DAG1 core M3 glycosylations

Stable Identifier
R-HSA-8932505
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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DAG1 core M3 glycosylations
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Core M3 glycans are initiated by beta-1,4-linked GlcNAc extension of O-mannose and always contain the trisaccharide linker glycan GalNAc-GlcNAc-ManP bound to O-threonines of the core protein. The only glycan known to be bound to Core M3 is matriglycan, a glycosaminoglycan (GAG)-like polysaccharide consisting of a long linear chain of repeating [-3GlcAβ1,3Xylα1-] heterodisaccharide and two ribitolphosphate subunits (reviewed in Praissman & Wells 2014; Katz & Diskin, 2024).
Literature References
PubMed ID Title Journal Year
38516183 The underlying mechanisms of arenaviral entry through matriglycan

Katz, M, Diskin, R

Front Mol Biosci 2024
24786756 Mammalian O-mannosylation pathway: glycan structures, enzymes, and protein substrates

Praissman, JL, Wells, L

Biochemistry 2014
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Events
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Event Information
Go Biological Process
protein O-linked glycosylation (0006493)
Orthologous Events
DAG1 core M3 glycosylations (Bos taurus)
DAG1 core M3 glycosylations (Canis familiaris)
DAG1 core M3 glycosylations (Danio rerio)
DAG1 core M3 glycosylations (Drosophila melanogaster)
DAG1 core M3 glycosylations (Gallus gallus)
DAG1 core M3 glycosylations (Mus musculus)
DAG1 core M3 glycosylations (Rattus norvegicus)
DAG1 core M3 glycosylations (Sus scrofa)
DAG1 core M3 glycosylations (Xenopus tropicalis)
Authored
Jassal, B  (2016-07-26)
Reviewed
Zaru, R  (2025-05-01)
Created
Jassal, B  (2016-07-26)
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