Reactome | PON2 [extracellular region]

PON2 [extracellular region]

Stable Identifier

R-HSA-8932636

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Serum paraoxonase/arylesterase 2, PON2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Fatty acid metabolism (Homo sapiens)
    - Arachidonate metabolism (Homo sapiens)
      - Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
        
        PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE (Homo sapiens)
        
        PON1,2,3:2xCa2+ dimers [extracellular region] (Homo sapiens)
        
        PON2:2xCa2+ dimer [extracellular region] (Homo sapiens)
        
        PON2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15165 PON2

Gene Names

PON2

Chain

chain:1-354, signal peptide:1-

Reference Genes

BioGPS Gene:5445 PON2

COSMIC (genes):PON2 PON2

CTD Gene:5445 PON2

dbSNP Gene:5445 PON2

ENSEMBL:ENSG00000105854 PON2

HGNC:9205 PON2

KEGG:hsa:5445 PON2

Monarch:5445 PON2

NCBI Gene:5445 PON2

OMIM:602447 PON2

UCSC:Q15165 PON2

Reference Transcript

Other Identifiers

11737479_a_at

11737480_x_at

11741354_a_at

17059932

201876_PM_at

201876_at

210830_PM_s_at

210830_s_at

242700_PM_at

242700_at

3061998

3061999

3062000

3062001

3062003

3062004

3062006

3062010

3062011

3062012

3062013

3062014

3062016

3062017

3062018

3062019

3062020

3062021

3062022

3062023

3062025

3062026

3062027

3062028

3062029

3062032

3062033

3062040

3062041

3062042

40504_at

5445

59415_at

8141076

A_23_P31399

GE54041

GO:0004064

GO:0005515

GO:0005576

GO:0005886

GO:0009636

GO:0016020

GO:0016787

GO:0042803

GO:0046872

GO:0102007

GO:1901335

HMNXSV003006756

Hs.165598.0.A1_3p_at

ILMN_1714158

ILMN_2354381

L48513_at

PH_hs_0022782

PH_hs_0031950

TC07001617.hg

TC07003069.hg

g2228776_3p_a_at

g4505952_3p_at

Participates

as a component of

PON2:2xCa2+ dimer [extracellular region] (Homo sapiens)

Inferred To

pon1 [extracellular region] (Danio rerio)

Pon2 [extracellular region] (Mus musculus)

Pon2 [extracellular region] (Rattus norvegicus)

PON1 [extracellular region] (Gallus gallus)

PON2 [extracellular region] (Bos taurus)

PON2 [extracellular region] (Canis familiaris)

PON2 [extracellular region] (Sus scrofa)

Homologues of PON2 [extracellular region] (Caenorhabditis elegans)

Homologues of PON2 [extracellular region] (Danio rerio)

poml-3 [extracellular region] (Caenorhabditis elegans)

pon3.1 [extracellular region] (Danio rerio)

mec-6 [extracellular region] (Caenorhabditis elegans)

poml-1 [extracellular region] (Caenorhabditis elegans)

poml-4 [extracellular region] (Caenorhabditis elegans)

pon2 [extracellular region] (Danio rerio)

pon2 [extracellular region] (Xenopus tropicalis)

poml-2 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001018171.1, NP_000296.2

Guide to Pharmacology - Targets

3053

ENSEMBL

ENSP00000222572, ENST00000222572, ENST00000433091, ENST00000633531, ENSP00000488838, ENSP00000404622, ENSG00000105854

OpenTargets

ENSG00000105854

GeneCards

PON2

HPA

ENSG00000105854-PON2

PRO

Q15165

Pharos - Targets

Q15165

GlyGen

Q15165

Orphanet

PON2

HMDB Protein

HMDBP00092

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15118 NPC1	1	NPC1 [lysosomal membrane] (R-HSA-5216153)	0.527	2
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.527	2
UniProt:Q12891 HYAL2	1	HYAL2 [plasma membrane] (R-HSA-2160919)	0.499	2
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	2

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