Reactome | RUNX1 binds SIN3A,(SIN3B) co-repressor

RUNX1 binds SIN3A,(SIN3B) co-repressor

Stable Identifier

R-HSA-8935732

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The RUNX1:CBFB complex can bind to transcriptional co-repressors SIN3A and SIN3B. The interaction with SIN3A has been studied in more detail. Binding to SIN3A leads to transcriptional repression of RUNX1 target genes, which may involve SIN3A-mediated recruitment of histone deacetylases (HDACs) to target promoters (Lutterbach et al. 2000). Arginine methylation of RUNX1 by PRMT1 inhibits association of RUNX1 with SIN3A (Zhao et al. 2008). RUNX1 transcriptional repressor complex with SIN3A also includes histone arginine methyltransferase PRMT6 and HDAC1 (Herglotz et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
10617663	A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia Lutterbach, B, Westendorf, JJ, Linggi, B, Isaac, S, Seto, E, Hiebert, SW	J. Biol. Chem.	2000
18316480	Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity Zhao, X, Jankovic, V, Gural, A, Huang, G, Pardanani, A, Menendez, S, Zhang, J, Dunne, R, Xiao, A, Erdjument-Bromage, H, Allis, CD, Tempst, P, Nimer, SD	Genes Dev.	2008
22777353	Histone arginine methylation keeps RUNX1 target genes in an intermediate state Herglotz, J, Kuvardina, ON, Kolodziej, S, Kumar, A, Hussong, H, Grez, M, Lausen, J	Oncogene	2013