Reactome | MLLT1 [nucleoplasm]

MLLT1 [nucleoplasm]

Stable Identifier

R-HSA-8932918

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein ENL, ENL_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q03111 MLLT1

Gene Names

MLLT1, ENL, LTG19, YEATS1

Chain

chain:1-559

Reference Genes

BioGPS Gene:4298 MLLT1

COSMIC (genes):MLLT1 MLLT1

CTD Gene:4298 MLLT1

dbSNP Gene:4298 MLLT1

ENSEMBL:ENSG00000130382 MLLT1

HGNC:7134 MLLT1

KEGG:hsa:4298 MLLT1

Monarch:4298 MLLT1

NCBI Gene:4298 MLLT1

OMIM:159556 MLLT1

UCSC:Q03111 MLLT1

Reference Transcript

RefSeq:NM_005934.3 MLLT1

Other Identifiers

11725398_at

11725399_s_at

11763620_a_at

11763626_a_at

16867635

214477_PM_at

214477_at

224993_PM_at

224993_at

32400_at

3847704

3847705

3847706

3847707

3847708

3847709

3847710

3847711

3847712

3847713

3847714

3847715

3847716

3847718

3847719

3847720

3847721

3847724

3847725

3847726

3847727

3847732

3847735

3847747

3847750

3847753

4298

55750_at

58879_at

8033118

A_23_P153827

A_24_P151295

A_24_P418126

A_33_P3282394

A_33_P3289541

GE63359

GE722971

GO:0001650

GO:0003682

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006355

GO:0008023

GO:0042393

GO:0043226

GO:0043229

GO:0045893

GO:0070577

HMNXSV003021201

Hs.10095.0.S1_3p_at

Hs.10095.0.S1_3p_x_at

Hs.234774.0.S1_3p_at

Hs.234774.0.S1_3p_x_at

ILMN_1706590

PH_hs_0001041

PH_hs_0030983

TC19001091.hg

Participates

as an output of

Elongating transcript encounters a lesion in the template (Homo sapiens)

as a component of

as an input of

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Homo sapiens)

Inferred To

MLLT1 [nucleoplasm] (Bos taurus)

MLLT1 [nucleoplasm] (Canis familiaris)

MLLT1 [nucleoplasm] (Gallus gallus)

MLLT1 [nucleoplasm] (Sus scrofa)

mllt1 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of MLLT1 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of MLLT1 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of MLLT1 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of MLLT1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of MLLT1 [nucleoplasm] (Schizosaccharomyces pombe)

Mllt1 [nucleoplasm] (Mus musculus)

Mllt1 [nucleoplasm] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

3183

OpenTargets

ENSG00000130382

ENSEMBL

ENST00000252674, ENSP00000252674

HPA

ENSG00000130382-MLLT1

PRO

Q03111

Pharos - Targets

Q03111

GlyGen

Q03111

PDB

7E74, 6T1L, 7X88, 6HPW, 7E7A, 6HQ0, 7X8G, 7B10, 7X8B, 6HPY, 7E7C, 6HPX, 7X8F, 6T1N, 5J9S, 6T1M, 6HT0, 6HPZ, 6T1I, 6T1J, 6HT1, 8PJI, 6T1O, 7B0T

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.788	7
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.758	11
UniProt:Q8TEK3 DOT1L	1	DOT1L [nucleoplasm] (R-HSA-3239030)	0.677	8
UniProt:P42568 MLLT3	1	MLLT3 [nucleoplasm] (R-HSA-8932789)	0.643	4
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.643	4
UniProt:P51825 AFF1			0.597	9
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:O60563 CCNT1	1	CCNT1 [nucleoplasm] (R-HSA-51611)	0.527	3
UniProt:Q9H6A0 DENND2D	1	DENND2D [cytosol] (R-HSA-8876071)	0.527	2
UniProt:Q8IY57 YAF2	1	YAF2 [nucleoplasm] (R-HSA-8937973)	0.527	3
UniProt:O43491 EPB41L2	1	EPB41L2 [cytosol] (R-HSA-6797548)	0.527	2
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.527	2
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.527	4
UniProt:P48426 PIP4K2A	2	PIP4K2A [cytosol] (R-HSA-1604641) PIP4K2A [nucleoplasm] (R-HSA-6811484)	0.527	2
UniProt:Q9BSM1 PCGF1			0.527	2
UniProt:Q9HB65 ELL3	1	ELL3 [nucleoplasm] (R-HSA-6807497)	0.527	4
UniProt:Q8TDL5 BPIFB1	1	BPIFB1 [extracellular region] (R-HSA-6809282)	0.527	2
UniProt:Q6W2J9 BCOR			0.527	3
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.462	2

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