DAG1 core M1 glycosylations

Stable Identifier
R-HSA-8932506
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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DAG1 core M1 glycosylations
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Protein-linked O-mannose glycans are initiated by the covalent attachment of mannose to serine and threonine residues in the protein via alpha-linkages. Core M1 glycans consist of all O-mannose glycans in which O-mannose is extended with beta-1,2-linked N-acetylglucosamine (GlcNAc) but not with beta-1,6-linked GlcNAc. M1 structures do not directly bind key extracellular components but are essential as precursors for M2 structures, and they support the maturation of M3 glycans (Praissman & Wells 2014; Endo, 2019).
Literature References
PubMed ID Title Journal Year
24786756 Mammalian O-mannosylation pathway: glycan structures, enzymes, and protein substrates

Praissman, JL, Wells, L

Biochemistry 2014
30643095 Mammalian O-mannosyl glycans: Biochemistry and glycopathology

Endo, T

Proc Jpn Acad Ser B Phys Biol Sci 2019
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Events
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Event Information
Go Biological Process
protein O-linked glycosylation (0006493)
Orthologous Events
DAG1 core M1 glycosylations (Bos taurus)
DAG1 core M1 glycosylations (Canis familiaris)
DAG1 core M1 glycosylations (Danio rerio)
DAG1 core M1 glycosylations (Drosophila melanogaster)
DAG1 core M1 glycosylations (Gallus gallus)
DAG1 core M1 glycosylations (Mus musculus)
DAG1 core M1 glycosylations (Rattus norvegicus)
DAG1 core M1 glycosylations (Sus scrofa)
DAG1 core M1 glycosylations (Xenopus tropicalis)
Authored
Jassal, B  (2016-07-26)
Reviewed
Zaru, R  (2025-05-01)
Created
Jassal, B  (2016-07-26)
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