SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane

Stable Identifier
R-HSA-8932980
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane
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Serine incorporators 1-5 (SERINC1-5) are membrane-associated proteins that incorporate the polar amino acid serine (L-Ser) into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipids. SERINC3 and 5 have recently been identified to be restrictors to HIV replication in human cells (Fackler 2015, Usami et al. 2015).
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Catalyst Activity

L-serine transmembrane transporter activity of SERINC3,5,(1,2,4) [plasma membrane]

Physical Entity
SERINC3,5,(1,2,4) [plasma membrane] (Homo sapiens)
Activity
L-serine transmembrane transporter activity (GO:0015194)
Orthologous Events
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Bos taurus)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Caenorhabditis elegans)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Canis familiaris)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Danio rerio)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Dictyostelium discoideum)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Drosophila melanogaster)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Gallus gallus)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Mus musculus)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Rattus norvegicus)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Saccharomyces cerevisiae)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Schizosaccharomyces pombe)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Sus scrofa)
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2016-08-01)
Reviewed
D'Eustachio, P  (2016-08-12)
Created
Jassal, B  (2016-08-01)
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