Reactome | AFF4 [nucleoplasm]

AFF4 [nucleoplasm]

Stable Identifier

R-HSA-8932788

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

AF4/FMR2 family member 4, AFF4_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P21741 MDK

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External Reference Information

External Reference

UniProt:Q9UHB7 AFF4

Gene Names

AFF4, AF5Q31, MCEF, HSPC092

Chain

chain:1-1163

Reference Genes

BioGPS Gene:27125 AFF4

COSMIC (genes):AFF4 AFF4

CTD Gene:27125 AFF4

dbSNP Gene:27125 AFF4

ENSEMBL:ENSG00000072364 AFF4

HGNC:17869 AFF4

KEGG:hsa:27125 AFF4

Monarch:27125 AFF4

NCBI Gene:27125 AFF4

OMIM:604417 AFF4

UCSC:Q9UHB7 AFF4

Reference Transcript

Participates

as an output of

Elongating transcript encounters a lesion in the template (Homo sapiens)

as a component of

as an input of

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)

Inferred To

AFF4 [nucleoplasm] (Bos taurus)

AFF4 [nucleoplasm] (Canis familiaris)

AFF4 [nucleoplasm] (Gallus gallus)

AFF4 [nucleoplasm] (Sus scrofa)

lilli [nucleoplasm] (Drosophila melanogaster)

Aff4 [nucleoplasm] (Mus musculus)

Aff4 [nucleoplasm] (Rattus norvegicus)

aff4 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of AFF4 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of AFF4 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of AFF4 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of AFF4 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_055238.1, XP_005272020.1, XP_054208359.1

OpenTargets

ENSG00000072364

ENSEMBL

ENSG00000072364, ENSP00000367858, ENSP00000265343, ENST00000378595, ENST00000265343

HPA

ENSG00000072364-AFF4

GeneCards

AFF4

PRO

Q9UHB7

Pharos - Targets

Q9UHB7

GlyGen

Q9UHB7

Orphanet

AFF4

PDB

6R80, 4IMY, 5L1Z, 4OR5, 5JW9, 6KN5, 4OGR, 6CYT, 6K7P

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.903	13
UniProt:O60563 CCNT1	1	CCNT1 [nucleoplasm] (R-HSA-51611)	0.81	8
UniProt:Q03111 MLLT1	1	MLLT1 [nucleoplasm] (R-HSA-8932918)	0.758	11
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.725	6
UniProt:Q96CJ1 EAF2	1	EAF2 [nucleoplasm] (R-HSA-8932790)	0.643	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.643	6
UniProt:P55199 ELL	1	ELL [nucleoplasm] (R-HSA-54257)	0.643	4
UniProt:P48426 PIP4K2A	2	PIP4K2A [cytosol] (R-HSA-1604641) PIP4K2A [nucleoplasm] (R-HSA-6811484)	0.643	3
UniProt:Q9HB65 ELL3	1	ELL3 [nucleoplasm] (R-HSA-6807497)	0.643	4
UniProt:P51825 AFF1			0.597	8
UniProt:P42568 MLLT3	1	MLLT3 [nucleoplasm] (R-HSA-8932789)	0.564	4
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.558	4
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.556	5
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P63010 AP2B1	4	AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [cytosol] (R-HSA-182166) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [endolysosome membrane] (R-HSA-6784827)	0.556	3
UniProt:P21741 MDK	1	MDK [extracellular region] (R-HSA-2160953)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	4
UniProt:O60583 CCNT2	1	CCNT2 [nucleoplasm] (R-HSA-51613)	0.527	3
UniProt:Q8IZU1 FAM9A			0.527	2
UniProt:O00541 PES1	1	PES1 [nucleoplasm] (R-HSA-6791207)	0.527	2
UniProt:Q8NCB2 CAMKV			0.527	2
UniProt:Q5VWQ0 RSBN1			0.527	2
UniProt:P40425 PBX2			0.527	2
UniProt:Q9H6A0 DENND2D	1	DENND2D [cytosol] (R-HSA-8876071)	0.527	2
UniProt:Q9H4G0 EPB41L1	2	EPB41L1 [cytosol] (R-HSA-392241) EPB41L1 [plasma membrane] (R-HSA-416333)	0.527	2
UniProt:O94992 HEXI1			0.527	2

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