosol]
(R-HSA-8850904)
0.556
3
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.556
3
UniProt:P62191 PSMC1
2
PSMC1 [nucleoplasm]
(R-HSA-174338)
PSMC1 [cytosol]
(R-HSA-68768)
0.556
3
UniProt:Q6GPH4 XAF1
1
XAF1 [cytosol]
(R-HSA-1015680)
0.556
3
UniProt:Q96JH7 VCPIP1
2
p-S131-VCPIP1 [endoplasmic reticulum lumen]
(R-HSA-8940104)
VCPIP1 [endoplasmic reticulum lumen]
(R-HSA-8940103)
0.527
2
UniProt:Q9BUN8 DERL1
1
DERL1 [endoplasmic reticulum membrane]
(R-HSA-6781898)
0.527
2
UniProt:P04114 APOB
20
APOB(28-2179) [cytosol]
(R-HSA-2395786)
APOB(28-2179) [early endosome]
(R-HSA-2429651)
APOB(28-4563) [lysosomal lumen]
(R-HSA-8876369)
APOB(28-2179) [endosome lumen]
(R-HSA-174716)
APOB(28-2179) [endosome membrane]
(R-HSA-174762)
APOB(28-4563) [plasma membrane]
(R-HSA-171089)
APOB(28-4563) [clathrin-coated endocytic vesicle membrane]
(R-HSA-171155)
APOB(28-4563) [endosome lumen]
(R-HSA-171119)
APOB(28-4563) [endosome membrane]
(R-HSA-171121)
APOB(28-2179) [clathrin-coated endocytic vesicle membrane]
(R-HSA-174788)
APOB(28-2179) [plasma membrane]
(R-HSA-174625)
APOB(28-2179) [endoplasmic reticulum lumen]
(R-HSA-174620)
APOB(28-2179) [extracellular region]
(R-HSA-174770)
APOB(28-2179) [endoplasmic reticulum membrane]
(R-HSA-174637)
APOB(28-4563) [smooth endoplasmic reticulum]
(R-HSA-8866317)
10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2239461)
APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2512789)
AcK-APOB(28-4563) [endocytic vesicle lumen]
(R-HSA-2239446)
AcK-APOB(28-4563) [extracellular region]
(R-HSA-2173751)
p-APOB(28-4563) [endoplasmic reticulum lumen]
(R-HSA-8957068)
0.527
2
UniProt:Q9H867 VCPKMT
1
VCPKMT [cytosol]
(R-HSA-8876681)
0.527
4
UniProt:Q96S82 UBL7
0.527
2
UniProt:Q9BQE4 SELENOS
1
VIMP [endoplasmic reticulum membrane]
(R-HSA-8943099)
0.527
2
UniProt:O60260 PARK2
4
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
PRKN [cytosol]
(R-HSA-201579)
0.527
2
UniProt:B1AQ61 B1AQ61
0.525
4
UniProt:Q9HC29 NOD2
1
NOD2 [cytosol]
(R-HSA-168411)
0.524
4
UniProt:P26045 PTPN3
3
PTPN3 [plasma membrane]
(R-HSA-5490317)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [cytosol]
(R-HSA-8867650)
0.524
2
UniProt:O96017 CHEK2
3
p-T68-CHEK2 [nucleoplasm]
(R-HSA-113825)
CHEK2 [nucleoplasm]
(R-HSA-113824)
p-S,3T-CHEK2 [nucleoplasm]
(R-HSA-5683784)
0.524
2
UniProt:O94868 FCSD2
0.508
2
UniProt:Q13619 CUL4A
2
CUL4A [nucleoplasm]
(R-HSA-976006)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(R-HSA-8952514)
0.499
2
UniProt:Q9WTX6
3
Cul1 [cytosol]
(R-MMU-8952519)
Cul1 [nucleoplasm]
(R-MMU-187551)
Cul1 [cytosol]
(R-MMU-174230)
0.499
2
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.499
2
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.488
2
UniProt:Q5T124-6 UBXN11
0.471
7
UniProt:P04578-PRO_0000038428 ENV
0.462
2
UniProt:Q86TM6 SYVN1
1
SYVN1(1-617) [endoplasmic reticulum membrane]
(R-HSA-535496)
0.462
2
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