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MLLT3 [nucleoplasm]
Stable Identifier
R-HSA-8932789
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Protein AF-9, AF9_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
MLLT3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42568 MLLT3
Gene Names
MLLT3, AF9, YEATS3
Chain
chain:1-568
Reference Genes
BioGPS Gene:4300 MLLT3
COSMIC (genes):MLLT3 MLLT3
CTD Gene:4300 MLLT3
dbSNP Gene:4300 MLLT3
ENSEMBL:ENSG00000171843 MLLT3
HGNC:7136 MLLT3
KEGG:hsa:4300 MLLT3
Monarch:4300 MLLT3
NCBI Gene:4300 MLLT3
OMIM:159558 MLLT3
UCSC:P42568 MLLT3
Reference Transcript
RefSeq:NM_004529.3 MLLT3
RefSeq:NM_001286691.1 MLLT3
Other Identifiers
11747870_a_at
11754396_a_at
1569652_PM_at
1569652_at
17092767
204917_PM_s_at
204917_s_at
204918_PM_s_at
204918_s_at
3200979
3200981
3200983
3200984
3200985
3200986
3200987
3200988
3200990
3200992
3200993
3200994
3200996
3200999
3201001
3201011
3201012
3201018
3201022
3201061
3201064
3201065
3201066
3201069
35975_at
4300
8160332
A_23_P216693
A_24_P192627
D16688_s_at
GE81406
GE902483
GO:0003677
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006355
GO:0007379
GO:0008023
GO:0009952
GO:0010467
GO:0030154
GO:0042393
GO:0043226
GO:0043229
GO:0045893
GO:0060090
GO:0060218
GO:0070062
GO:0070577
GO:0090090
GO:0140030
GO:1902275
GO:2000035
GO:2000096
HMNXSV003008935
Hs.404.0.S1_3p_a_at
Hs2.382134.1.S1_3p_at
ILMN_1812473
L13744_at
PH_hs_0000048
PH_hs_0015976
TC09000941.hg
g4758719_3p_a_at
Participates
as an output of
Elongating transcript encounters a lesion in the template (Homo sapiens)
as a component of
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Homo sapiens)
as an input of
Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)
Inferred To
Mllt3 [nucleoplasm]
(Mus musculus)
Mllt3 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of MLLT3 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of MLLT3 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of MLLT3 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of MLLT3 [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of MLLT3 [nucleoplasm]
(Schizosaccharomyces pombe)
MLLT3 [nucleoplasm]
(Bos taurus)
MLLT3 [nucleoplasm]
(Canis familiaris)
MLLT3 [nucleoplasm]
(Gallus gallus)
MLLT3 [nucleoplasm]
(Sus scrofa)
mllt3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000171843
ENSEMBL
ENST00000630269
,
ENSP00000369695
,
ENSG00000171843
,
ENSP00000485996
,
ENST00000380338
HPA
ENSG00000171843-MLLT3
GeneCards
MLLT3
PRO
P42568
Pharos - Targets
P42568
Orphanet
MLLT3
GlyGen
P42568
PDB
2N4Q
,
7VKH
,
2NDF
,
2LM0
,
2MV7
,
2NDG
,
5HJD
,
6MIL
,
6MIM
,
6B7G
,
6L5Z
,
8PJ7
,
8TLW
,
7VKG
,
8TLV
,
7EIC
,
5HJB
,
7EID
,
6LS6
,
8TLX
,
5YYF
,
4TMP
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8TEK3 DOT1L
1
DOT1L [nucleoplasm]
(R-HSA-3239030)
0.821
7
UniProt:Q8IZU1 FAM9A
0.742
5
UniProt:P51825 AFF1
0.734
7
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.725
6
UniProt:Q9NXW9 ALKB4
0.682
5
UniProt:Q5JXC2 MIIP
0.666
4
UniProt:Q92624 APBP2
0.666
4
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.643
5
UniProt:Q03111 MLLT1
1
MLLT1 [nucleoplasm]
(R-HSA-8932918)
0.643
4
UniProt:P55198 AF17
0.643
3
UniProt:Q9HB65 ELL3
1
ELL3 [nucleoplasm]
(R-HSA-6807497)
0.643
3
UniProt:Q9UHB7 AFF4
1
AFF4 [nucleoplasm]
(R-HSA-8932788)
0.564
4
UniProt:Q7Z3I7 ZN572
0.556
3
UniProt:Q5SQQ9-2 VAX1
0.556
3
UniProt:Q9HC52 CBX8
1
CBX8 [nucleoplasm]
(R-HSA-389117)
0.544
2
UniProt:Q6W2J9-1 BCOR
0.544
2
UniProt:P21741 MDK
1
MDK [extracellular region]
(R-HSA-2160953)
0.527
2
UniProt:Q9NQT5 EXOSC3
3
EXOSC3 [nucleolus]
(R-HSA-9935842)
EXOSC3 [nucleoplasm]
(R-HSA-6791572)
EXOSC3 [cytosol]
(R-HSA-430017)
0.527
2
UniProt:P48426 PIP4K2A
2
PIP4K2A [cytosol]
(R-HSA-1604641)
PIP4K2A [nucleoplasm]
(R-HSA-6811484)
0.527
2
UniProt:Q9Y2J2 EPB41L3
1
EPB41L3 [cytosol]
(R-HSA-6797563)
0.527
2
UniProt:Q8TDL5 BPIFB1
1
BPIFB1 [extracellular region]
(R-HSA-6809282)
0.527
2
UniProt:O00541 PES1
1
PES1 [nucleoplasm]
(R-HSA-6791207)
0.527
2
UniProt:Q9H6A0 DENND2D
1
DENND2D [cytosol]
(R-HSA-8876071)
0.527
2
UniProt:O43491 EPB41L2
1
EPB41L2 [cytosol]
(R-HSA-6797548)
0.527
2
UniProt:O00472 ELL2
1
ELL2 [nucleoplasm]
(R-HSA-6807506)
0.527
3
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