Reactome | SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane

SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane

Stable Identifier

R-HSA-8932980

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane

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Serine incorporators 1-5 (SERINC1-5) are membrane-associated proteins that incorporate the polar amino acid serine (L-Ser) into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipids (nuzuka et al. 2005). SERINC3 and 5 have recently been identified to be restrictors to HIV replication in human cells (Fackler 2015, Usami et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26416733	SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef Usami, Y, Wu, Y, Göttlinger, HG	Nature	2015
26703715	Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor Fackler, OT	Viruses	2015
16120614	Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis Inuzuka, M, Hayakawa, M, Ingi, T	J Biol Chem	2005