Reactome | EAF1 [nucleoplasm]

EAF1 [nucleoplasm]

Stable Identifier

R-HSA-8932787

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ELL-associated factor 1, EAF1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8N3E9 PLCD3

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External Reference Information

External Reference

UniProt:Q96JC9 EAF1

Gene Names

EAF1

Chain

chain:1-268

Reference Genes

BioGPS Gene:85403 EAF1

COSMIC (genes):EAF1 EAF1

CTD Gene:85403 EAF1

dbSNP Gene:85403 EAF1

ENSEMBL:ENSG00000144597 EAF1

ENSEMBL_homo_sapiens_GENE:ENSG00000144597.14 EAF1

HGNC:20907 EAF1

KEGG Gene (Homo sapiens):85403 EAF1

Monarch:85403 EAF1

NCBI Gene:85403 EAF1

OMIM:608315 EAF1

UCSC:Q96JC9 EAF1

Reference Transcript

Other Identifiers

11724306_at

11748059_a_at

11758126_s_at

16938102

226952_PM_at

226952_at

2612373

2612374

2612375

2612376

2612378

2612381

2612383

2612384

2612385

2612386

2612387

53670_at

75439_at

8078138

85403

A_23_P166742

A_24_P174461

A_24_P941930

GE63368

GE83603

GO:0003711

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0006368

GO:0008023

GO:0015030

GO:0016604

GO:0016607

GO:0032783

GO:0034243

GO:0043226

GO:0043231

GO:0045171

GO:0140110

HMNXSV003025903

Hs.63131.0.A1_3p_at

ILMN_1685012

PH_hs_0026451

TC03000096.hg

Participates

as an output of

Elongating transcript encounters a lesion in the template (Homo sapiens)

as a component of

as an input of

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)

Inferred To

EAF1 [nucleoplasm] (Bos taurus)

EAF1 [nucleoplasm] (Canis familiaris)

EAF1 [nucleoplasm] (Gallus gallus)

EAF1 [nucleoplasm] (Sus scrofa)

eaf1 [nucleoplasm] (Schizosaccharomyces pombe)

eaf1 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of EAF1 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of EAF1 [nucleoplasm] (Saccharomyces cerevisiae)

eaf-1 [nucleoplasm] (Caenorhabditis elegans)

Eaf1 [nucleoplasm] (Mus musculus)

Eaf1 [nucleoplasm] (Rattus norvegicus)

Eaf [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_005265575.1, XP_011532467.1, NP_149074.3, XP_011532468.1

OpenTargets

ENSG00000144597

GeneCards

Q96JC9

HPA

ENSG00000144597-EAF1

Ensembl

ENSP00000380054, ENST00000396842, ENSG00000144597

PRO

Q96JC9

Pharos - Targets

Q96JC9

PDB

7OKY, 7OKX

Interactors (69)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.841	9
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.8	9
UniProt:Q9HB65 ELL3	1	ELL3 [nucleoplasm] (R-HSA-6807497)	0.8	8
UniProt:Q9NSC5 HOMER3	1	HOMER3 [cytosol] (R-HSA-6794236)	0.781	7
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.675	4
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.643	6
UniProt:P55199 ELL	1	ELL [nucleoplasm] (R-HSA-54257)	0.643	5
UniProt:P42568 MLLT3	1	MLLT3 [nucleoplasm] (R-HSA-8932789)	0.643	5
UniProt:P51825 AFF1			0.643	5
UniProt:Q9Y2F5 ICE1	1	ICE1 [nucleoplasm] (R-HSA-6807433)	0.643	6
UniProt:Q659A1 ICE2	1	ICE2 [nucleoplasm] (R-HSA-6807421)	0.643	6
UniProt:Q8NCX0-3 CCDC150			0.556	3
UniProt:Q96MF2 STAC3			0.556	5
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.556	3
UniProt:Q5SQQ9-2 VAX1			0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:P19237 TNNI1	1	TNNI1 [cytosol] (R-HSA-390539)	0.556	3
UniProt:Q9NWS0 PIHD1			0.556	3
UniProt:P37108 SRP14	4	SRP14 [cytosol] (R-HSA-264941) SRP14 [secretory granule lumen] (R-HSA-6800938) SRP14 [extracellular region] (R-HSA-6806495) SRP14 [ficolin-1-rich granule lumen] (R-HSA-6800439)	0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q6PI77 GASP3			0.556	3
UniProt:Q12800 TFCP2			0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.556	5
UniProt:P32780 GTF2H1	1	GTF2H1 [nucleoplasm] (R-HSA-65912)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:P52747 ZNF143	1	ZNF143 [nucleoplasm] (R-HSA-83837)	0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:O95379 TNFAIP8	1	TNFAIP8 [cytosol] (R-HSA-8874463)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.556	3
UniProt:Q8N7W2-2 BEND7			0.556	3
UniProt:Q86T90 K1328			0.556	3
UniProt:O75031 HSF2B			0.556	3
IntAct:EBI-23645769 CCSB ORF ID			0.556	3
UniProt:Q5JQS6 GSAML			0.556	3
UniProt:Q4LE39-3 ARID4B			0.556	3
UniProt:O95125 ZNF202	1	ZNF202 [nucleoplasm] (R-HSA-975010)	0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:Q86W67 F228A			0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:Q8TE85-2 GRHL3			0.556	3
UniProt:Q8N8X9 MB213			0.556	3
UniProt:Q8IY57-5 YAF2			0.556	5
UniProt:Q9H147 TDIF1			0.556	3
UniProt:P04279-2 SEMG1			0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q9BVG3 TRIM62	1	TRIM62 [cytosol] (R-HSA-5624340)	0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:Q92759 GTF2H4	1	GTF2H4 [nucleoplasm] (R-HSA-65918)	0.556	3
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.556	3
UniProt:O75052 CAPON			0.527	2
UniProt:Q8TBX8 PIP4K2C	2	PIP4K2C [nucleoplasm] (R-HSA-6811499) PIP4K2C [cytosol] (R-HSA-1604638)	0.527	3
UniProt:Q5VWQ0 RSBN1			0.527	3
UniProt:Q9Y6J0 CABIN1	1	CABIN1 [nucleoplasm] (R-HSA-3878125)	0.527	3
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.527	2
UniProt:Q8N9U0 TAC2N			0.527	3
UniProt:P78356 PIP4K2B	3	p-S326-PIP4K2B [nucleoplasm] (R-HSA-8877679) PIP4K2B [nucleoplasm] (R-HSA-6811503) PIP4K2B [cytosol] (R-HSA-1806208)	0.527	3
UniProt:Q8N3E9 PLCD3	1	PLCD3 [plasma membrane] (R-HSA-2023882)	0.527	3
UniProt:Q03111 MLLT1	1	MLLT1 [nucleoplasm] (R-HSA-8932918)	0.527	4
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	3
UniProt:Q96CJ1 EAF2	1	EAF2 [nucleoplasm] (R-HSA-8932790)	0.527	2
UniProt:P48426 PIP4K2A	2	PIP4K2A [nucleoplasm] (R-HSA-6811484) PIP4K2A [cytosol] (R-HSA-1604641)	0.527	2
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.499	5

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